Teasing apart the cell death pathways in HIV pathogenesis

The progressive loss of CD4 + T cells has been recognised as being central to HIV-1 pathogenesis, however a precise understanding of the underlying mechanisms and, consequently, improved therapies have yet to be achieved. Zhang et al. have recently shown in HIV-1 patients that the NLRP3 inflammasome...

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Autor principal:	Karli Montague-Cardoso
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/591957e25e714d70998275dc5a8be073
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spelling	oai:doaj.org-article:591957e25e714d70998275dc5a8be0732021-12-02T16:45:14ZTeasing apart the cell death pathways in HIV pathogenesis10.1038/s42003-021-02077-22399-3642https://doaj.org/article/591957e25e714d70998275dc5a8be0732021-04-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02077-2https://doaj.org/toc/2399-3642The progressive loss of CD4 + T cells has been recognised as being central to HIV-1 pathogenesis, however a precise understanding of the underlying mechanisms and, consequently, improved therapies have yet to be achieved. Zhang et al. have recently shown in HIV-1 patients that the NLRP3 inflammasome pathway, which plays a key role in innate immunity, is a crucial mediator of the loss of CD4 + T cells. This advance could inform the development of innovative anti-HIV-1 therapies.Karli Montague-CardosoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Karli Montague-Cardoso Teasing apart the cell death pathways in HIV pathogenesis
description	The progressive loss of CD4 + T cells has been recognised as being central to HIV-1 pathogenesis, however a precise understanding of the underlying mechanisms and, consequently, improved therapies have yet to be achieved. Zhang et al. have recently shown in HIV-1 patients that the NLRP3 inflammasome pathway, which plays a key role in innate immunity, is a crucial mediator of the loss of CD4 + T cells. This advance could inform the development of innovative anti-HIV-1 therapies.
format	article
author	Karli Montague-Cardoso
author_facet	Karli Montague-Cardoso
author_sort	Karli Montague-Cardoso
title	Teasing apart the cell death pathways in HIV pathogenesis
title_short	Teasing apart the cell death pathways in HIV pathogenesis
title_full	Teasing apart the cell death pathways in HIV pathogenesis
title_fullStr	Teasing apart the cell death pathways in HIV pathogenesis
title_full_unstemmed	Teasing apart the cell death pathways in HIV pathogenesis
title_sort	teasing apart the cell death pathways in hiv pathogenesis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/591957e25e714d70998275dc5a8be073
work_keys_str_mv	AT karlimontaguecardoso teasingapartthecelldeathpathwaysinhivpathogenesis
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Teasing apart the cell death pathways in HIV pathogenesis

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