Rate of Heart Failure Following Atrial Fibrillation According to Presence of Family History of Dilated Cardiomyopathy or Heart Failure: A Nationwide Study

Background It is poorly understood why some patients with atrial fibrillation develop heart failure (HF) and others do not. We examined the rate of developing HF in patients with atrial fibrillation with and without first‐degree family members with HF or dilated cardiomyopathy (DCM). Methods and Res...

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Autores principales:	Magnus N. Ebbesen, Maria D’Souza, Charlotte Andersson, Jawad H. Butt, Christian Madelaire, Tor Biering‐Sorensen, Morten Lock‐Hansen, Soren Lund Kristensen, Gunnar Gislason, Lars Kober, Christian Torp‐Pedersen, Morten Schou
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	atrial fibrillation heart failure family history family study Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/5929e3187cb54708b68f37e5a36520d8
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spelling	oai:doaj.org-article:5929e3187cb54708b68f37e5a36520d82021-11-16T10:22:43ZRate of Heart Failure Following Atrial Fibrillation According to Presence of Family History of Dilated Cardiomyopathy or Heart Failure: A Nationwide Study10.1161/JAHA.120.0212862047-9980https://doaj.org/article/5929e3187cb54708b68f37e5a36520d82021-11-01T00:00:00Zhttps://www.ahajournals.org/doi/10.1161/JAHA.120.021286https://doaj.org/toc/2047-9980Background It is poorly understood why some patients with atrial fibrillation develop heart failure (HF) and others do not. We examined the rate of developing HF in patients with atrial fibrillation with and without first‐degree family members with HF or dilated cardiomyopathy (DCM). Methods and Results Using Danish nationwide registries, patients born after 1942 diagnosed with atrial fibrillation in the period 2005 to 2015 were identified and followed for up to 5 years. Patients with pre‐existing HF, DCM, and/or ischemic heart disease diagnoses were excluded. Exposure was defined as a first‐degree relative with HF or DCM. The rate of developing the composite end point of HF or death, and the components, was estimated with multivariable Cox proportional hazard regression models. We included 10 605 patients. A total of 17% had a family member with DCM/HF. Having a family member with HF/DCM was associated with an increased 5‐year risk of the composite of HF/death (cumulative incidence, 9.2% [95% CI, 7.8–10.7] versus 5.6% [95% CI, 5.0–6.1]; adjusted hazard ratio [HR] 1.36 [95% CI, 1.13–1.64]). (HF 8.4% [95% CI, 7.0–9.8] versus 4.5% [95% CI, 4.1–5.0]); (adjusted HR, 1.49 [95% CI, 1.22–1.82]). However, familial HF/DCM was not significantly associated with an increased 5‐year risk and rate of death (0.8% [95% CI, 0.4–1.2] versus 1.1% [95% CI, 0.8–1.3]); (adjusted HR, 0.80 [95% CI, 0.46–1.39]). Conclusions In patients with incident atrial fibrillation without prior ischemic heart disease or HF diagnoses, 1 of 6 had a first‐degree relative with HF, and having such a family history of HF/DCM was associated with an 87% increase in 5‐year incidence of HF compared with those without.Magnus N. EbbesenMaria D’SouzaCharlotte AnderssonJawad H. ButtChristian MadelaireTor Biering‐SorensenMorten Lock‐HansenSoren Lund KristensenGunnar GislasonLars KoberChristian Torp‐PedersenMorten SchouWileyarticleatrial fibrillation heart failurefamily historyfamily studyDiseases of the circulatory (Cardiovascular) systemRC666-701ENJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 22 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	atrial fibrillation heart failure family history family study Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	atrial fibrillation heart failure family history family study Diseases of the circulatory (Cardiovascular) system RC666-701 Magnus N. Ebbesen Maria D’Souza Charlotte Andersson Jawad H. Butt Christian Madelaire Tor Biering‐Sorensen Morten Lock‐Hansen Soren Lund Kristensen Gunnar Gislason Lars Kober Christian Torp‐Pedersen Morten Schou Rate of Heart Failure Following Atrial Fibrillation According to Presence of Family History of Dilated Cardiomyopathy or Heart Failure: A Nationwide Study
