Universal toxin-based selection for precise genome engineering in human cells

Universal toxin-based selection for precise genome engineering in human cells

Genome engineering in cell lines or human stem cells often has poor efficiency, limiting the development of research and therapeutic applications. Here, the authors use a toxin-based selection system for precise bi-allelic engineering in cells and in vivo.

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Detalles Bibliográficos
Autores principales: Songyuan Li, Nina Akrap, Silvia Cerboni, Michelle J. Porritt, Sandra Wimberger, Anders Lundin, Carl Möller, Mike Firth, Euan Gordon, Bojana Lazovic, Aleksandra Sieńska, Luna Simona Pane, Matthew A. Coelho, Giovanni Ciotta, Giovanni Pellegrini, Marcella Sini, Xiufeng Xu, Suman Mitra, Mohammad Bohlooly-Y, Benjamin J. M. Taylor, Grzegorz Sienski, Marcello Maresca
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
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Acceso en línea:https://doaj.org/article/5902061ff2c8407598c33e5d4d157a46
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Descripción
Sumario:Genome engineering in cell lines or human stem cells often has poor efficiency, limiting the development of research and therapeutic applications. Here, the authors use a toxin-based selection system for precise bi-allelic engineering in cells and in vivo.

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