In vivo Bio-Distribution and Toxicity Evaluation of Polymeric and Lipid-Based Nanoparticles: A Potential Approach for Chronic Diseases Treatment

João Fonseca-Gomes,1,2,* Joana A Loureiro,3,* Sara R Tanqueiro,1,2 Francisco M Mouro,1,2 Pedro Ruivo,2 Tânia Carvalho,2 Ana M Sebastião,1,2 Maria José Diógenes,1,2,* Maria Carmo Pereira1– 3,* 1Instituto de Farmacologia e Neuroci&eci...

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Autores principales:	Fonseca-Gomes J, Loureiro JA, Tanqueiro SR, Mouro FM, Ruivo P, Carvalho T, Sebastião AM, Diógenes MJ, Pereira MC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	long-lasting treatment drug delivery systems nanocarriers liposomes solid lipid nanoparticles plga nanoparticles Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/590eaacda7904dd69c77e11bec12fd0e
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spelling	oai:doaj.org-article:590eaacda7904dd69c77e11bec12fd0e2021-12-02T12:26:38ZIn vivo Bio-Distribution and Toxicity Evaluation of Polymeric and Lipid-Based Nanoparticles: A Potential Approach for Chronic Diseases Treatment1178-2013https://doaj.org/article/590eaacda7904dd69c77e11bec12fd0e2020-11-01T00:00:00Zhttps://www.dovepress.com/in-vivo-bio-distribution-and-toxicity-evaluation-of-polymeric-and-lipi-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013João Fonseca-Gomes,1,2,* Joana A Loureiro,3,* Sara R Tanqueiro,1,2 Francisco M Mouro,1,2 Pedro Ruivo,2 Tânia Carvalho,2 Ana M Sebastião,1,2 Maria José Diógenes,1,2,* Maria Carmo Pereira1– 3,* 1Instituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, Lisboa 1649-028, Portugal; 2Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa 1649-028, Portugal; 3LEPABE – Laboratory for Process Engineering, Environment, Biotechnology & Energy, Faculty of Engineering, University of Porto, Porto 4200-465, Portugal*These authors contributed equally to this workCorrespondence: Maria José DiógenesInstitute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Avenida Professor Egas Moniz, Lisbon 1649-028, PortugalEmail diogenes@medicina.ulisboa.ptMaria Carmo PereiraFaculty of Engineering, University of Porto, R. Dr. Roberto Frias, s/n, Porto 4200-465, PortugalEmail mcsp@fe.up.ptIntroduction: Nanoparticles (NPs), as drug delivery systems, appear to be a promising tool for prolonged therapeutic strategies as they allow a controlled drug release over time. However, most of the studies found in the literature simply contemplate the use of a single or low number of dosages with low NPs concentrations. In the context of chronic diseases, like Alzheimer’s disease, cancer or human immunodeficiency virus (HIV), where the therapeutic scheme is also chronic, studies with numerous repeated dosages are often neglected.Methods: We screened different NPs, polymeric and lipid-based, in a repeated-dose toxicity study, to evaluate the safety and tissue distribution of promising nanocarriers to be used in the treatment of long-lasting diseases.Results: After administrating 24 high concentrated doses of the selected NPs intraperitoneally (i.p.) (3 times a week for 2 months), animals have presented NPs accumulation in different tissues. However, neither toxicity, bodyweight changes nor clinical signs of disease were observed.Discussion: This work demonstrates no general adverse effects upon the studied NPs repeated-dose exposure, indicating the most promising NPs to be used in the different therapeutic circumstances, which may be useful in chronic diseases treatment.Keywords: long-lasting treatment, drug delivery systems, nanocarriers, liposomes, solid lipid nanoparticles, PLGA nanoparticlesFonseca-Gomes JLoureiro JATanqueiro SRMouro FMRuivo PCarvalho TSebastião AMDiógenes MJPereira MCDove Medical Pressarticlelong-lasting treatmentdrug delivery systemsnanocarriersliposomessolid lipid nanoparticlesplga nanoparticlesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 8609-8621 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	long-lasting treatment drug delivery systems nanocarriers liposomes solid lipid nanoparticles plga nanoparticles Medicine (General) R5-920
