Impact of coexisting coronary artery disease on the occurrence of cerebral ischemic lesions after carotid stenting.

<h4>Background</h4>Coronary artery disease (CAD) may coexist with extracranial carotid artery stenosis (ECAS), but the influence of CAD on procedure-related complications after carotid artery stenting (CAS) has not been well investigated. The study aimed to determine the impact of CAD on...

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Autores principales: Kuo-Lun Huang, Yeu-Jhy Chang, Chien-Hung Chang, Ting-Yu Chang, Chi-Hung Liu, I-Chang Hsieh, Ho-Fai Wong, Yau-Yau Wai, Yu-Wei Chen, Bak-Sau Yip, Tsong-Hai Lee
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Publicado: Public Library of Science (PLoS) 2014
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spelling oai:doaj.org-article:590ba8bb88df4ec0804f1ab5b7e726b62021-11-18T08:23:32ZImpact of coexisting coronary artery disease on the occurrence of cerebral ischemic lesions after carotid stenting.1932-620310.1371/journal.pone.0094280https://doaj.org/article/590ba8bb88df4ec0804f1ab5b7e726b62014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24732408/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Coronary artery disease (CAD) may coexist with extracranial carotid artery stenosis (ECAS), but the influence of CAD on procedure-related complications after carotid artery stenting (CAS) has not been well investigated. The study aimed to determine the impact of CAD on the occurrence of peri-CAS cerebral ischemic lesions on diffusion-weighted imaging (DWI) scanning.<h4>Methods</h4>Coronary angiography was performed within six months before CAS. DWI scanning was repetitively done within 1 week before and after CAS. Clinical outcome measures were stroke, angina, myocardial infarction and death within 30 days.<h4>Results</h4>Among 126 patients (69.5±9.0 years) recruited for unilateral protected CAS, 33 (26%) patients had peri-CAS DWI-positive lesions. CAD was noted in 79% (26 in 33) and 48% (45 in 93) of patients with and without peri-CAS DWI-positive lesions (OR, 4.0; 95% CI, 1.6-10.0; P = .0018), and the number of concomitant CAD on coronary angiography was positively correlated with the risk for peri-CAS DWI-positive lesions (P = .0032). In patients with no CAD (n = 55), asymptomatic CAD (n = 41) and symptomatic CAD (n = 30), the occurrence rates of peri-CAS DWI-positive lesions were 13%, 41% and 30% (P = .0048), and the peri-CAS stroke rates were 2%, 7% and 0% (P = .2120).<h4>Conclusions</h4>The severity of morphological CAD and the presence of either symptomatic or asymptomatic CAD are associated with the occurrence of peri-CAS cerebral ischemic lesions.Kuo-Lun HuangYeu-Jhy ChangChien-Hung ChangTing-Yu ChangChi-Hung LiuI-Chang HsiehHo-Fai WongYau-Yau WaiYu-Wei ChenBak-Sau YipTsong-Hai LeePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 4, p e94280 (2014)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Kuo-Lun Huang
Yeu-Jhy Chang
Chien-Hung Chang
Ting-Yu Chang
Chi-Hung Liu
I-Chang Hsieh
Ho-Fai Wong
Yau-Yau Wai
Yu-Wei Chen
Bak-Sau Yip
Tsong-Hai Lee
Impact of coexisting coronary artery disease on the occurrence of cerebral ischemic lesions after carotid stenting.
description <h4>Background</h4>Coronary artery disease (CAD) may coexist with extracranial carotid artery stenosis (ECAS), but the influence of CAD on procedure-related complications after carotid artery stenting (CAS) has not been well investigated. The study aimed to determine the impact of CAD on the occurrence of peri-CAS cerebral ischemic lesions on diffusion-weighted imaging (DWI) scanning.<h4>Methods</h4>Coronary angiography was performed within six months before CAS. DWI scanning was repetitively done within 1 week before and after CAS. Clinical outcome measures were stroke, angina, myocardial infarction and death within 30 days.<h4>Results</h4>Among 126 patients (69.5±9.0 years) recruited for unilateral protected CAS, 33 (26%) patients had peri-CAS DWI-positive lesions. CAD was noted in 79% (26 in 33) and 48% (45 in 93) of patients with and without peri-CAS DWI-positive lesions (OR, 4.0; 95% CI, 1.6-10.0; P = .0018), and the number of concomitant CAD on coronary angiography was positively correlated with the risk for peri-CAS DWI-positive lesions (P = .0032). In patients with no CAD (n = 55), asymptomatic CAD (n = 41) and symptomatic CAD (n = 30), the occurrence rates of peri-CAS DWI-positive lesions were 13%, 41% and 30% (P = .0048), and the peri-CAS stroke rates were 2%, 7% and 0% (P = .2120).<h4>Conclusions</h4>The severity of morphological CAD and the presence of either symptomatic or asymptomatic CAD are associated with the occurrence of peri-CAS cerebral ischemic lesions.
format article
author Kuo-Lun Huang
Yeu-Jhy Chang
Chien-Hung Chang
Ting-Yu Chang
Chi-Hung Liu
I-Chang Hsieh
Ho-Fai Wong
Yau-Yau Wai
Yu-Wei Chen
Bak-Sau Yip
Tsong-Hai Lee
author_facet Kuo-Lun Huang
Yeu-Jhy Chang
Chien-Hung Chang
Ting-Yu Chang
Chi-Hung Liu
I-Chang Hsieh
Ho-Fai Wong
Yau-Yau Wai
Yu-Wei Chen
Bak-Sau Yip
Tsong-Hai Lee
author_sort Kuo-Lun Huang
title Impact of coexisting coronary artery disease on the occurrence of cerebral ischemic lesions after carotid stenting.
title_short Impact of coexisting coronary artery disease on the occurrence of cerebral ischemic lesions after carotid stenting.
title_full Impact of coexisting coronary artery disease on the occurrence of cerebral ischemic lesions after carotid stenting.
title_fullStr Impact of coexisting coronary artery disease on the occurrence of cerebral ischemic lesions after carotid stenting.
title_full_unstemmed Impact of coexisting coronary artery disease on the occurrence of cerebral ischemic lesions after carotid stenting.
title_sort impact of coexisting coronary artery disease on the occurrence of cerebral ischemic lesions after carotid stenting.
publisher Public Library of Science (PLoS)
publishDate 2014
url https://doaj.org/article/590ba8bb88df4ec0804f1ab5b7e726b6
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