Factors associated with admission to the intensive care unit and mortality in patients with COVID-19, Colombia

<h4>Introduction</h4> Coronavirus disease 2019 (COVID-19) has affected millions of people worldwide, and several sociodemographic variables, comorbidities and care variables have been associated with complications and mortality. <h4>Objective</h4> To identify the factors asso...

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Autores principales:	Jorge Enrique Machado-Alba, Luis Fernando Valladales-Restrepo, Manuel Enrique Machado-Duque, Andrés Gaviria-Mendoza, Nicolás Sánchez-Ramírez, Andrés Felipe Usma-Valencia, Esteban Rodríguez-Martínez, Eliana Rengifo-Franco, Víctor Hugo Forero-Supelano, Diego Mauricio Gómez-Ramirez, Alejandra Sabogal-Ortiz
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/591438e196c44ed7bb539b5924a97551
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spelling	oai:doaj.org-article:591438e196c44ed7bb539b5924a975512021-11-25T06:19:30ZFactors associated with admission to the intensive care unit and mortality in patients with COVID-19, Colombia1932-6203https://doaj.org/article/591438e196c44ed7bb539b5924a975512021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604321/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Introduction</h4> Coronavirus disease 2019 (COVID-19) has affected millions of people worldwide, and several sociodemographic variables, comorbidities and care variables have been associated with complications and mortality. <h4>Objective</h4> To identify the factors associated with admission to intensive care units (ICUs) and mortality in patients with COVID-19 from 4 clinics in Colombia. <h4>Methods</h4> This was a follow-up study of a cohort of patients diagnosed with COVID-19 between March and August 2020. Sociodemographic, clinical (Charlson comorbidity index and NEWS 2 score) and pharmacological variables were identified. Multivariate analyses were performed to identify variables associated with the risk of admission to the ICU and death (p<0.05). <h4>Results</h4> A total of 780 patients were analyzed, with a median age of 57.0 years; 61.2% were male. On admission, 54.9% were classified as severely ill, 65.3% were diagnosed with acute respiratory distress syndrome, 32.4% were admitted to the ICU, and 26.0% died. The factors associated with a greater likelihood of ICU admission were severe pneumonia (OR: 9.86; 95%CI:5.99–16.23), each 1-point increase in the NEWS 2 score (OR:1.09; 95%CI:1.002–1.19), history of ischemic heart disease (OR:3.24; 95%CI:1.16–9.00), and chronic obstructive pulmonary disease (OR:2.07; 95%CI:1.09–3.90). The risk of dying increased in those older than 65 years (OR:3.08; 95%CI:1.66–5.71), in patients with acute renal failure (OR:6.96; 95%CI:4.41–11.78), admitted to the ICU (OR:6.31; 95%CI:3.63–10.95), and for each 1-point increase in the Charlson comorbidity index (OR:1.16; 95%CI:1.002–1.35). <h4>Conclusions</h4> Factors related to increasing the probability of requiring ICU care or dying in patients with COVID-19 were identified, facilitating the development of anticipatory intervention measures that favor comprehensive care and improve patient prognosis.Jorge Enrique Machado-AlbaLuis Fernando Valladales-RestrepoManuel Enrique Machado-DuqueAndrés Gaviria-MendozaNicolás Sánchez-RamírezAndrés Felipe Usma-ValenciaEsteban Rodríguez-MartínezEliana Rengifo-FrancoVíctor Hugo Forero-SupelanoDiego Mauricio Gómez-RamirezAlejandra Sabogal-OrtizPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jorge Enrique Machado-Alba Luis Fernando Valladales-Restrepo Manuel Enrique Machado-Duque Andrés Gaviria-Mendoza Nicolás Sánchez-Ramírez Andrés Felipe Usma-Valencia Esteban Rodríguez-Martínez Eliana Rengifo-Franco Víctor Hugo Forero-Supelano Diego Mauricio Gómez-Ramirez Alejandra Sabogal-Ortiz Factors associated with admission to the intensive care unit and mortality in patients with COVID-19, Colombia
description	<h4>Introduction</h4> Coronavirus disease 2019 (COVID-19) has affected millions of people worldwide, and several sociodemographic variables, comorbidities and care variables have been associated with complications and mortality. <h4>Objective</h4> To identify the factors associated with admission to intensive care units (ICUs) and mortality in patients with COVID-19 from 4 clinics in Colombia. <h4>Methods</h4> This was a follow-up study of a cohort of patients diagnosed with COVID-19 between March and August 2020. Sociodemographic, clinical (Charlson comorbidity index and NEWS 2 score) and pharmacological variables were identified. Multivariate analyses were performed to identify variables associated with the risk of admission to the ICU and death (p<0.05). <h4>Results</h4> A total of 780 patients were analyzed, with a median age of 57.0 years; 61.2% were male. On admission, 54.9% were classified as severely ill, 65.3% were diagnosed with acute respiratory distress syndrome, 32.4% were admitted to the ICU, and 26.0% died. The factors associated with a greater likelihood of ICU admission were severe pneumonia (OR: 9.86; 95%CI:5.99–16.23), each 1-point increase in the NEWS 2 score (OR:1.09; 95%CI:1.002–1.19), history of ischemic heart disease (OR:3.24; 95%CI:1.16–9.00), and chronic obstructive pulmonary disease (OR:2.07; 95%CI:1.09–3.90). The risk of dying increased in those older than 65 years (OR:3.08; 95%CI:1.66–5.71), in patients with acute renal failure (OR:6.96; 95%CI:4.41–11.78), admitted to the ICU (OR:6.31; 95%CI:3.63–10.95), and for each 1-point increase in the Charlson comorbidity index (OR:1.16; 95%CI:1.002–1.35). <h4>Conclusions</h4> Factors related to increasing the probability of requiring ICU care or dying in patients with COVID-19 were identified, facilitating the development of anticipatory intervention measures that favor comprehensive care and improve patient prognosis.
format	article
author	Jorge Enrique Machado-Alba Luis Fernando Valladales-Restrepo Manuel Enrique Machado-Duque Andrés Gaviria-Mendoza Nicolás Sánchez-Ramírez Andrés Felipe Usma-Valencia Esteban Rodríguez-Martínez Eliana Rengifo-Franco Víctor Hugo Forero-Supelano Diego Mauricio Gómez-Ramirez Alejandra Sabogal-Ortiz
author_facet	Jorge Enrique Machado-Alba Luis Fernando Valladales-Restrepo Manuel Enrique Machado-Duque Andrés Gaviria-Mendoza Nicolás Sánchez-Ramírez Andrés Felipe Usma-Valencia Esteban Rodríguez-Martínez Eliana Rengifo-Franco Víctor Hugo Forero-Supelano Diego Mauricio Gómez-Ramirez Alejandra Sabogal-Ortiz
author_sort	Jorge Enrique Machado-Alba
title	Factors associated with admission to the intensive care unit and mortality in patients with COVID-19, Colombia
title_short	Factors associated with admission to the intensive care unit and mortality in patients with COVID-19, Colombia
title_full	Factors associated with admission to the intensive care unit and mortality in patients with COVID-19, Colombia
title_fullStr	Factors associated with admission to the intensive care unit and mortality in patients with COVID-19, Colombia
title_full_unstemmed	Factors associated with admission to the intensive care unit and mortality in patients with COVID-19, Colombia
title_sort	factors associated with admission to the intensive care unit and mortality in patients with covid-19, colombia
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/591438e196c44ed7bb539b5924a97551
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Factors associated with admission to the intensive care unit and mortality in patients with COVID-19, Colombia

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