Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer

Changes in the DNA methylation status are commonly observed in cancer but their impact on cancer development is unclear. Here, combining DNA methylation and expression profiles from a murine model of hepatocellular carcinoma with those from human samples, the authors report an epigenetic reprogrammi...

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Autores principales:	Maria Arechederra, Fabrice Daian, Annie Yim, Sehrish K. Bazai, Sylvie Richelme, Rosanna Dono, Andrew J. Saurin, Bianca H. Habermann, Flavio Maina
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/591c80cc94cc4a5b8b2993441adc4c57
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spelling	oai:doaj.org-article:591c80cc94cc4a5b8b2993441adc4c572021-12-02T17:32:47ZHypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer10.1038/s41467-018-05550-52041-1723https://doaj.org/article/591c80cc94cc4a5b8b2993441adc4c572018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05550-5https://doaj.org/toc/2041-1723Changes in the DNA methylation status are commonly observed in cancer but their impact on cancer development is unclear. Here, combining DNA methylation and expression profiles from a murine model of hepatocellular carcinoma with those from human samples, the authors report an epigenetic reprogramming process ensuring increased dosage of an “oncogene module”.Maria ArechederraFabrice DaianAnnie YimSehrish K. BazaiSylvie RichelmeRosanna DonoAndrew J. SaurinBianca H. HabermannFlavio MainaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maria Arechederra Fabrice Daian Annie Yim Sehrish K. Bazai Sylvie Richelme Rosanna Dono Andrew J. Saurin Bianca H. Habermann Flavio Maina Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer
description	Changes in the DNA methylation status are commonly observed in cancer but their impact on cancer development is unclear. Here, combining DNA methylation and expression profiles from a murine model of hepatocellular carcinoma with those from human samples, the authors report an epigenetic reprogramming process ensuring increased dosage of an “oncogene module”.
format	article
author	Maria Arechederra Fabrice Daian Annie Yim Sehrish K. Bazai Sylvie Richelme Rosanna Dono Andrew J. Saurin Bianca H. Habermann Flavio Maina
author_facet	Maria Arechederra Fabrice Daian Annie Yim Sehrish K. Bazai Sylvie Richelme Rosanna Dono Andrew J. Saurin Bianca H. Habermann Flavio Maina
author_sort	Maria Arechederra
title	Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer
title_short	Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer
title_full	Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer
title_fullStr	Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer
title_full_unstemmed	Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer
title_sort	hypermethylation of gene body cpg islands predicts high dosage of functional oncogenes in liver cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/591c80cc94cc4a5b8b2993441adc4c57
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Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer

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