Integrative genomic study of Chinese clear cell renal cell carcinoma reveals features associated with thrombus

Integrative genomic study of Chinese clear cell renal cell carcinoma reveals features associated with thrombus

The genomic heterogeneity of clear cell renal cell carcinoma (ccRCC) across populations is poorly understood. Here, the authors analyse a cohort of Chinese ccRCC cases revealing a mutational signature associated with aristolochic acid exposure, and higher mutational burden and enrichment for BAP1 an...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Xiang-Ming Wang, Yang Lu, Yi-Meng Song, Jun Dong, Ruo-Yan Li, Guo-Liang Wang, Xu Wang, Shu-Dong Zhang, Zhou-Huan Dong, Min Lu, Shi-Yu Wang, Li-Yuan Ge, Guang-Da Luo, Run-Zhuo Ma, Steve George Rozen, Fan Bai, Di Wu, Lu-Lin Ma
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/592ba28dde4d4871b321ea39f7b3c91e
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:592ba28dde4d4871b321ea39f7b3c91e
record_format dspace
spelling oai:doaj.org-article:592ba28dde4d4871b321ea39f7b3c91e2021-12-02T17:32:59ZIntegrative genomic study of Chinese clear cell renal cell carcinoma reveals features associated with thrombus10.1038/s41467-020-14601-92041-1723https://doaj.org/article/592ba28dde4d4871b321ea39f7b3c91e2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14601-9https://doaj.org/toc/2041-1723The genomic heterogeneity of clear cell renal cell carcinoma (ccRCC) across populations is poorly understood. Here, the authors analyse a cohort of Chinese ccRCC cases revealing a mutational signature associated with aristolochic acid exposure, and higher mutational burden and enrichment for BAP1 and SETD2 mutations in ccRCC cases associated with tumor thrombus.Xiang-Ming WangYang LuYi-Meng SongJun DongRuo-Yan LiGuo-Liang WangXu WangShu-Dong ZhangZhou-Huan DongMin LuShi-Yu WangLi-Yuan GeGuang-Da LuoRun-Zhuo MaSteve George RozenFan BaiDi WuLu-Lin MaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xiang-Ming Wang
Yang Lu
Yi-Meng Song
Jun Dong
Ruo-Yan Li
Guo-Liang Wang
Xu Wang
Shu-Dong Zhang
Zhou-Huan Dong
Min Lu
Shi-Yu Wang
Li-Yuan Ge
Guang-Da Luo
Run-Zhuo Ma
Steve George Rozen
Fan Bai
Di Wu
Lu-Lin Ma
Integrative genomic study of Chinese clear cell renal cell carcinoma reveals features associated with thrombus
description The genomic heterogeneity of clear cell renal cell carcinoma (ccRCC) across populations is poorly understood. Here, the authors analyse a cohort of Chinese ccRCC cases revealing a mutational signature associated with aristolochic acid exposure, and higher mutational burden and enrichment for BAP1 and SETD2 mutations in ccRCC cases associated with tumor thrombus.
format article
author Xiang-Ming Wang
Yang Lu
Yi-Meng Song
Jun Dong
Ruo-Yan Li
Guo-Liang Wang
Xu Wang
Shu-Dong Zhang
Zhou-Huan Dong
Min Lu
Shi-Yu Wang
Li-Yuan Ge
Guang-Da Luo
Run-Zhuo Ma
Steve George Rozen
Fan Bai
Di Wu
Lu-Lin Ma
author_facet Xiang-Ming Wang
Yang Lu
Yi-Meng Song
Jun Dong
Ruo-Yan Li
Guo-Liang Wang
Xu Wang
Shu-Dong Zhang
Zhou-Huan Dong
Min Lu
Shi-Yu Wang
Li-Yuan Ge
Guang-Da Luo
Run-Zhuo Ma
Steve George Rozen
Fan Bai
Di Wu
Lu-Lin Ma
author_sort Xiang-Ming Wang
title Integrative genomic study of Chinese clear cell renal cell carcinoma reveals features associated with thrombus
title_short Integrative genomic study of Chinese clear cell renal cell carcinoma reveals features associated with thrombus
title_full Integrative genomic study of Chinese clear cell renal cell carcinoma reveals features associated with thrombus
title_fullStr Integrative genomic study of Chinese clear cell renal cell carcinoma reveals features associated with thrombus
title_full_unstemmed Integrative genomic study of Chinese clear cell renal cell carcinoma reveals features associated with thrombus
title_sort integrative genomic study of chinese clear cell renal cell carcinoma reveals features associated with thrombus
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/592ba28dde4d4871b321ea39f7b3c91e
work_keys_str_mv AT xiangmingwang integrativegenomicstudyofchineseclearcellrenalcellcarcinomarevealsfeaturesassociatedwiththrombus
AT yanglu integrativegenomicstudyofchineseclearcellrenalcellcarcinomarevealsfeaturesassociatedwiththrombus
AT yimengsong integrativegenomicstudyofchineseclearcellrenalcellcarcinomarevealsfeaturesassociatedwiththrombus
AT jundong integrativegenomicstudyofchineseclearcellrenalcellcarcinomarevealsfeaturesassociatedwiththrombus
AT ruoyanli integrativegenomicstudyofchineseclearcellrenalcellcarcinomarevealsfeaturesassociatedwiththrombus
AT guoliangwang integrativegenomicstudyofchineseclearcellrenalcellcarcinomarevealsfeaturesassociatedwiththrombus
AT xuwang integrativegenomicstudyofchineseclearcellrenalcellcarcinomarevealsfeaturesassociatedwiththrombus
AT shudongzhang integrativegenomicstudyofchineseclearcellrenalcellcarcinomarevealsfeaturesassociatedwiththrombus
AT zhouhuandong integrativegenomicstudyofchineseclearcellrenalcellcarcinomarevealsfeaturesassociatedwiththrombus
AT minlu integrativegenomicstudyofchineseclearcellrenalcellcarcinomarevealsfeaturesassociatedwiththrombus
AT shiyuwang integrativegenomicstudyofchineseclearcellrenalcellcarcinomarevealsfeaturesassociatedwiththrombus
AT liyuange integrativegenomicstudyofchineseclearcellrenalcellcarcinomarevealsfeaturesassociatedwiththrombus
AT guangdaluo integrativegenomicstudyofchineseclearcellrenalcellcarcinomarevealsfeaturesassociatedwiththrombus
AT runzhuoma integrativegenomicstudyofchineseclearcellrenalcellcarcinomarevealsfeaturesassociatedwiththrombus
AT stevegeorgerozen integrativegenomicstudyofchineseclearcellrenalcellcarcinomarevealsfeaturesassociatedwiththrombus
AT fanbai integrativegenomicstudyofchineseclearcellrenalcellcarcinomarevealsfeaturesassociatedwiththrombus
AT diwu integrativegenomicstudyofchineseclearcellrenalcellcarcinomarevealsfeaturesassociatedwiththrombus
AT lulinma integrativegenomicstudyofchineseclearcellrenalcellcarcinomarevealsfeaturesassociatedwiththrombus
_version_ 1718380121105104896

Ejemplares similares