A prognostic value of CD45RA+, CD45RO+, CCL20+ and CCR6+ expressing cells as ‘immunoscore’ to predict cervical cancer induced by HPV
Abstract The interplay between cervical cancer (CC) and immune cells, mainly intratumoral lymphocytes, has a pivotal role in carcinogenesis. In this context, we evaluated the distribution of CD45RA+ and CD45RO+ cells as well as CCR6+ and CCL20+ cells in intraepithelial (IE) and marginal stroma (MS)...
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Nature Portfolio
2021
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oai:doaj.org-article:592464b0cbfb4e909886bfcf22d5c51f2021-12-02T18:27:48ZA prognostic value of CD45RA+, CD45RO+, CCL20+ and CCR6+ expressing cells as ‘immunoscore’ to predict cervical cancer induced by HPV10.1038/s41598-021-88248-x2045-2322https://doaj.org/article/592464b0cbfb4e909886bfcf22d5c51f2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88248-xhttps://doaj.org/toc/2045-2322Abstract The interplay between cervical cancer (CC) and immune cells, mainly intratumoral lymphocytes, has a pivotal role in carcinogenesis. In this context, we evaluated the distribution of CD45RA+ and CD45RO+ cells as well as CCR6+ and CCL20+ cells in intraepithelial (IE) and marginal stroma (MS) areas from cervical intraepithelial neoplasia (CIN) I–III, and CC as ‘immunoscore’ for HPV-induced CC outcome. We observed increased CD45RA+ and CD45RO+ cells distribution in IE and MS areas in the CC group compared to CIN groups and healthy volunteers. Interestingly, there is a remarkable reduction of CCL20+ expressing cells distribution according to lesion severity. The CC group had a significant decrease in CCL20+ and CCR6+-expressing cells distribution in both IE and MS areas compared to all groups. Using the ‘immunoscore’ model, we observed an increased number of women presenting high CD45RA+/CD45RO+ and low CCL20+/CCR6+ ‘immunoscore’ in the CC group. Our results suggested a pattern in cervical inflammatory process with increasing CD45RA+/CD45RO+, and decreasing CCL20+/CCR6+ expression in accordance with CIN severity. Taken together, these markers could be evaluated as ‘immunoscore’ predictors to CC response. A more comprehensive analysis of longitudinal studies should be conducted to associate CD45RA+/CD45RO+ and CCL20+/CCR6+ ‘immunoscore’ to CC progression and validate its value as a prognosis method.Ana Teresa G. FernandesMaria Odete O. CarvalhoElyzabeth Avvad-PortariNatália P. RochaFabio RussomanoEric Henrique RomaMaria da Gloria Bonecini-AlmeidaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021) |
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Medicine R Science Q Ana Teresa G. Fernandes Maria Odete O. Carvalho Elyzabeth Avvad-Portari Natália P. Rocha Fabio Russomano Eric Henrique Roma Maria da Gloria Bonecini-Almeida A prognostic value of CD45RA+, CD45RO+, CCL20+ and CCR6+ expressing cells as ‘immunoscore’ to predict cervical cancer induced by HPV |
| description |
Abstract The interplay between cervical cancer (CC) and immune cells, mainly intratumoral lymphocytes, has a pivotal role in carcinogenesis. In this context, we evaluated the distribution of CD45RA+ and CD45RO+ cells as well as CCR6+ and CCL20+ cells in intraepithelial (IE) and marginal stroma (MS) areas from cervical intraepithelial neoplasia (CIN) I–III, and CC as ‘immunoscore’ for HPV-induced CC outcome. We observed increased CD45RA+ and CD45RO+ cells distribution in IE and MS areas in the CC group compared to CIN groups and healthy volunteers. Interestingly, there is a remarkable reduction of CCL20+ expressing cells distribution according to lesion severity. The CC group had a significant decrease in CCL20+ and CCR6+-expressing cells distribution in both IE and MS areas compared to all groups. Using the ‘immunoscore’ model, we observed an increased number of women presenting high CD45RA+/CD45RO+ and low CCL20+/CCR6+ ‘immunoscore’ in the CC group. Our results suggested a pattern in cervical inflammatory process with increasing CD45RA+/CD45RO+, and decreasing CCL20+/CCR6+ expression in accordance with CIN severity. Taken together, these markers could be evaluated as ‘immunoscore’ predictors to CC response. A more comprehensive analysis of longitudinal studies should be conducted to associate CD45RA+/CD45RO+ and CCL20+/CCR6+ ‘immunoscore’ to CC progression and validate its value as a prognosis method. |
| format |
article |
| author |
Ana Teresa G. Fernandes Maria Odete O. Carvalho Elyzabeth Avvad-Portari Natália P. Rocha Fabio Russomano Eric Henrique Roma Maria da Gloria Bonecini-Almeida |
| author_facet |
Ana Teresa G. Fernandes Maria Odete O. Carvalho Elyzabeth Avvad-Portari Natália P. Rocha Fabio Russomano Eric Henrique Roma Maria da Gloria Bonecini-Almeida |
| author_sort |
Ana Teresa G. Fernandes |
| title |
A prognostic value of CD45RA+, CD45RO+, CCL20+ and CCR6+ expressing cells as ‘immunoscore’ to predict cervical cancer induced by HPV |
| title_short |
A prognostic value of CD45RA+, CD45RO+, CCL20+ and CCR6+ expressing cells as ‘immunoscore’ to predict cervical cancer induced by HPV |
| title_full |
A prognostic value of CD45RA+, CD45RO+, CCL20+ and CCR6+ expressing cells as ‘immunoscore’ to predict cervical cancer induced by HPV |
| title_fullStr |
A prognostic value of CD45RA+, CD45RO+, CCL20+ and CCR6+ expressing cells as ‘immunoscore’ to predict cervical cancer induced by HPV |
| title_full_unstemmed |
A prognostic value of CD45RA+, CD45RO+, CCL20+ and CCR6+ expressing cells as ‘immunoscore’ to predict cervical cancer induced by HPV |
| title_sort |
prognostic value of cd45ra+, cd45ro+, ccl20+ and ccr6+ expressing cells as ‘immunoscore’ to predict cervical cancer induced by hpv |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/592464b0cbfb4e909886bfcf22d5c51f |
| work_keys_str_mv |
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| _version_ |
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