Amyloid beta inhibits olfactory bulb activity and the ability to smell.

Early olfactory dysfunction has been consistently reported in both Alzheimer's disease (AD) and in transgenic mice that reproduce some features of this disease. In AD transgenic mice, alteration in olfaction has been associated with increased levels of soluble amyloid beta protein (Aβ) as well...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Reynaldo Alvarado-Martínez, Karla Salgado-Puga, Fernando Peña-Ortega
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/592e942d23e34e21a80198d0c9f561cf
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:592e942d23e34e21a80198d0c9f561cf
record_format	dspace
spelling	oai:doaj.org-article:592e942d23e34e21a80198d0c9f561cf2021-11-18T08:53:37ZAmyloid beta inhibits olfactory bulb activity and the ability to smell.1932-620310.1371/journal.pone.0075745https://doaj.org/article/592e942d23e34e21a80198d0c9f561cf2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24086624/?tool=EBIhttps://doaj.org/toc/1932-6203Early olfactory dysfunction has been consistently reported in both Alzheimer's disease (AD) and in transgenic mice that reproduce some features of this disease. In AD transgenic mice, alteration in olfaction has been associated with increased levels of soluble amyloid beta protein (Aβ) as well as with alterations in the oscillatory network activity recorded in the olfactory bulb (OB) and in the piriform cortex. However, since AD is a multifactorial disease and transgenic mice suffer a variety of adaptive changes, it is still unknown if soluble Aβ, by itself, is responsible for OB dysfunction both at electrophysiological and behavioral levels. Thus, here we tested whether or not Aβ directly affects OB network activity in vitro in slices obtained from mice and rats and if it affects olfactory ability in these rodents. Our results show that Aβ decreases, in a concentration- and time-dependent manner, the network activity of OB slices at clinically relevant concentrations (low nM) and in a reversible manner. Moreover, we found that intrabulbar injection of Aβ decreases the olfactory ability of rodents two weeks after application, an effect that is not related to alterations in motor performance or motivation to seek food and that correlates with the presence of Aβ deposits. Our results indicate that Aβ disrupts, at clinically relevant concentrations, the network activity of the OB in vitro and can trigger a disruption in olfaction. These findings open the possibility of exploring the cellular mechanisms involved in early pathological AD as an approach to reduce or halt its progress.Reynaldo Alvarado-MartínezKarla Salgado-PugaFernando Peña-OrtegaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e75745 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Reynaldo Alvarado-Martínez Karla Salgado-Puga Fernando Peña-Ortega Amyloid beta inhibits olfactory bulb activity and the ability to smell.
description	Early olfactory dysfunction has been consistently reported in both Alzheimer's disease (AD) and in transgenic mice that reproduce some features of this disease. In AD transgenic mice, alteration in olfaction has been associated with increased levels of soluble amyloid beta protein (Aβ) as well as with alterations in the oscillatory network activity recorded in the olfactory bulb (OB) and in the piriform cortex. However, since AD is a multifactorial disease and transgenic mice suffer a variety of adaptive changes, it is still unknown if soluble Aβ, by itself, is responsible for OB dysfunction both at electrophysiological and behavioral levels. Thus, here we tested whether or not Aβ directly affects OB network activity in vitro in slices obtained from mice and rats and if it affects olfactory ability in these rodents. Our results show that Aβ decreases, in a concentration- and time-dependent manner, the network activity of OB slices at clinically relevant concentrations (low nM) and in a reversible manner. Moreover, we found that intrabulbar injection of Aβ decreases the olfactory ability of rodents two weeks after application, an effect that is not related to alterations in motor performance or motivation to seek food and that correlates with the presence of Aβ deposits. Our results indicate that Aβ disrupts, at clinically relevant concentrations, the network activity of the OB in vitro and can trigger a disruption in olfaction. These findings open the possibility of exploring the cellular mechanisms involved in early pathological AD as an approach to reduce or halt its progress.
format	article
author	Reynaldo Alvarado-Martínez Karla Salgado-Puga Fernando Peña-Ortega
author_facet	Reynaldo Alvarado-Martínez Karla Salgado-Puga Fernando Peña-Ortega
author_sort	Reynaldo Alvarado-Martínez
title	Amyloid beta inhibits olfactory bulb activity and the ability to smell.
title_short	Amyloid beta inhibits olfactory bulb activity and the ability to smell.
title_full	Amyloid beta inhibits olfactory bulb activity and the ability to smell.
title_fullStr	Amyloid beta inhibits olfactory bulb activity and the ability to smell.
title_full_unstemmed	Amyloid beta inhibits olfactory bulb activity and the ability to smell.
title_sort	amyloid beta inhibits olfactory bulb activity and the ability to smell.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/592e942d23e34e21a80198d0c9f561cf
work_keys_str_mv	AT reynaldoalvaradomartinez amyloidbetainhibitsolfactorybulbactivityandtheabilitytosmell AT karlasalgadopuga amyloidbetainhibitsolfactorybulbactivityandtheabilitytosmell AT fernandopenaortega amyloidbetainhibitsolfactorybulbactivityandtheabilitytosmell
_version_	1718421201824514048

Amyloid beta inhibits olfactory bulb activity and the ability to smell.

Ejemplares similares