Exploring the Biomechanical Properties of the Human Cornea In Vivo Based on Corvis ST

Purpose: The aim of this study was to provide a method to determine corneal nonlinear viscoelastic properties based on the output data of corneal visualization Scheimpflug technology (Corvis ST).Methods: The Corvis ST data from 18 eyes of 12 healthy humans were collected. Based on the air-puff press...

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Autores principales:	Di Zhang, Haixia Zhang, Lei Tian, Yan Zheng, Caiyun Fu, Changbin Zhai, Lin Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cornea corneal biomechanical properties in vivo CorVis ST visco-hyperelastic model Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/591dfaa5b78e46aa8a02818e803049c7
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spelling	oai:doaj.org-article:591dfaa5b78e46aa8a02818e803049c72021-11-17T05:58:51ZExploring the Biomechanical Properties of the Human Cornea In Vivo Based on Corvis ST2296-418510.3389/fbioe.2021.771763https://doaj.org/article/591dfaa5b78e46aa8a02818e803049c72021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.771763/fullhttps://doaj.org/toc/2296-4185Purpose: The aim of this study was to provide a method to determine corneal nonlinear viscoelastic properties based on the output data of corneal visualization Scheimpflug technology (Corvis ST).Methods: The Corvis ST data from 18 eyes of 12 healthy humans were collected. Based on the air-puff pressure and the corneal displacement from the Corvis ST test of normal human eyes, the work done by the air-puff attaining the whole corneal displacement was obtained. By applying a visco-hyperelastic strain energy density function of the cornea, in which the first-order Prony relaxation function and the first-order Ogden strain energy were employed, the corneal strain energy during the Corvis ST test was calculated. Then the work done by the air-puff attaining the whole corneal displacement was completely regarded as the strain energy of the cornea. The identification of the nonlinear viscoelastic parameters was carried out by optimizing the sum of difference squares of the work and the strain energy using the genetic algorithm.Results: The visco-hyperelastic model gave a good fit to the data of corneal strain energy with time during the Corvis ST test (R2 > 0.95). The determined Ogden model parameter μ ranged from 0.42 to 0.74 MPa, and α ranged from 32.76 to 55.63. The parameters A and τ in the first-order Prony function were 0.09–0.36 and 1.21–1.95 ms, respectively.Conclusion: It is feasible to determine the corneal nonlinear viscoelastic properties based on the corneal contour information and air-puff pressure of the Corvis ST test.Di ZhangDi ZhangHaixia ZhangHaixia ZhangLei TianLei TianYan ZhengCaiyun FuChangbin ZhaiLin LiLin LiFrontiers Media S.A.articlecorneacorneal biomechanical propertiesin vivoCorVis STvisco-hyperelastic modelBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cornea corneal biomechanical properties in vivo CorVis ST visco-hyperelastic model Biotechnology TP248.13-248.65
spellingShingle	cornea corneal biomechanical properties in vivo CorVis ST visco-hyperelastic model Biotechnology TP248.13-248.65 Di Zhang Di Zhang Haixia Zhang Haixia Zhang Lei Tian Lei Tian Yan Zheng Caiyun Fu Changbin Zhai Lin Li Lin Li Exploring the Biomechanical Properties of the Human Cornea In Vivo Based on Corvis ST
description	Purpose: The aim of this study was to provide a method to determine corneal nonlinear viscoelastic properties based on the output data of corneal visualization Scheimpflug technology (Corvis ST).Methods: The Corvis ST data from 18 eyes of 12 healthy humans were collected. Based on the air-puff pressure and the corneal displacement from the Corvis ST test of normal human eyes, the work done by the air-puff attaining the whole corneal displacement was obtained. By applying a visco-hyperelastic strain energy density function of the cornea, in which the first-order Prony relaxation function and the first-order Ogden strain energy were employed, the corneal strain energy during the Corvis ST test was calculated. Then the work done by the air-puff attaining the whole corneal displacement was completely regarded as the strain energy of the cornea. The identification of the nonlinear viscoelastic parameters was carried out by optimizing the sum of difference squares of the work and the strain energy using the genetic algorithm.Results: The visco-hyperelastic model gave a good fit to the data of corneal strain energy with time during the Corvis ST test (R2 > 0.95). The determined Ogden model parameter μ ranged from 0.42 to 0.74 MPa, and α ranged from 32.76 to 55.63. The parameters A and τ in the first-order Prony function were 0.09–0.36 and 1.21–1.95 ms, respectively.Conclusion: It is feasible to determine the corneal nonlinear viscoelastic properties based on the corneal contour information and air-puff pressure of the Corvis ST test.
format	article
author	Di Zhang Di Zhang Haixia Zhang Haixia Zhang Lei Tian Lei Tian Yan Zheng Caiyun Fu Changbin Zhai Lin Li Lin Li
author_facet	Di Zhang Di Zhang Haixia Zhang Haixia Zhang Lei Tian Lei Tian Yan Zheng Caiyun Fu Changbin Zhai Lin Li Lin Li
author_sort	Di Zhang
title	Exploring the Biomechanical Properties of the Human Cornea In Vivo Based on Corvis ST
title_short	Exploring the Biomechanical Properties of the Human Cornea In Vivo Based on Corvis ST
title_full	Exploring the Biomechanical Properties of the Human Cornea In Vivo Based on Corvis ST
title_fullStr	Exploring the Biomechanical Properties of the Human Cornea In Vivo Based on Corvis ST
title_full_unstemmed	Exploring the Biomechanical Properties of the Human Cornea In Vivo Based on Corvis ST
title_sort	exploring the biomechanical properties of the human cornea in vivo based on corvis st
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/591dfaa5b78e46aa8a02818e803049c7
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Exploring the Biomechanical Properties of the Human Cornea In Vivo Based on Corvis ST

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