Haematopoietic ESL-1 enables stem cell proliferation in the bone marrow by limiting TGFβ availability

Hematopoietic stem and progenitor cell (HSPCs) proliferation is controlled by signals from the niche. Here, Leivaet al. show in vivoin mice that deletion of E-selectin ligand 1 causes quiescence of HSPCs and a reduction in niche size, which is mediated by changes of TGFß levels in the bone marrow.

Guardado en:

Detalles Bibliográficos
Autores principales:	Magdalena Leiva, Juan A. Quintana, José M. Ligos, Andrés Hidalgo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/590357cb8e5242c5a6fe807145cf27d3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:590357cb8e5242c5a6fe807145cf27d3
record_format	dspace
spelling	oai:doaj.org-article:590357cb8e5242c5a6fe807145cf27d32021-12-02T15:35:45ZHaematopoietic ESL-1 enables stem cell proliferation in the bone marrow by limiting TGFβ availability10.1038/ncomms102222041-1723https://doaj.org/article/590357cb8e5242c5a6fe807145cf27d32016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10222https://doaj.org/toc/2041-1723Hematopoietic stem and progenitor cell (HSPCs) proliferation is controlled by signals from the niche. Here, Leivaet al. show in vivoin mice that deletion of E-selectin ligand 1 causes quiescence of HSPCs and a reduction in niche size, which is mediated by changes of TGFß levels in the bone marrow.Magdalena LeivaJuan A. QuintanaJosé M. LigosAndrés HidalgoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Magdalena Leiva Juan A. Quintana José M. Ligos Andrés Hidalgo Haematopoietic ESL-1 enables stem cell proliferation in the bone marrow by limiting TGFβ availability
description	Hematopoietic stem and progenitor cell (HSPCs) proliferation is controlled by signals from the niche. Here, Leivaet al. show in vivoin mice that deletion of E-selectin ligand 1 causes quiescence of HSPCs and a reduction in niche size, which is mediated by changes of TGFß levels in the bone marrow.
format	article
author	Magdalena Leiva Juan A. Quintana José M. Ligos Andrés Hidalgo
author_facet	Magdalena Leiva Juan A. Quintana José M. Ligos Andrés Hidalgo
author_sort	Magdalena Leiva
title	Haematopoietic ESL-1 enables stem cell proliferation in the bone marrow by limiting TGFβ availability
title_short	Haematopoietic ESL-1 enables stem cell proliferation in the bone marrow by limiting TGFβ availability
title_full	Haematopoietic ESL-1 enables stem cell proliferation in the bone marrow by limiting TGFβ availability
title_fullStr	Haematopoietic ESL-1 enables stem cell proliferation in the bone marrow by limiting TGFβ availability
title_full_unstemmed	Haematopoietic ESL-1 enables stem cell proliferation in the bone marrow by limiting TGFβ availability
title_sort	haematopoietic esl-1 enables stem cell proliferation in the bone marrow by limiting tgfβ availability
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/590357cb8e5242c5a6fe807145cf27d3
work_keys_str_mv	AT magdalenaleiva haematopoieticesl1enablesstemcellproliferationinthebonemarrowbylimitingtgfbavailability AT juanaquintana haematopoieticesl1enablesstemcellproliferationinthebonemarrowbylimitingtgfbavailability AT josemligos haematopoieticesl1enablesstemcellproliferationinthebonemarrowbylimitingtgfbavailability AT andreshidalgo haematopoieticesl1enablesstemcellproliferationinthebonemarrowbylimitingtgfbavailability
_version_	1718386474310696960

Haematopoietic ESL-1 enables stem cell proliferation in the bone marrow by limiting TGFβ availability

Ejemplares similares