Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention

VIP interneurons have been shown to disinhibit pyramidal neurons by inhibiting other interneuron types. Here, the authors report that ChAT-VIP subtype of interneurons directly excite pyramidal neurons in multiple layers via fast cholinergic neurotransmission.

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Autores principales:	Joshua Obermayer, Antonio Luchicchi, Tim S. Heistek, Sybren F. de Kloet, Huub Terra, Bastiaan Bruinsma, Ouissame Mnie-Filali, Christian Kortleven, Anna A. Galakhova, Ayoub J. Khalil, Tim Kroon, Allert J. Jonker, Roel de Haan, Wilma D. J. van de Berg, Natalia A. Goriounova, Christiaan P. J. de Kock, Tommy Pattij, Huibert D. Mansvelder
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/59339fd0ec524e8d8a59a8fece53b4cb
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spelling	oai:doaj.org-article:59339fd0ec524e8d8a59a8fece53b4cb2021-12-02T14:35:50ZPrefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention10.1038/s41467-019-13244-92041-1723https://doaj.org/article/59339fd0ec524e8d8a59a8fece53b4cb2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13244-9https://doaj.org/toc/2041-1723VIP interneurons have been shown to disinhibit pyramidal neurons by inhibiting other interneuron types. Here, the authors report that ChAT-VIP subtype of interneurons directly excite pyramidal neurons in multiple layers via fast cholinergic neurotransmission.Joshua ObermayerAntonio LuchicchiTim S. HeistekSybren F. de KloetHuub TerraBastiaan BruinsmaOuissame Mnie-FilaliChristian KortlevenAnna A. GalakhovaAyoub J. KhalilTim KroonAllert J. JonkerRoel de HaanWilma D. J. van de BergNatalia A. GoriounovaChristiaan P. J. de KockTommy PattijHuibert D. MansvelderNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joshua Obermayer Antonio Luchicchi Tim S. Heistek Sybren F. de Kloet Huub Terra Bastiaan Bruinsma Ouissame Mnie-Filali Christian Kortleven Anna A. Galakhova Ayoub J. Khalil Tim Kroon Allert J. Jonker Roel de Haan Wilma D. J. van de Berg Natalia A. Goriounova Christiaan P. J. de Kock Tommy Pattij Huibert D. Mansvelder Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention
description	VIP interneurons have been shown to disinhibit pyramidal neurons by inhibiting other interneuron types. Here, the authors report that ChAT-VIP subtype of interneurons directly excite pyramidal neurons in multiple layers via fast cholinergic neurotransmission.
format	article
author	Joshua Obermayer Antonio Luchicchi Tim S. Heistek Sybren F. de Kloet Huub Terra Bastiaan Bruinsma Ouissame Mnie-Filali Christian Kortleven Anna A. Galakhova Ayoub J. Khalil Tim Kroon Allert J. Jonker Roel de Haan Wilma D. J. van de Berg Natalia A. Goriounova Christiaan P. J. de Kock Tommy Pattij Huibert D. Mansvelder
author_facet	Joshua Obermayer Antonio Luchicchi Tim S. Heistek Sybren F. de Kloet Huub Terra Bastiaan Bruinsma Ouissame Mnie-Filali Christian Kortleven Anna A. Galakhova Ayoub J. Khalil Tim Kroon Allert J. Jonker Roel de Haan Wilma D. J. van de Berg Natalia A. Goriounova Christiaan P. J. de Kock Tommy Pattij Huibert D. Mansvelder
author_sort	Joshua Obermayer
title	Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention
title_short	Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention
title_full	Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention
title_fullStr	Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention
title_full_unstemmed	Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention
title_sort	prefrontal cortical chat-vip interneurons provide local excitation by cholinergic synaptic transmission and control attention
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/59339fd0ec524e8d8a59a8fece53b4cb
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Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention

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