Mast cell activation in the acupoint is important for the electroacupuncture effect against pituitrin-induced bradycardia in rabbits

Abstract This research was conducted to verify the structural and functional characteristics of mast cells in the electroacupuncture (EA) effects on bradycardia. First, we examined the mast cell density at PC 6, adjacent acupoint LU 7, and a non-acupoint. We tested the effects of EA at PC 6 on heart...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Haining Zhu, Xuezhi Wang, Meng Huang, Yi Jing, Di Zhang, Guanghong Ding
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/592b39be53d949d49fc8ea4c2d3c036b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:592b39be53d949d49fc8ea4c2d3c036b
record_format	dspace
spelling	oai:doaj.org-article:592b39be53d949d49fc8ea4c2d3c036b2021-12-02T11:52:44ZMast cell activation in the acupoint is important for the electroacupuncture effect against pituitrin-induced bradycardia in rabbits10.1038/s41598-017-08855-52045-2322https://doaj.org/article/592b39be53d949d49fc8ea4c2d3c036b2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08855-5https://doaj.org/toc/2045-2322Abstract This research was conducted to verify the structural and functional characteristics of mast cells in the electroacupuncture (EA) effects on bradycardia. First, we examined the mast cell density at PC 6, adjacent acupoint LU 7, and a non-acupoint. We tested the effects of EA at PC 6 on heart rate (HR) and blood pressure (BP) in rabbits with pituitrin-induced bradycardia. We also injected sodium cromolyn (Cro), a mast cell membrane stabilizer, at PC 6 30 min before EA to investigate if it affected the EA effects. The results showed that in both PC 6 and LU 7, the mast cell densities were higher than in the non-acupoint (P < 0.05). EA could induce mast cell degranulation at PC 6, which could be suppressed by sodium cromolyn (P < 0.05). EA improved HR, though the change was relatively small in the initial stage with a significant change at 35 min after modelling (P < 0.05). BP significantly improved at 10 min after the onset of pituitrin-induced bradycardia (P < 0.05). The EA effects on both HR and BP were suppressed by sodium cromolyn (P < 0.05). Therefore, we concluded that mast cells in the acupoint are important for the EA effects against pituitrin-induced bradycardia in rabbits.Haining ZhuXuezhi WangMeng HuangYi JingDi ZhangGuanghong DingNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Haining Zhu Xuezhi Wang Meng Huang Yi Jing Di Zhang Guanghong Ding Mast cell activation in the acupoint is important for the electroacupuncture effect against pituitrin-induced bradycardia in rabbits
description	Abstract This research was conducted to verify the structural and functional characteristics of mast cells in the electroacupuncture (EA) effects on bradycardia. First, we examined the mast cell density at PC 6, adjacent acupoint LU 7, and a non-acupoint. We tested the effects of EA at PC 6 on heart rate (HR) and blood pressure (BP) in rabbits with pituitrin-induced bradycardia. We also injected sodium cromolyn (Cro), a mast cell membrane stabilizer, at PC 6 30 min before EA to investigate if it affected the EA effects. The results showed that in both PC 6 and LU 7, the mast cell densities were higher than in the non-acupoint (P < 0.05). EA could induce mast cell degranulation at PC 6, which could be suppressed by sodium cromolyn (P < 0.05). EA improved HR, though the change was relatively small in the initial stage with a significant change at 35 min after modelling (P < 0.05). BP significantly improved at 10 min after the onset of pituitrin-induced bradycardia (P < 0.05). The EA effects on both HR and BP were suppressed by sodium cromolyn (P < 0.05). Therefore, we concluded that mast cells in the acupoint are important for the EA effects against pituitrin-induced bradycardia in rabbits.
format	article
author	Haining Zhu Xuezhi Wang Meng Huang Yi Jing Di Zhang Guanghong Ding
author_facet	Haining Zhu Xuezhi Wang Meng Huang Yi Jing Di Zhang Guanghong Ding
author_sort	Haining Zhu
title	Mast cell activation in the acupoint is important for the electroacupuncture effect against pituitrin-induced bradycardia in rabbits
title_short	Mast cell activation in the acupoint is important for the electroacupuncture effect against pituitrin-induced bradycardia in rabbits
title_full	Mast cell activation in the acupoint is important for the electroacupuncture effect against pituitrin-induced bradycardia in rabbits
title_fullStr	Mast cell activation in the acupoint is important for the electroacupuncture effect against pituitrin-induced bradycardia in rabbits
title_full_unstemmed	Mast cell activation in the acupoint is important for the electroacupuncture effect against pituitrin-induced bradycardia in rabbits
title_sort	mast cell activation in the acupoint is important for the electroacupuncture effect against pituitrin-induced bradycardia in rabbits
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/592b39be53d949d49fc8ea4c2d3c036b
work_keys_str_mv	AT hainingzhu mastcellactivationintheacupointisimportantfortheelectroacupunctureeffectagainstpituitrininducedbradycardiainrabbits AT xuezhiwang mastcellactivationintheacupointisimportantfortheelectroacupunctureeffectagainstpituitrininducedbradycardiainrabbits AT menghuang mastcellactivationintheacupointisimportantfortheelectroacupunctureeffectagainstpituitrininducedbradycardiainrabbits AT yijing mastcellactivationintheacupointisimportantfortheelectroacupunctureeffectagainstpituitrininducedbradycardiainrabbits AT dizhang mastcellactivationintheacupointisimportantfortheelectroacupunctureeffectagainstpituitrininducedbradycardiainrabbits AT guanghongding mastcellactivationintheacupointisimportantfortheelectroacupunctureeffectagainstpituitrininducedbradycardiainrabbits
_version_	1718394923626004480

Mast cell activation in the acupoint is important for the electroacupuncture effect against pituitrin-induced bradycardia in rabbits

Ejemplares similares