description	Background It is poorly understood why some patients with atrial fibrillation develop heart failure (HF) and others do not. We examined the rate of developing HF in patients with atrial fibrillation with and without first‐degree family members with HF or dilated cardiomyopathy (DCM). Methods and Results Using Danish nationwide registries, patients born after 1942 diagnosed with atrial fibrillation in the period 2005 to 2015 were identified and followed for up to 5 years. Patients with pre‐existing HF, DCM, and/or ischemic heart disease diagnoses were excluded. Exposure was defined as a first‐degree relative with HF or DCM. The rate of developing the composite end point of HF or death, and the components, was estimated with multivariable Cox proportional hazard regression models. We included 10 605 patients. A total of 17% had a family member with DCM/HF. Having a family member with HF/DCM was associated with an increased 5‐year risk of the composite of HF/death (cumulative incidence, 9.2% [95% CI, 7.8–10.7] versus 5.6% [95% CI, 5.0–6.1]; adjusted hazard ratio [HR] 1.36 [95% CI, 1.13–1.64]). (HF 8.4% [95% CI, 7.0–9.8] versus 4.5% [95% CI, 4.1–5.0]); (adjusted HR, 1.49 [95% CI, 1.22–1.82]). However, familial HF/DCM was not significantly associated with an increased 5‐year risk and rate of death (0.8% [95% CI, 0.4–1.2] versus 1.1% [95% CI, 0.8–1.3]); (adjusted HR, 0.80 [95% CI, 0.46–1.39]). Conclusions In patients with incident atrial fibrillation without prior ischemic heart disease or HF diagnoses, 1 of 6 had a first‐degree relative with HF, and having such a family history of HF/DCM was associated with an 87% increase in 5‐year incidence of HF compared with those without.
format	article
author	Magnus N. Ebbesen Maria D’Souza Charlotte Andersson Jawad H. Butt Christian Madelaire Tor Biering‐Sorensen Morten Lock‐Hansen Soren Lund Kristensen Gunnar Gislason Lars Kober Christian Torp‐Pedersen Morten Schou
author_facet	Magnus N. Ebbesen Maria D’Souza Charlotte Andersson Jawad H. Butt Christian Madelaire Tor Biering‐Sorensen Morten Lock‐Hansen Soren Lund Kristensen Gunnar Gislason Lars Kober Christian Torp‐Pedersen Morten Schou
author_sort	Magnus N. Ebbesen
title	Rate of Heart Failure Following Atrial Fibrillation According to Presence of Family History of Dilated Cardiomyopathy or Heart Failure: A Nationwide Study
title_short	Rate of Heart Failure Following Atrial Fibrillation According to Presence of Family History of Dilated Cardiomyopathy or Heart Failure: A Nationwide Study
title_full	Rate of Heart Failure Following Atrial Fibrillation According to Presence of Family History of Dilated Cardiomyopathy or Heart Failure: A Nationwide Study
title_fullStr	Rate of Heart Failure Following Atrial Fibrillation According to Presence of Family History of Dilated Cardiomyopathy or Heart Failure: A Nationwide Study
title_full_unstemmed	Rate of Heart Failure Following Atrial Fibrillation According to Presence of Family History of Dilated Cardiomyopathy or Heart Failure: A Nationwide Study
title_sort	rate of heart failure following atrial fibrillation according to presence of family history of dilated cardiomyopathy or heart failure: a nationwide study
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/5929e3187cb54708b68f37e5a36520d8
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Rate of Heart Failure Following Atrial Fibrillation According to Presence of Family History of Dilated Cardiomyopathy or Heart Failure: A Nationwide Study

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