spellingShingle	long-lasting treatment drug delivery systems nanocarriers liposomes solid lipid nanoparticles plga nanoparticles Medicine (General) R5-920 Fonseca-Gomes J Loureiro JA Tanqueiro SR Mouro FM Ruivo P Carvalho T Sebastião AM Diógenes MJ Pereira MC In vivo Bio-Distribution and Toxicity Evaluation of Polymeric and Lipid-Based Nanoparticles: A Potential Approach for Chronic Diseases Treatment
description	João Fonseca-Gomes,1,2,* Joana A Loureiro,3,* Sara R Tanqueiro,1,2 Francisco M Mouro,1,2 Pedro Ruivo,2 Tânia Carvalho,2 Ana M Sebastião,1,2 Maria José Diógenes,1,2,* Maria Carmo Pereira1– 3,* 1Instituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, Lisboa 1649-028, Portugal; 2Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa 1649-028, Portugal; 3LEPABE – Laboratory for Process Engineering, Environment, Biotechnology & Energy, Faculty of Engineering, University of Porto, Porto 4200-465, Portugal*These authors contributed equally to this workCorrespondence: Maria José DiógenesInstitute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Avenida Professor Egas Moniz, Lisbon 1649-028, PortugalEmail diogenes@medicina.ulisboa.ptMaria Carmo PereiraFaculty of Engineering, University of Porto, R. Dr. Roberto Frias, s/n, Porto 4200-465, PortugalEmail mcsp@fe.up.ptIntroduction: Nanoparticles (NPs), as drug delivery systems, appear to be a promising tool for prolonged therapeutic strategies as they allow a controlled drug release over time. However, most of the studies found in the literature simply contemplate the use of a single or low number of dosages with low NPs concentrations. In the context of chronic diseases, like Alzheimer’s disease, cancer or human immunodeficiency virus (HIV), where the therapeutic scheme is also chronic, studies with numerous repeated dosages are often neglected.Methods: We screened different NPs, polymeric and lipid-based, in a repeated-dose toxicity study, to evaluate the safety and tissue distribution of promising nanocarriers to be used in the treatment of long-lasting diseases.Results: After administrating 24 high concentrated doses of the selected NPs intraperitoneally (i.p.) (3 times a week for 2 months), animals have presented NPs accumulation in different tissues. However, neither toxicity, bodyweight changes nor clinical signs of disease were observed.Discussion: This work demonstrates no general adverse effects upon the studied NPs repeated-dose exposure, indicating the most promising NPs to be used in the different therapeutic circumstances, which may be useful in chronic diseases treatment.Keywords: long-lasting treatment, drug delivery systems, nanocarriers, liposomes, solid lipid nanoparticles, PLGA nanoparticles
format	article
author	Fonseca-Gomes J Loureiro JA Tanqueiro SR Mouro FM Ruivo P Carvalho T Sebastião AM Diógenes MJ Pereira MC
author_facet	Fonseca-Gomes J Loureiro JA Tanqueiro SR Mouro FM Ruivo P Carvalho T Sebastião AM Diógenes MJ Pereira MC
author_sort	Fonseca-Gomes J
title	In vivo Bio-Distribution and Toxicity Evaluation of Polymeric and Lipid-Based Nanoparticles: A Potential Approach for Chronic Diseases Treatment
title_short	In vivo Bio-Distribution and Toxicity Evaluation of Polymeric and Lipid-Based Nanoparticles: A Potential Approach for Chronic Diseases Treatment
title_full	In vivo Bio-Distribution and Toxicity Evaluation of Polymeric and Lipid-Based Nanoparticles: A Potential Approach for Chronic Diseases Treatment
title_fullStr	In vivo Bio-Distribution and Toxicity Evaluation of Polymeric and Lipid-Based Nanoparticles: A Potential Approach for Chronic Diseases Treatment
title_full_unstemmed	In vivo Bio-Distribution and Toxicity Evaluation of Polymeric and Lipid-Based Nanoparticles: A Potential Approach for Chronic Diseases Treatment
title_sort	in vivo bio-distribution and toxicity evaluation of polymeric and lipid-based nanoparticles: a potential approach for chronic diseases treatment
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/590eaacda7904dd69c77e11bec12fd0e
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In vivo Bio-Distribution and Toxicity Evaluation of Polymeric and Lipid-Based Nanoparticles: A Potential Approach for Chronic Diseases Treatment

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