HLA-haplotypes and the risk of developing diabetes of type 1 diabetes in the native population of the Nenets Autonomous district

Nenets are Samoyedic people belonging to Ural contact minor race, with combined anthropological signs of both Caucasoid and Mongoloid races. In this population, the occurrences of type 1 diabetes mellitus (T1DM) were registered during 30 years. Aim. The study aimed to investigate the incidence of h...

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Autores principales:	Tamara Leonidovna Kuraeva, Leonid Alexandrovich Zubov, Elena Vinal'evna Titovich, Elena Nikolaevna Sibileva, Olga Nikolaevna Ivanova, Tatyana Yur'evna Shiryeva, Valentina Aleksandrovna Peterkova, Ivan Ivanovich Dedov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2017
Materias:	hla-haplotypes nenets ethnic group russian population Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/5930c0e0bd9c41199a0c48b8fef129a0
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spelling	oai:doaj.org-article:5930c0e0bd9c41199a0c48b8fef129a02021-11-14T09:00:21ZHLA-haplotypes and the risk of developing diabetes of type 1 diabetes in the native population of the Nenets Autonomous district2072-03512072-037810.14341/DM7954https://doaj.org/article/5930c0e0bd9c41199a0c48b8fef129a02017-05-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/7954https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Nenets are Samoyedic people belonging to Ural contact minor race, with combined anthropological signs of both Caucasoid and Mongoloid races. In this population, the occurrences of type 1 diabetes mellitus (T1DM) were registered during 30 years. Aim. The study aimed to investigate the incidence of human leucocyte antigen (HLA)-haplotypes in Nenets compared with those in the Russian population. Materials and Methods. HLA-typing was performed in 61 healthy Nenets subjects residing in the Arkhangelsk district, 341 Russian subjects from Moscow and natives from the Vologda district. Results. DRB104-DQA10301-DQB10302 was similar in all the three study populations: 11.5%, 8.5% and 11.6% for Nenets, Moscow and Vologda populations, respectively (p > 0.05). However, the incidence of the second most important high predisposed haplotype DRB117(03)-DQA10501-DQB10202 was significantly lower in Nenets (1.6%) than in the Moscow and Vologda populations (10% and 7.4%, respectively) [(p1.2 = 0.03 (x2 = 4.42); p1.3 = 0.12 (x2 = 2.46)]. The incidence of DRВ101-DQA10101-DQB10501 haplotype specific for both Russian populations was also significantly lower in Nenets (3.3%) than in the Moscow and Vologda populations (11% and 12.4%, respectively) [(p1.2 < 0.05 (x2 = 3.34); p1.3 < 0.05 (x2 = 3.85)]. The incidence of protected haplotypes (DRB111-DQA10501-DQB10301 and DRB113-DQA10102-DQB10602/8/DRB113-DQA10103-DQB10602) was significantly higher in Nenets than in the Moscow and Vologda populations: 32.8% versus 12.5% and 9.1%, respectively [(p1.2 < 0.001 (x2 = 13.48); p1.3 < 0.001 (x2 = 17.3)] and 16.4% versus 8.5% and 11.1%, respectively [(p1.2 = 0.07 (x2 = 3.14); p1.3 = 0.3 (x2 = 0.97)]. The incidence of some neutral haplotypes was also significantly higher in Nenets: haplotype DRB112-DQA10501-DQB10301 was detected in 29.5% of Nenets compared with 2.5% and 1.2% of the Moscow and Vologda populations, respectively [(p1.2 < 0.001 (x2 = 42.43); p1.3 < 0.001 (x2 = 37.66)]; haplotype DRB109-DQA10301-DQB10303 was detected in 14.8% of Nenets compared with 1% and 2.5% of the Moscow and Vologda populations, respectively [(p1.2 < 0.001 (x2 = 21.9); p1.3 < 0.001 (x2 = 10.04)]. Conclusions. According to preliminary evidence, the incidence of predisposed haplotypes was significantly lower and that of protected haplotypes was significantly higher in Nenets than in the Moscow and Vologda populations, which probably play a role in the very low incidence of T1DM in Nenets.Tamara Leonidovna KuraevaLeonid Alexandrovich ZubovElena Vinal'evna TitovichElena Nikolaevna SibilevaOlga Nikolaevna IvanovaTatyana Yur'evna ShiryevaValentina Aleksandrovna PeterkovaIvan Ivanovich DedovEndocrinology Research Centrearticlehla-haplotypesnenets ethnic grouprussian populationNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 20, Iss 1, Pp 51-58 (2017)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	hla-haplotypes nenets ethnic group russian population Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	hla-haplotypes nenets ethnic group russian population Nutritional diseases. Deficiency diseases RC620-627 Tamara Leonidovna Kuraeva Leonid Alexandrovich Zubov Elena Vinal'evna Titovich Elena Nikolaevna Sibileva Olga Nikolaevna Ivanova Tatyana Yur'evna Shiryeva Valentina Aleksandrovna Peterkova Ivan Ivanovich Dedov HLA-haplotypes and the risk of developing diabetes of type 1 diabetes in the native population of the Nenets Autonomous district
