Contribution of common PCSK1 genetic variants to obesity in 8,359 subjects from multi-ethnic American population.

Common PCSK1 variants (notably rs6232 and rs6235) have been shown to be associated with obesity in European, Asian and Mexican populations. To determine whether common PCSK1 variants contribute to obesity in American population, we conducted association analyses in 8,359 subjects using two multi-eth...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hélène Choquet, Jay Kasberger, Ajna Hamidovic, Eric Jorgenson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/591b00b8da2c4e65bc68168f6fcfde02
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:591b00b8da2c4e65bc68168f6fcfde02
record_format	dspace
spelling	oai:doaj.org-article:591b00b8da2c4e65bc68168f6fcfde022021-11-18T07:56:01ZContribution of common PCSK1 genetic variants to obesity in 8,359 subjects from multi-ethnic American population.1932-620310.1371/journal.pone.0057857https://doaj.org/article/591b00b8da2c4e65bc68168f6fcfde022013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23451278/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Common PCSK1 variants (notably rs6232 and rs6235) have been shown to be associated with obesity in European, Asian and Mexican populations. To determine whether common PCSK1 variants contribute to obesity in American population, we conducted association analyses in 8,359 subjects using two multi-ethnic American studies: the Coronary Artery Risk Development in Young Adults (CARDIA) study and the Multi-Ethnic Study of Atherosclerosis (MESA). By evaluating the contribution of rs6232 and rs6235 in each ethnic group, we found that in European-American subjects from CARDIA, only rs6232 was associated with BMI (P = 0.006) and obesity (P = 0.018) but also increased the obesity incidence during the 20 years of follow-up (HR = 1.53 [1.07-2.19], P = 0.019). Alternatively, in African-American subjects from CARDIA, rs6235 was associated with BMI (P = 0.028) and obesity (P = 0.018). Further, by combining the two case-control ethnic groups from the CARDIA study in a meta-analysis, association between rs6235 and obesity risk remained significant (OR = 1.23 [1.05-1.45], P = 9.5×10(-3)). However, neither rs6232 nor rs6235 was associated with BMI or obesity in the MESA study. Interestingly, rs6232 was associated with BMI (P = 4.2×10(-3)) and obesity (P = 3.4×10(-3)) in the younger European-American group combining samples from the both studies [less than median age (53 years)], but not among the older age group (P = 0.756 and P = 0.935 for BMI and obesity, respectively). By combining all the case-control ethnic groups from CARDIA and MESA in a meta-analysis, we found no significant association for the both variants and obesity risk. Finally, by exploring the full PCSK1 locus, we observed that no variant remained significant after correction for multiple testing. These results indicate that common PCSK1 variants (notably rs6232 and rs6235) contribute modestly to obesity in multi-ethnic American population. Further, these results suggest that the association of rs6232 with obesity may be age-dependent in European-Americans. However, multiple replication studies in multi-ethnic American population are needed to confirm our findings.Hélène ChoquetJay KasbergerAjna HamidovicEric JorgensonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e57857 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hélène Choquet Jay Kasberger Ajna Hamidovic Eric Jorgenson Contribution of common PCSK1 genetic variants to obesity in 8,359 subjects from multi-ethnic American population.
description	Common PCSK1 variants (notably rs6232 and rs6235) have been shown to be associated with obesity in European, Asian and Mexican populations. To determine whether common PCSK1 variants contribute to obesity in American population, we conducted association analyses in 8,359 subjects using two multi-ethnic American studies: the Coronary Artery Risk Development in Young Adults (CARDIA) study and the Multi-Ethnic Study of Atherosclerosis (MESA). By evaluating the contribution of rs6232 and rs6235 in each ethnic group, we found that in European-American subjects from CARDIA, only rs6232 was associated with BMI (P = 0.006) and obesity (P = 0.018) but also increased the obesity incidence during the 20 years of follow-up (HR = 1.53 [1.07-2.19], P = 0.019). Alternatively, in African-American subjects from CARDIA, rs6235 was associated with BMI (P = 0.028) and obesity (P = 0.018). Further, by combining the two case-control ethnic groups from the CARDIA study in a meta-analysis, association between rs6235 and obesity risk remained significant (OR = 1.23 [1.05-1.45], P = 9.5×10(-3)). However, neither rs6232 nor rs6235 was associated with BMI or obesity in the MESA study. Interestingly, rs6232 was associated with BMI (P = 4.2×10(-3)) and obesity (P = 3.4×10(-3)) in the younger European-American group combining samples from the both studies [less than median age (53 years)], but not among the older age group (P = 0.756 and P = 0.935 for BMI and obesity, respectively). By combining all the case-control ethnic groups from CARDIA and MESA in a meta-analysis, we found no significant association for the both variants and obesity risk. Finally, by exploring the full PCSK1 locus, we observed that no variant remained significant after correction for multiple testing. These results indicate that common PCSK1 variants (notably rs6232 and rs6235) contribute modestly to obesity in multi-ethnic American population. Further, these results suggest that the association of rs6232 with obesity may be age-dependent in European-Americans. However, multiple replication studies in multi-ethnic American population are needed to confirm our findings.
format	article
author	Hélène Choquet Jay Kasberger Ajna Hamidovic Eric Jorgenson
author_facet	Hélène Choquet Jay Kasberger Ajna Hamidovic Eric Jorgenson
author_sort	Hélène Choquet
title	Contribution of common PCSK1 genetic variants to obesity in 8,359 subjects from multi-ethnic American population.
title_short	Contribution of common PCSK1 genetic variants to obesity in 8,359 subjects from multi-ethnic American population.
title_full	Contribution of common PCSK1 genetic variants to obesity in 8,359 subjects from multi-ethnic American population.
title_fullStr	Contribution of common PCSK1 genetic variants to obesity in 8,359 subjects from multi-ethnic American population.
title_full_unstemmed	Contribution of common PCSK1 genetic variants to obesity in 8,359 subjects from multi-ethnic American population.
title_sort	contribution of common pcsk1 genetic variants to obesity in 8,359 subjects from multi-ethnic american population.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/591b00b8da2c4e65bc68168f6fcfde02
work_keys_str_mv	AT helenechoquet contributionofcommonpcsk1geneticvariantstoobesityin8359subjectsfrommultiethnicamericanpopulation AT jaykasberger contributionofcommonpcsk1geneticvariantstoobesityin8359subjectsfrommultiethnicamericanpopulation AT ajnahamidovic contributionofcommonpcsk1geneticvariantstoobesityin8359subjectsfrommultiethnicamericanpopulation AT ericjorgenson contributionofcommonpcsk1geneticvariantstoobesityin8359subjectsfrommultiethnicamericanpopulation
_version_	1718422729985622016

Contribution of common PCSK1 genetic variants to obesity in 8,359 subjects from multi-ethnic American population.

Ejemplares similares