Off-Label Treatments for Pediatric Psoriasis: Lessons for the Clinic

Morten B Haulrig,1 Claus Zachariae,1,2 Lone Skov1,2 1Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, DK-2900, Denmark; 2Copenhagen Research Group for Inflammatory Skin (CORGIS), Hellerup, DenmarkCorrespondence: Morten B HaulrigDepartment of De...

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Autores principales:	Haulrig MB, Zachariae C, Skov L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	psoriasis unapproved treatment childhood adolescents Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/5915512e39f9488c99f0a299575a2fa6
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spelling	oai:doaj.org-article:5915512e39f9488c99f0a299575a2fa62021-12-02T13:30:40ZOff-Label Treatments for Pediatric Psoriasis: Lessons for the Clinic2230-326Xhttps://doaj.org/article/5915512e39f9488c99f0a299575a2fa62021-02-01T00:00:00Zhttps://www.dovepress.com/off-label-treatments-for-pediatric-psoriasis-lessons-for-the-clinic-peer-reviewed-article-PTThttps://doaj.org/toc/2230-326XMorten B Haulrig,1 Claus Zachariae,1,2 Lone Skov1,2 1Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, DK-2900, Denmark; 2Copenhagen Research Group for Inflammatory Skin (CORGIS), Hellerup, DenmarkCorrespondence: Morten B HaulrigDepartment of Dermatology and Allergy, Herlev and Gentofte Hospital, Gentofte Hospitalsvej 15, DK-2900, DenmarkTel +45 38 67 31 32Fax +45 38 67 71 18Email Morten.bahrt.haulrig@regionh.dkAbstract: Psoriasis is a chronic inflammatory skin disease that affects up to 1.2% of children and adolescents. The treatment options for childhood psoriasis are often based on the same principles as in adults. However, most data on safety and efficacy derive from adult studies, and only a few of the frequently used treatments have achieved approval for use in children. The aim of this study was to review the current literature on off-label treatments for psoriasis in children and adolescents. We searched PubMed and identified 50 studies on off-label treatments. Of these, 23 studies were clinical trials (four randomized). There are only a small number of available studies on off-label treatments for children and adolescents with psoriasis, and many of these are retrospective reviews with few participants. Despite the current lack of studies, we still recommend the use of unapproved treatments since we have clinical experience with treatments such as topical corticosteroids, vitamin D analogs, and methotrexate that have shown promising effects. Regular clinical trials are needed to investigate the safety and efficacy of unapproved treatments. Due to The Pediatric Investigation Plans issued by The European Union, new drugs developed by pharmaceutical companies are required to undergo clinical trials in a pediatric population to get their application for marketing authorization processed. This will hopefully lead to much more data on the efficacy and safety of the new treatments, including treatments for children and adolescents with psoriasis.Keywords: psoriasis, unapproved treatment, childhood, adolescentsHaulrig MBZachariae CSkov LDove Medical Pressarticlepsoriasisunapproved treatmentchildhoodadolescentsDermatologyRL1-803ENPsoriasis: Targets and Therapy, Vol Volume 11, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	psoriasis unapproved treatment childhood adolescents Dermatology RL1-803
spellingShingle	psoriasis unapproved treatment childhood adolescents Dermatology RL1-803 Haulrig MB Zachariae C Skov L Off-Label Treatments for Pediatric Psoriasis: Lessons for the Clinic
description	Morten B Haulrig,1 Claus Zachariae,1,2 Lone Skov1,2 1Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, DK-2900, Denmark; 2Copenhagen Research Group for Inflammatory Skin (CORGIS), Hellerup, DenmarkCorrespondence: Morten B HaulrigDepartment of Dermatology and Allergy, Herlev and Gentofte Hospital, Gentofte Hospitalsvej 15, DK-2900, DenmarkTel +45 38 67 31 32Fax +45 38 67 71 18Email Morten.bahrt.haulrig@regionh.dkAbstract: Psoriasis is a chronic inflammatory skin disease that affects up to 1.2% of children and adolescents. The treatment options for childhood psoriasis are often based on the same principles as in adults. However, most data on safety and efficacy derive from adult studies, and only a few of the frequently used treatments have achieved approval for use in children. The aim of this study was to review the current literature on off-label treatments for psoriasis in children and adolescents. We searched PubMed and identified 50 studies on off-label treatments. Of these, 23 studies were clinical trials (four randomized). There are only a small number of available studies on off-label treatments for children and adolescents with psoriasis, and many of these are retrospective reviews with few participants. Despite the current lack of studies, we still recommend the use of unapproved treatments since we have clinical experience with treatments such as topical corticosteroids, vitamin D analogs, and methotrexate that have shown promising effects. Regular clinical trials are needed to investigate the safety and efficacy of unapproved treatments. Due to The Pediatric Investigation Plans issued by The European Union, new drugs developed by pharmaceutical companies are required to undergo clinical trials in a pediatric population to get their application for marketing authorization processed. This will hopefully lead to much more data on the efficacy and safety of the new treatments, including treatments for children and adolescents with psoriasis.Keywords: psoriasis, unapproved treatment, childhood, adolescents
format	article
author	Haulrig MB Zachariae C Skov L
author_facet	Haulrig MB Zachariae C Skov L
author_sort	Haulrig MB
title	Off-Label Treatments for Pediatric Psoriasis: Lessons for the Clinic
title_short	Off-Label Treatments for Pediatric Psoriasis: Lessons for the Clinic
title_full	Off-Label Treatments for Pediatric Psoriasis: Lessons for the Clinic
title_fullStr	Off-Label Treatments for Pediatric Psoriasis: Lessons for the Clinic
title_full_unstemmed	Off-Label Treatments for Pediatric Psoriasis: Lessons for the Clinic
title_sort	off-label treatments for pediatric psoriasis: lessons for the clinic
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/5915512e39f9488c99f0a299575a2fa6
work_keys_str_mv	AT haulrigmb offlabeltreatmentsforpediatricpsoriasislessonsfortheclinic AT zachariaec offlabeltreatmentsforpediatricpsoriasislessonsfortheclinic AT skovl offlabeltreatmentsforpediatricpsoriasislessonsfortheclinic
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Off-Label Treatments for Pediatric Psoriasis: Lessons for the Clinic

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