description	Nenets are Samoyedic people belonging to Ural contact minor race, with combined anthropological signs of both Caucasoid and Mongoloid races. In this population, the occurrences of type 1 diabetes mellitus (T1DM) were registered during 30 years. Aim. The study aimed to investigate the incidence of human leucocyte antigen (HLA)-haplotypes in Nenets compared with those in the Russian population. Materials and Methods. HLA-typing was performed in 61 healthy Nenets subjects residing in the Arkhangelsk district, 341 Russian subjects from Moscow and natives from the Vologda district. Results. DRB104-DQA10301-DQB10302 was similar in all the three study populations: 11.5%, 8.5% and 11.6% for Nenets, Moscow and Vologda populations, respectively (p > 0.05). However, the incidence of the second most important high predisposed haplotype DRB117(03)-DQA10501-DQB10202 was significantly lower in Nenets (1.6%) than in the Moscow and Vologda populations (10% and 7.4%, respectively) [(p1.2 = 0.03 (x2 = 4.42); p1.3 = 0.12 (x2 = 2.46)]. The incidence of DRВ101-DQA10101-DQB10501 haplotype specific for both Russian populations was also significantly lower in Nenets (3.3%) than in the Moscow and Vologda populations (11% and 12.4%, respectively) [(p1.2 < 0.05 (x2 = 3.34); p1.3 < 0.05 (x2 = 3.85)]. The incidence of protected haplotypes (DRB111-DQA10501-DQB10301 and DRB113-DQA10102-DQB10602/8/DRB113-DQA10103-DQB10602) was significantly higher in Nenets than in the Moscow and Vologda populations: 32.8% versus 12.5% and 9.1%, respectively [(p1.2 < 0.001 (x2 = 13.48); p1.3 < 0.001 (x2 = 17.3)] and 16.4% versus 8.5% and 11.1%, respectively [(p1.2 = 0.07 (x2 = 3.14); p1.3 = 0.3 (x2 = 0.97)]. The incidence of some neutral haplotypes was also significantly higher in Nenets: haplotype DRB112-DQA10501-DQB10301 was detected in 29.5% of Nenets compared with 2.5% and 1.2% of the Moscow and Vologda populations, respectively [(p1.2 < 0.001 (x2 = 42.43); p1.3 < 0.001 (x2 = 37.66)]; haplotype DRB109-DQA10301-DQB10303 was detected in 14.8% of Nenets compared with 1% and 2.5% of the Moscow and Vologda populations, respectively [(p1.2 < 0.001 (x2 = 21.9); p1.3 < 0.001 (x2 = 10.04)]. Conclusions. According to preliminary evidence, the incidence of predisposed haplotypes was significantly lower and that of protected haplotypes was significantly higher in Nenets than in the Moscow and Vologda populations, which probably play a role in the very low incidence of T1DM in Nenets.
format	article
author	Tamara Leonidovna Kuraeva Leonid Alexandrovich Zubov Elena Vinal'evna Titovich Elena Nikolaevna Sibileva Olga Nikolaevna Ivanova Tatyana Yur'evna Shiryeva Valentina Aleksandrovna Peterkova Ivan Ivanovich Dedov
author_facet	Tamara Leonidovna Kuraeva Leonid Alexandrovich Zubov Elena Vinal'evna Titovich Elena Nikolaevna Sibileva Olga Nikolaevna Ivanova Tatyana Yur'evna Shiryeva Valentina Aleksandrovna Peterkova Ivan Ivanovich Dedov
author_sort	Tamara Leonidovna Kuraeva
title	HLA-haplotypes and the risk of developing diabetes of type 1 diabetes in the native population of the Nenets Autonomous district
title_short	HLA-haplotypes and the risk of developing diabetes of type 1 diabetes in the native population of the Nenets Autonomous district
title_full	HLA-haplotypes and the risk of developing diabetes of type 1 diabetes in the native population of the Nenets Autonomous district
title_fullStr	HLA-haplotypes and the risk of developing diabetes of type 1 diabetes in the native population of the Nenets Autonomous district
title_full_unstemmed	HLA-haplotypes and the risk of developing diabetes of type 1 diabetes in the native population of the Nenets Autonomous district
title_sort	hla-haplotypes and the risk of developing diabetes of type 1 diabetes in the native population of the nenets autonomous district
publisher	Endocrinology Research Centre
publishDate	2017
url	https://doaj.org/article/5930c0e0bd9c41199a0c48b8fef129a0
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HLA-haplotypes and the risk of developing diabetes of type 1 diabetes in the native population of the Nenets Autonomous district

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