Comprehensive treatment of cervical intraepithelial neoplasia
Aim. To study the effectiveness of the use of Neovir (sodium oxodihydroacridinyl acetates) as immunomodulatory and antiviral drug in the comprehensive treatment of various grade cervical intraepithelial neoplasia (CIN). Study design: prospective comparative study. Materials and methods. The study...
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IP Berlin A.V.
2021
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oai:doaj.org-article:591f8831abca4f2fbc9770db0aabf9bf2021-12-02T19:22:24ZComprehensive treatment of cervical intraepithelial neoplasia2079-56962079-583110.26442/20795696.2021.1.200670https://doaj.org/article/591f8831abca4f2fbc9770db0aabf9bf2021-03-01T00:00:00Zhttps://gynecology.orscience.ru/2079-5831/article/viewFile/63736/46700https://doaj.org/toc/2079-5696https://doaj.org/toc/2079-5831Aim. To study the effectiveness of the use of Neovir (sodium oxodihydroacridinyl acetates) as immunomodulatory and antiviral drug in the comprehensive treatment of various grade cervical intraepithelial neoplasia (CIN). Study design: prospective comparative study. Materials and methods. The study included 60 patients (mean age 34.78.2 years) with morphologically verified various grade CIN, who were received comprehensive treatment, including the use of Neovir (sodium oxodihydroacridinyl acetate) as the drug with immunomodulatory and antiviral activity, 250 mg/2 ml intramuscularly every 48 hours, 10 injections before (group 1) or after (group 2) multi-stage radiosurgical diagnostic and treatment procedure or only a similar surgical intervention (group 3). All patients underwent complete clinical, morphological and laboratory examination with monitoring for the presence of high-risk human papillomavirus (HPV) in the cervical scraping and the dynamics of peripheral blood lymphocyte subpopulations. Results. Dynamic follow-up showed that in a month after surgery, patients who were treated with radiosurgical resection as monotherapy (group 3) had the lowest rate of complete epithelialization of the cervical stump 30.0% vs 55.0 and 65,0% in the group 1 and group 2 respectively. In this group, the proportion of patients with persistent viral infection was 1.52 times higher than in the groups where an antiviral drug was used in combination with radiosurgical intervention 35.7% vs 17.6 and 22.2% in the group 1 and group2, respectively. In 6 months, elimination of high-risk HPV in groups with comprehensive treatment reached 94.5 in the group 1 and 94.1% in the group 2 (p0.05) vs 78.6% in the group 3. The lowest number of TNK- and NK-cells was found in the group of patients who received radiosurgical treatment as monotherapy, which correlated with the highest incidence of high-risk HPV persistence after treatment in this group. Conclusions. In patients with various grade CIN, the use of an immunomodulatory drug with antiviral activity in combination with radiosurgical intervention promotes early epithelialization of the cervix and elimination of high-risk HPV, which is confirmed by significant changes in the lymphocyte subpopulations which provide antiviral immunity.Liana S. MkrtchianLiudmila Iu. GrivtsovaValentina I. KiselevaAnna M. AleshinaLiudmila I. KrikunovaIP Berlin A.V. articlecervical cancercervical dysplasiacervical intraepithelial neoplasiacarcinoma in situhigh-risk human papillomavirusradio wave cone biopsyimmunotherapyGynecology and obstetricsRG1-991RUГинекология, Vol 23, Iss 1, Pp 62-67 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
RU |
| topic |
cervical cancer cervical dysplasia cervical intraepithelial neoplasia carcinoma in situ high-risk human papillomavirus radio wave cone biopsy immunotherapy Gynecology and obstetrics RG1-991 |
| spellingShingle |
cervical cancer cervical dysplasia cervical intraepithelial neoplasia carcinoma in situ high-risk human papillomavirus radio wave cone biopsy immunotherapy Gynecology and obstetrics RG1-991 Liana S. Mkrtchian Liudmila Iu. Grivtsova Valentina I. Kiseleva Anna M. Aleshina Liudmila I. Krikunova Comprehensive treatment of cervical intraepithelial neoplasia |
| description |
Aim. To study the effectiveness of the use of Neovir (sodium oxodihydroacridinyl acetates) as immunomodulatory and antiviral drug in the comprehensive treatment of various grade cervical intraepithelial neoplasia (CIN). Study design: prospective comparative study.
