Nanosized TiO2-induced reproductive system dysfunction and its mechanism in female mice.

Recent studies have demonstrated nanosized titanium dioxide (nano-TiO2)-induced fertility reduction and ovary injury in animals. To better understand how nano-TiO2 act in mice, female mice were exposed to 2.5, 5, and 10 mg/kg nano-TiO2 by intragastric administration for 90 consecutive days; the ovar...

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Autores principales:	Xiaoyang Zhao, Yuguan Ze, Guodong Gao, Xuezi Sang, Bing Li, Suxin Gui, Lei Sheng, Qingqing Sun, Jie Cheng, Zhe Cheng, Renping Hu, Ling Wang, Fashui Hong
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5910b01456a44bd58df99fdc8a0e0770
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spelling	oai:doaj.org-article:5910b01456a44bd58df99fdc8a0e07702021-11-18T07:51:07ZNanosized TiO2-induced reproductive system dysfunction and its mechanism in female mice.1932-620310.1371/journal.pone.0059378https://doaj.org/article/5910b01456a44bd58df99fdc8a0e07702013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23565150/?tool=EBIhttps://doaj.org/toc/1932-6203Recent studies have demonstrated nanosized titanium dioxide (nano-TiO2)-induced fertility reduction and ovary injury in animals. To better understand how nano-TiO2 act in mice, female mice were exposed to 2.5, 5, and 10 mg/kg nano-TiO2 by intragastric administration for 90 consecutive days; the ovary injuries, fertility, hormone levels, and inflammation-related or follicular atresia-related cytokine expression were investigated. The results showed that nano-TiO2 was deposited in the ovary, resulting in significant reduction of body weight, relative weight of ovary and fertility, alterations of hematological and serum parameters and sex hormone levels, atretic follicle increases, inflammation, and necrosis. Furthermore, nano-TiO2 exposure resulted in marked increases of insulin-like growth factor-binding protein 2, epidermal growth factor, tumor necrosis factor-α, tissue plasminogen activator, interleukin-1β, interleukin -6, Fas, and FasL expression, and significant decreases of insulin-like growth factor-1, luteinizing hormone receptor, inhibin α, and growth differentiation factor 9 expression in mouse ovary. These findings implied that fertility reduction and ovary injury of mice following exposure to nano-TiO2 may be associated with alteration of inflammation-related or follicular atresia-related cytokine expressions, and humans should take great caution when handling nano-TiO2.Xiaoyang ZhaoYuguan ZeGuodong GaoXuezi SangBing LiSuxin GuiLei ShengQingqing SunJie ChengZhe ChengRenping HuLing WangFashui HongPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e59378 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaoyang Zhao Yuguan Ze Guodong Gao Xuezi Sang Bing Li Suxin Gui Lei Sheng Qingqing Sun Jie Cheng Zhe Cheng Renping Hu Ling Wang Fashui Hong Nanosized TiO2-induced reproductive system dysfunction and its mechanism in female mice.
description	Recent studies have demonstrated nanosized titanium dioxide (nano-TiO2)-induced fertility reduction and ovary injury in animals. To better understand how nano-TiO2 act in mice, female mice were exposed to 2.5, 5, and 10 mg/kg nano-TiO2 by intragastric administration for 90 consecutive days; the ovary injuries, fertility, hormone levels, and inflammation-related or follicular atresia-related cytokine expression were investigated. The results showed that nano-TiO2 was deposited in the ovary, resulting in significant reduction of body weight, relative weight of ovary and fertility, alterations of hematological and serum parameters and sex hormone levels, atretic follicle increases, inflammation, and necrosis. Furthermore, nano-TiO2 exposure resulted in marked increases of insulin-like growth factor-binding protein 2, epidermal growth factor, tumor necrosis factor-α, tissue plasminogen activator, interleukin-1β, interleukin -6, Fas, and FasL expression, and significant decreases of insulin-like growth factor-1, luteinizing hormone receptor, inhibin α, and growth differentiation factor 9 expression in mouse ovary. These findings implied that fertility reduction and ovary injury of mice following exposure to nano-TiO2 may be associated with alteration of inflammation-related or follicular atresia-related cytokine expressions, and humans should take great caution when handling nano-TiO2.
format	article
author	Xiaoyang Zhao Yuguan Ze Guodong Gao Xuezi Sang Bing Li Suxin Gui Lei Sheng Qingqing Sun Jie Cheng Zhe Cheng Renping Hu Ling Wang Fashui Hong
author_facet	Xiaoyang Zhao Yuguan Ze Guodong Gao Xuezi Sang Bing Li Suxin Gui Lei Sheng Qingqing Sun Jie Cheng Zhe Cheng Renping Hu Ling Wang Fashui Hong
author_sort	Xiaoyang Zhao
title	Nanosized TiO2-induced reproductive system dysfunction and its mechanism in female mice.
title_short	Nanosized TiO2-induced reproductive system dysfunction and its mechanism in female mice.
title_full	Nanosized TiO2-induced reproductive system dysfunction and its mechanism in female mice.
title_fullStr	Nanosized TiO2-induced reproductive system dysfunction and its mechanism in female mice.
title_full_unstemmed	Nanosized TiO2-induced reproductive system dysfunction and its mechanism in female mice.
title_sort	nanosized tio2-induced reproductive system dysfunction and its mechanism in female mice.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/5910b01456a44bd58df99fdc8a0e0770
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Nanosized TiO2-induced reproductive system dysfunction and its mechanism in female mice.

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