Universal toxin-based selection for precise genome engineering in human cells
Genome engineering in cell lines or human stem cells often has poor efficiency, limiting the development of research and therapeutic applications. Here, the authors use a toxin-based selection system for precise bi-allelic engineering in cells and in vivo.
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Nature Portfolio
2021
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oai:doaj.org-article:5902061ff2c8407598c33e5d4d157a462021-12-02T13:57:11ZUniversal toxin-based selection for precise genome engineering in human cells10.1038/s41467-020-20810-z2041-1723https://doaj.org/article/5902061ff2c8407598c33e5d4d157a462021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20810-zhttps://doaj.org/toc/2041-1723Genome engineering in cell lines or human stem cells often has poor efficiency, limiting the development of research and therapeutic applications. Here, the authors use a toxin-based selection system for precise bi-allelic engineering in cells and in vivo.Songyuan LiNina AkrapSilvia CerboniMichelle J. PorrittSandra WimbergerAnders LundinCarl MöllerMike FirthEuan GordonBojana LazovicAleksandra SieńskaLuna Simona PaneMatthew A. CoelhoGiovanni CiottaGiovanni PellegriniMarcella SiniXiufeng XuSuman MitraMohammad Bohlooly-YBenjamin J. M. TaylorGrzegorz SienskiMarcello MarescaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Songyuan Li Nina Akrap Silvia Cerboni Michelle J. Porritt Sandra Wimberger Anders Lundin Carl Möller Mike Firth Euan Gordon Bojana Lazovic Aleksandra Sieńska Luna Simona Pane Matthew A. Coelho Giovanni Ciotta Giovanni Pellegrini Marcella Sini Xiufeng Xu Suman Mitra Mohammad Bohlooly-Y Benjamin J. M. Taylor Grzegorz Sienski Marcello Maresca Universal toxin-based selection for precise genome engineering in human cells |
| description |
Genome engineering in cell lines or human stem cells often has poor efficiency, limiting the development of research and therapeutic applications. Here, the authors use a toxin-based selection system for precise bi-allelic engineering in cells and in vivo. |
| format |
article |
| author |
Songyuan Li Nina Akrap Silvia Cerboni Michelle J. Porritt Sandra Wimberger Anders Lundin Carl Möller Mike Firth Euan Gordon Bojana Lazovic Aleksandra Sieńska Luna Simona Pane Matthew A. Coelho Giovanni Ciotta Giovanni Pellegrini Marcella Sini Xiufeng Xu Suman Mitra Mohammad Bohlooly-Y Benjamin J. M. Taylor Grzegorz Sienski Marcello Maresca |
| author_facet |
Songyuan Li Nina Akrap Silvia Cerboni Michelle J. Porritt Sandra Wimberger Anders Lundin Carl Möller Mike Firth Euan Gordon Bojana Lazovic Aleksandra Sieńska Luna Simona Pane Matthew A. Coelho Giovanni Ciotta Giovanni Pellegrini Marcella Sini Xiufeng Xu Suman Mitra Mohammad Bohlooly-Y Benjamin J. M. Taylor Grzegorz Sienski Marcello Maresca |
| author_sort |
Songyuan Li |
| title |
Universal toxin-based selection for precise genome engineering in human cells |
| title_short |
Universal toxin-based selection for precise genome engineering in human cells |
| title_full |
Universal toxin-based selection for precise genome engineering in human cells |
| title_fullStr |
Universal toxin-based selection for precise genome engineering in human cells |
| title_full_unstemmed |
Universal toxin-based selection for precise genome engineering in human cells |
| title_sort |
universal toxin-based selection for precise genome engineering in human cells |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/5902061ff2c8407598c33e5d4d157a46 |
| work_keys_str_mv |
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| _version_ |
1718392323073638400 |