Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure

The pathophysiological role of dopamine D1 receptor (D1R) in chronic heart failure remains elusive. Here the authors show that D1R-expressing cardiomyocytes appear in chronic heart failure and play a pivotal role in triggering lethal ventricular arrhythmias.

Guardado en:

Detalles Bibliográficos
Autores principales:	Toshihiro Yamaguchi, Tomokazu S. Sumida, Seitaro Nomura, Masahiro Satoh, Tomoaki Higo, Masamichi Ito, Toshiyuki Ko, Kanna Fujita, Mary E. Sweet, Atsushi Sanbe, Kenji Yoshimi, Ichiro Manabe, Toshikuni Sasaoka, Matthew R. G. Taylor, Haruhiro Toko, Eiki Takimoto, Atsuhiko T. Naito, Issei Komuro
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/59249ab8e1b144e4814231c3afc24f46
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:59249ab8e1b144e4814231c3afc24f46
record_format	dspace
spelling	oai:doaj.org-article:59249ab8e1b144e4814231c3afc24f462021-12-02T19:09:20ZCardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure10.1038/s41467-020-18128-x2041-1723https://doaj.org/article/59249ab8e1b144e4814231c3afc24f462020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18128-xhttps://doaj.org/toc/2041-1723The pathophysiological role of dopamine D1 receptor (D1R) in chronic heart failure remains elusive. Here the authors show that D1R-expressing cardiomyocytes appear in chronic heart failure and play a pivotal role in triggering lethal ventricular arrhythmias.Toshihiro YamaguchiTomokazu S. SumidaSeitaro NomuraMasahiro SatohTomoaki HigoMasamichi ItoToshiyuki KoKanna FujitaMary E. SweetAtsushi SanbeKenji YoshimiIchiro ManabeToshikuni SasaokaMatthew R. G. TaylorHaruhiro TokoEiki TakimotoAtsuhiko T. NaitoIssei KomuroNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Toshihiro Yamaguchi Tomokazu S. Sumida Seitaro Nomura Masahiro Satoh Tomoaki Higo Masamichi Ito Toshiyuki Ko Kanna Fujita Mary E. Sweet Atsushi Sanbe Kenji Yoshimi Ichiro Manabe Toshikuni Sasaoka Matthew R. G. Taylor Haruhiro Toko Eiki Takimoto Atsuhiko T. Naito Issei Komuro Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure
description	The pathophysiological role of dopamine D1 receptor (D1R) in chronic heart failure remains elusive. Here the authors show that D1R-expressing cardiomyocytes appear in chronic heart failure and play a pivotal role in triggering lethal ventricular arrhythmias.
format	article
author	Toshihiro Yamaguchi Tomokazu S. Sumida Seitaro Nomura Masahiro Satoh Tomoaki Higo Masamichi Ito Toshiyuki Ko Kanna Fujita Mary E. Sweet Atsushi Sanbe Kenji Yoshimi Ichiro Manabe Toshikuni Sasaoka Matthew R. G. Taylor Haruhiro Toko Eiki Takimoto Atsuhiko T. Naito Issei Komuro
author_facet	Toshihiro Yamaguchi Tomokazu S. Sumida Seitaro Nomura Masahiro Satoh Tomoaki Higo Masamichi Ito Toshiyuki Ko Kanna Fujita Mary E. Sweet Atsushi Sanbe Kenji Yoshimi Ichiro Manabe Toshikuni Sasaoka Matthew R. G. Taylor Haruhiro Toko Eiki Takimoto Atsuhiko T. Naito Issei Komuro
author_sort	Toshihiro Yamaguchi
title	Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure
title_short	Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure
title_full	Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure
title_fullStr	Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure
title_full_unstemmed	Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure
title_sort	cardiac dopamine d1 receptor triggers ventricular arrhythmia in chronic heart failure
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/59249ab8e1b144e4814231c3afc24f46
work_keys_str_mv	AT toshihiroyamaguchi cardiacdopamined1receptortriggersventriculararrhythmiainchronicheartfailure AT tomokazussumida cardiacdopamined1receptortriggersventriculararrhythmiainchronicheartfailure AT seitaronomura cardiacdopamined1receptortriggersventriculararrhythmiainchronicheartfailure AT masahirosatoh cardiacdopamined1receptortriggersventriculararrhythmiainchronicheartfailure AT tomoakihigo cardiacdopamined1receptortriggersventriculararrhythmiainchronicheartfailure AT masamichiito cardiacdopamined1receptortriggersventriculararrhythmiainchronicheartfailure AT toshiyukiko cardiacdopamined1receptortriggersventriculararrhythmiainchronicheartfailure AT kannafujita cardiacdopamined1receptortriggersventriculararrhythmiainchronicheartfailure AT maryesweet cardiacdopamined1receptortriggersventriculararrhythmiainchronicheartfailure AT atsushisanbe cardiacdopamined1receptortriggersventriculararrhythmiainchronicheartfailure AT kenjiyoshimi cardiacdopamined1receptortriggersventriculararrhythmiainchronicheartfailure AT ichiromanabe cardiacdopamined1receptortriggersventriculararrhythmiainchronicheartfailure AT toshikunisasaoka cardiacdopamined1receptortriggersventriculararrhythmiainchronicheartfailure AT matthewrgtaylor cardiacdopamined1receptortriggersventriculararrhythmiainchronicheartfailure AT haruhirotoko cardiacdopamined1receptortriggersventriculararrhythmiainchronicheartfailure AT eikitakimoto cardiacdopamined1receptortriggersventriculararrhythmiainchronicheartfailure AT atsuhikotnaito cardiacdopamined1receptortriggersventriculararrhythmiainchronicheartfailure AT isseikomuro cardiacdopamined1receptortriggersventriculararrhythmiainchronicheartfailure
_version_	1718377150901387264

Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure

Ejemplares similares