Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure

Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure

The pathophysiological role of dopamine D1 receptor (D1R) in chronic heart failure remains elusive. Here the authors show that D1R-expressing cardiomyocytes appear in chronic heart failure and play a pivotal role in triggering lethal ventricular arrhythmias.

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Auteurs principaux: Toshihiro Yamaguchi, Tomokazu S. Sumida, Seitaro Nomura, Masahiro Satoh, Tomoaki Higo, Masamichi Ito, Toshiyuki Ko, Kanna Fujita, Mary E. Sweet, Atsushi Sanbe, Kenji Yoshimi, Ichiro Manabe, Toshikuni Sasaoka, Matthew R. G. Taylor, Haruhiro Toko, Eiki Takimoto, Atsuhiko T. Naito, Issei Komuro
Format: article
Langue:EN
Publié: Nature Portfolio 2020
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/59249ab8e1b144e4814231c3afc24f46
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Résumé:The pathophysiological role of dopamine D1 receptor (D1R) in chronic heart failure remains elusive. Here the authors show that D1R-expressing cardiomyocytes appear in chronic heart failure and play a pivotal role in triggering lethal ventricular arrhythmias.

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