Materials and methods. The study included 60 patients (mean age 34.78.2 years) with morphologically verified various grade CIN, who were received comprehensive treatment, including the use of Neovir (sodium oxodihydroacridinyl acetate) as the drug with immunomodulatory and antiviral activity, 250 mg/2 ml intramuscularly every 48 hours, 10 injections before (group 1) or after (group 2) multi-stage radiosurgical diagnostic and treatment procedure or only a similar surgical intervention (group 3). All patients underwent complete clinical, morphological and laboratory examination with monitoring for the presence of high-risk human papillomavirus (HPV) in the cervical scraping and the dynamics of peripheral blood lymphocyte subpopulations.
Results. Dynamic follow-up showed that in a month after surgery, patients who were treated with radiosurgical resection as monotherapy (group 3) had the lowest rate of complete epithelialization of the cervical stump 30.0% vs 55.0 and 65,0% in the group 1 and group 2 respectively. In this group, the proportion of patients with persistent viral infection was 1.52 times higher than in the groups where an antiviral drug was used in combination with radiosurgical intervention 35.7% vs 17.6 and 22.2% in the group 1 and group2, respectively. In 6 months, elimination of high-risk HPV in groups with comprehensive treatment reached 94.5 in the group 1 and 94.1% in the group 2 (p0.05) vs 78.6% in the group 3. The lowest number of TNK- and NK-cells was found in the group of patients who received radiosurgical treatment as monotherapy, which correlated with the highest incidence of high-risk HPV persistence after treatment in this group.
Conclusions. In patients with various grade CIN, the use of an immunomodulatory drug with antiviral activity in combination with radiosurgical intervention promotes early epithelialization of the cervix and elimination of high-risk HPV, which is confirmed by significant changes in the lymphocyte subpopulations which provide antiviral immunity. |
| format |
article |
| author |
Liana S. Mkrtchian Liudmila Iu. Grivtsova Valentina I. Kiseleva Anna M. Aleshina Liudmila I. Krikunova |
| author_facet |
Liana S. Mkrtchian Liudmila Iu. Grivtsova Valentina I. Kiseleva Anna M. Aleshina Liudmila I. Krikunova |
| author_sort |
Liana S. Mkrtchian |
| title |
Comprehensive treatment of cervical intraepithelial neoplasia |
| title_short |
Comprehensive treatment of cervical intraepithelial neoplasia |
| title_full |
Comprehensive treatment of cervical intraepithelial neoplasia |
| title_fullStr |
Comprehensive treatment of cervical intraepithelial neoplasia |
| title_full_unstemmed |
Comprehensive treatment of cervical intraepithelial neoplasia |
| title_sort |
comprehensive treatment of cervical intraepithelial neoplasia |
| publisher |
IP Berlin A.V. |
| publishDate |
2021 |
| url |
https://doaj.org/article/591f8831abca4f2fbc9770db0aabf9bf |
| work_keys_str_mv |
AT lianasmkrtchian comprehensivetreatmentofcervicalintraepithelialneoplasia AT liudmilaiugrivtsova comprehensivetreatmentofcervicalintraepithelialneoplasia AT valentinaikiseleva comprehensivetreatmentofcervicalintraepithelialneoplasia AT annamaleshina comprehensivetreatmentofcervicalintraepithelialneoplasia AT liudmilaikrikunova comprehensivetreatmentofcervicalintraepithelialneoplasia |
| _version_ |
1718376737705820160 |