Neuroinflammation as a Therapeutic Target in Retinitis Pigmentosa and Quercetin as Its Potential Modulator

The retina is a multilayer neuronal tissue located in the back of the eye that transduces the environmental light into a neural impulse. Many eye diseases caused by endogenous or exogenous harm lead to retina degeneration with neuroinflammation being a major hallmark of these pathologies. One of the...

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Autores principales:	Joseph Thomas Ortega, Beata Jastrzebska
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	flavonoid inflammation photoreceptor retinitis pigmentosa rhodopsin Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/591efddc60504f838b289158b79a7644
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spelling	oai:doaj.org-article:591efddc60504f838b289158b79a76442021-11-25T18:42:07ZNeuroinflammation as a Therapeutic Target in Retinitis Pigmentosa and Quercetin as Its Potential Modulator10.3390/pharmaceutics131119351999-4923https://doaj.org/article/591efddc60504f838b289158b79a76442021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1935https://doaj.org/toc/1999-4923The retina is a multilayer neuronal tissue located in the back of the eye that transduces the environmental light into a neural impulse. Many eye diseases caused by endogenous or exogenous harm lead to retina degeneration with neuroinflammation being a major hallmark of these pathologies. One of the most prevalent retinopathies is retinitis pigmentosa (RP), a clinically and genetically heterogeneous hereditary disorder that causes a decline in vision and eventually blindness. Most RP cases are related to mutations in the rod visual receptor, rhodopsin. The mutant protein triggers inflammatory reactions resulting in the activation of microglia to clear degenerating photoreceptor cells. However, sustained insult caused by the abnormal genetic background exacerbates the inflammatory response and increases oxidative stress in the retina, leading to a decline in rod photoreceptors followed by cone photoreceptors. Thus, inhibition of inflammation in RP has received attention and has been explored as a potential therapeutic strategy. However, pharmacological modulation of the retinal inflammatory response in combination with rhodopsin small molecule chaperones would likely be a more advantageous therapeutic approach to combat RP. Flavonoids, which exhibit antioxidant and anti-inflammatory properties, and modulate the stability and folding of rod opsin, could be a valid option in developing treatment strategies against RP.Joseph Thomas OrtegaBeata JastrzebskaMDPI AGarticleflavonoidinflammationphotoreceptorretinitis pigmentosarhodopsinPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1935, p 1935 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	flavonoid inflammation photoreceptor retinitis pigmentosa rhodopsin Pharmacy and materia medica RS1-441
spellingShingle	flavonoid inflammation photoreceptor retinitis pigmentosa rhodopsin Pharmacy and materia medica RS1-441 Joseph Thomas Ortega Beata Jastrzebska Neuroinflammation as a Therapeutic Target in Retinitis Pigmentosa and Quercetin as Its Potential Modulator
description	The retina is a multilayer neuronal tissue located in the back of the eye that transduces the environmental light into a neural impulse. Many eye diseases caused by endogenous or exogenous harm lead to retina degeneration with neuroinflammation being a major hallmark of these pathologies. One of the most prevalent retinopathies is retinitis pigmentosa (RP), a clinically and genetically heterogeneous hereditary disorder that causes a decline in vision and eventually blindness. Most RP cases are related to mutations in the rod visual receptor, rhodopsin. The mutant protein triggers inflammatory reactions resulting in the activation of microglia to clear degenerating photoreceptor cells. However, sustained insult caused by the abnormal genetic background exacerbates the inflammatory response and increases oxidative stress in the retina, leading to a decline in rod photoreceptors followed by cone photoreceptors. Thus, inhibition of inflammation in RP has received attention and has been explored as a potential therapeutic strategy. However, pharmacological modulation of the retinal inflammatory response in combination with rhodopsin small molecule chaperones would likely be a more advantageous therapeutic approach to combat RP. Flavonoids, which exhibit antioxidant and anti-inflammatory properties, and modulate the stability and folding of rod opsin, could be a valid option in developing treatment strategies against RP.
format	article
author	Joseph Thomas Ortega Beata Jastrzebska
author_facet	Joseph Thomas Ortega Beata Jastrzebska
author_sort	Joseph Thomas Ortega
title	Neuroinflammation as a Therapeutic Target in Retinitis Pigmentosa and Quercetin as Its Potential Modulator
title_short	Neuroinflammation as a Therapeutic Target in Retinitis Pigmentosa and Quercetin as Its Potential Modulator
title_full	Neuroinflammation as a Therapeutic Target in Retinitis Pigmentosa and Quercetin as Its Potential Modulator
title_fullStr	Neuroinflammation as a Therapeutic Target in Retinitis Pigmentosa and Quercetin as Its Potential Modulator
title_full_unstemmed	Neuroinflammation as a Therapeutic Target in Retinitis Pigmentosa and Quercetin as Its Potential Modulator
title_sort	neuroinflammation as a therapeutic target in retinitis pigmentosa and quercetin as its potential modulator
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/591efddc60504f838b289158b79a7644
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_version_	1718410772602683392

Neuroinflammation as a Therapeutic Target in Retinitis Pigmentosa and Quercetin as Its Potential Modulator

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