Impact of coexisting coronary artery disease on the occurrence of cerebral ischemic lesions after carotid stenting.
<h4>Background</h4>Coronary artery disease (CAD) may coexist with extracranial carotid artery stenosis (ECAS), but the influence of CAD on procedure-related complications after carotid artery stenting (CAS) has not been well investigated. The study aimed to determine the impact of CAD on...
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oai:doaj.org-article:590ba8bb88df4ec0804f1ab5b7e726b62021-11-18T08:23:32ZImpact of coexisting coronary artery disease on the occurrence of cerebral ischemic lesions after carotid stenting.1932-620310.1371/journal.pone.0094280https://doaj.org/article/590ba8bb88df4ec0804f1ab5b7e726b62014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24732408/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Coronary artery disease (CAD) may coexist with extracranial carotid artery stenosis (ECAS), but the influence of CAD on procedure-related complications after carotid artery stenting (CAS) has not been well investigated. The study aimed to determine the impact of CAD on the occurrence of peri-CAS cerebral ischemic lesions on diffusion-weighted imaging (DWI) scanning.<h4>Methods</h4>Coronary angiography was performed within six months before CAS. DWI scanning was repetitively done within 1 week before and after CAS. Clinical outcome measures were stroke, angina, myocardial infarction and death within 30 days.<h4>Results</h4>Among 126 patients (69.5±9.0 years) recruited for unilateral protected CAS, 33 (26%) patients had peri-CAS DWI-positive lesions. CAD was noted in 79% (26 in 33) and 48% (45 in 93) of patients with and without peri-CAS DWI-positive lesions (OR, 4.0; 95% CI, 1.6-10.0; P = .0018), and the number of concomitant CAD on coronary angiography was positively correlated with the risk for peri-CAS DWI-positive lesions (P = .0032). In patients with no CAD (n = 55), asymptomatic CAD (n = 41) and symptomatic CAD (n = 30), the occurrence rates of peri-CAS DWI-positive lesions were 13%, 41% and 30% (P = .0048), and the peri-CAS stroke rates were 2%, 7% and 0% (P = .2120).<h4>Conclusions</h4>The severity of morphological CAD and the presence of either symptomatic or asymptomatic CAD are associated with the occurrence of peri-CAS cerebral ischemic lesions.Kuo-Lun HuangYeu-Jhy ChangChien-Hung ChangTing-Yu ChangChi-Hung LiuI-Chang HsiehHo-Fai WongYau-Yau WaiYu-Wei ChenBak-Sau YipTsong-Hai LeePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 4, p e94280 (2014) |
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Medicine R Science Q Kuo-Lun Huang Yeu-Jhy Chang Chien-Hung Chang Ting-Yu Chang Chi-Hung Liu I-Chang Hsieh Ho-Fai Wong Yau-Yau Wai Yu-Wei Chen Bak-Sau Yip Tsong-Hai Lee Impact of coexisting coronary artery disease on the occurrence of cerebral ischemic lesions after carotid stenting. |
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<h4>Background</h4>Coronary artery disease (CAD) may coexist with extracranial carotid artery stenosis (ECAS), but the influence of CAD on procedure-related complications after carotid artery stenting (CAS) has not been well investigated. The study aimed to determine the impact of CAD on the occurrence of peri-CAS cerebral ischemic lesions on diffusion-weighted imaging (DWI) scanning.<h4>Methods</h4>Coronary angiography was performed within six months before CAS. DWI scanning was repetitively done within 1 week before and after CAS. Clinical outcome measures were stroke, angina, myocardial infarction and death within 30 days.<h4>Results</h4>Among 126 patients (69.5±9.0 years) recruited for unilateral protected CAS, 33 (26%) patients had peri-CAS DWI-positive lesions. CAD was noted in 79% (26 in 33) and 48% (45 in 93) of patients with and without peri-CAS DWI-positive lesions (OR, 4.0; 95% CI, 1.6-10.0; P = .0018), and the number of concomitant CAD on coronary angiography was positively correlated with the risk for peri-CAS DWI-positive lesions (P = .0032). In patients with no CAD (n = 55), asymptomatic CAD (n = 41) and symptomatic CAD (n = 30), the occurrence rates of peri-CAS DWI-positive lesions were 13%, 41% and 30% (P = .0048), and the peri-CAS stroke rates were 2%, 7% and 0% (P = .2120).<h4>Conclusions</h4>The severity of morphological CAD and the presence of either symptomatic or asymptomatic CAD are associated with the occurrence of peri-CAS cerebral ischemic lesions. |
format |
article |
author |
Kuo-Lun Huang Yeu-Jhy Chang Chien-Hung Chang Ting-Yu Chang Chi-Hung Liu I-Chang Hsieh Ho-Fai Wong Yau-Yau Wai Yu-Wei Chen Bak-Sau Yip Tsong-Hai Lee |
author_facet |
Kuo-Lun Huang Yeu-Jhy Chang Chien-Hung Chang Ting-Yu Chang Chi-Hung Liu I-Chang Hsieh Ho-Fai Wong Yau-Yau Wai Yu-Wei Chen Bak-Sau Yip Tsong-Hai Lee |
author_sort |
Kuo-Lun Huang |
title |
Impact of coexisting coronary artery disease on the occurrence of cerebral ischemic lesions after carotid stenting. |
title_short |
Impact of coexisting coronary artery disease on the occurrence of cerebral ischemic lesions after carotid stenting. |
title_full |
Impact of coexisting coronary artery disease on the occurrence of cerebral ischemic lesions after carotid stenting. |
title_fullStr |
Impact of coexisting coronary artery disease on the occurrence of cerebral ischemic lesions after carotid stenting. |
title_full_unstemmed |
Impact of coexisting coronary artery disease on the occurrence of cerebral ischemic lesions after carotid stenting. |
title_sort |
impact of coexisting coronary artery disease on the occurrence of cerebral ischemic lesions after carotid stenting. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doaj.org/article/590ba8bb88df4ec0804f1ab5b7e726b6 |
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