Induction of remission in chronic urticaria by immunotherapy using immunoglobulin/histamine complex (Histobulin™): a case report

Abstract Background Symptom control is a major concern in chronic urticaria. Histobulin™ is a histamine/immunoglobulin complex that has been approved for allergic rhinitis, bronchial asthma and chronic urticaria in some countries. Not only has the immunoglobulin/histamine complex been reported to be...

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Autores principales:	Hyuk Soon Kim, Geunwoong Noh
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Chronic spontaneous urticaria Immunoglobulin/histamine complex Histobulin™ Remission Immunotherapy Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/5931bdef1c364fd3899a7391b6c3a296
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spelling	oai:doaj.org-article:5931bdef1c364fd3899a7391b6c3a2962021-11-14T12:37:12ZInduction of remission in chronic urticaria by immunotherapy using immunoglobulin/histamine complex (Histobulin™): a case report10.1186/s13223-021-00612-81710-1492https://doaj.org/article/5931bdef1c364fd3899a7391b6c3a2962021-11-01T00:00:00Zhttps://doi.org/10.1186/s13223-021-00612-8https://doaj.org/toc/1710-1492Abstract Background Symptom control is a major concern in chronic urticaria. Histobulin™ is a histamine/immunoglobulin complex that has been approved for allergic rhinitis, bronchial asthma and chronic urticaria in some countries. Not only has the immunoglobulin/histamine complex been reported to be effective in allergic diseases, including chronic urticaria, but recently, the possibility of remission induction in chronic urticaria by the immunoglobulin/histamine complex has been reported. Case presentation Histobulin™ was administered until remission was induced instead of fixing the number of administrations in four cases of chronic urticaria. Two patients showed an early response and finished treatment with 12 injections of Histobulin™, and the other two patients showed a late response and were injected 43 and 46 times. Remission was induced successfully in all four cases. Conclusions Histobulin™ is not only effective but also induces remission in CSU. The Histobulin™ therapy protocol in CSU may be better if the treatment is continued until remission is achieved. Based on the responses of the patients, early responders and late responders were present. The progression of the disease during treatment consisted of a slow improvement phase and a rapid improvement phase. Uniquely, the appropriate allergy laboratory results, including blood eosinophil fraction, total IgE and eosinophil cationic protein level, were normal in all 4 cases. Further studies concerning the mechanisms of Histobulin™ may be needed.Hyuk Soon KimGeunwoong NohBMCarticleChronic spontaneous urticariaImmunoglobulin/histamine complexHistobulin™RemissionImmunotherapyImmunologic diseases. AllergyRC581-607ENAllergy, Asthma & Clinical Immunology, Vol 17, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chronic spontaneous urticaria Immunoglobulin/histamine complex Histobulin™ Remission Immunotherapy Immunologic diseases. Allergy RC581-607
spellingShingle	Chronic spontaneous urticaria Immunoglobulin/histamine complex Histobulin™ Remission Immunotherapy Immunologic diseases. Allergy RC581-607 Hyuk Soon Kim Geunwoong Noh Induction of remission in chronic urticaria by immunotherapy using immunoglobulin/histamine complex (Histobulin™): a case report
description	Abstract Background Symptom control is a major concern in chronic urticaria. Histobulin™ is a histamine/immunoglobulin complex that has been approved for allergic rhinitis, bronchial asthma and chronic urticaria in some countries. Not only has the immunoglobulin/histamine complex been reported to be effective in allergic diseases, including chronic urticaria, but recently, the possibility of remission induction in chronic urticaria by the immunoglobulin/histamine complex has been reported. Case presentation Histobulin™ was administered until remission was induced instead of fixing the number of administrations in four cases of chronic urticaria. Two patients showed an early response and finished treatment with 12 injections of Histobulin™, and the other two patients showed a late response and were injected 43 and 46 times. Remission was induced successfully in all four cases. Conclusions Histobulin™ is not only effective but also induces remission in CSU. The Histobulin™ therapy protocol in CSU may be better if the treatment is continued until remission is achieved. Based on the responses of the patients, early responders and late responders were present. The progression of the disease during treatment consisted of a slow improvement phase and a rapid improvement phase. Uniquely, the appropriate allergy laboratory results, including blood eosinophil fraction, total IgE and eosinophil cationic protein level, were normal in all 4 cases. Further studies concerning the mechanisms of Histobulin™ may be needed.
format	article
author	Hyuk Soon Kim Geunwoong Noh
author_facet	Hyuk Soon Kim Geunwoong Noh
author_sort	Hyuk Soon Kim
title	Induction of remission in chronic urticaria by immunotherapy using immunoglobulin/histamine complex (Histobulin™): a case report
title_short	Induction of remission in chronic urticaria by immunotherapy using immunoglobulin/histamine complex (Histobulin™): a case report
title_full	Induction of remission in chronic urticaria by immunotherapy using immunoglobulin/histamine complex (Histobulin™): a case report
title_fullStr	Induction of remission in chronic urticaria by immunotherapy using immunoglobulin/histamine complex (Histobulin™): a case report
title_full_unstemmed	Induction of remission in chronic urticaria by immunotherapy using immunoglobulin/histamine complex (Histobulin™): a case report
title_sort	induction of remission in chronic urticaria by immunotherapy using immunoglobulin/histamine complex (histobulin™): a case report
publisher	BMC
publishDate	2021
url	https://doaj.org/article/5931bdef1c364fd3899a7391b6c3a296
work_keys_str_mv	AT hyuksoonkim inductionofremissioninchronicurticariabyimmunotherapyusingimmunoglobulinhistaminecomplexhistobulinacasereport AT geunwoongnoh inductionofremissioninchronicurticariabyimmunotherapyusingimmunoglobulinhistaminecomplexhistobulinacasereport
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Induction of remission in chronic urticaria by immunotherapy using immunoglobulin/histamine complex (Histobulin™): a case report

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