REGULATORY T CELLS IN CHILDREN WITH ALLERGY

Abstract. Percentage of CD4+CD25hi is increased in children with allergy, and it is independent on their nosology, severity, sensitization and IgE level in blood. FOXP3 expression virtually was not altered. Inhalation of corticosteroids in asthma causes increase of FOXP3 expression that may represen...

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Autores principales:	A. Donetskova, N. Sharova, M. Litvina, O. Burmenskaya, D. Trofimov, M. Yartsev, L. Alexeev, A. Yarilin
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	regulatory t-cells cd4+cd25hi foxp3 allergy children Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/593497381ab94796868d1ae2861b365b
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spelling	oai:doaj.org-article:593497381ab94796868d1ae2861b365b2021-11-18T08:03:38ZREGULATORY T CELLS IN CHILDREN WITH ALLERGY1563-06252313-741X10.15789/1563-0625-2008-2-3-159-166https://doaj.org/article/593497381ab94796868d1ae2861b365b2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/120https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Percentage of CD4+CD25hi is increased in children with allergy, and it is independent on their nosology, severity, sensitization and IgE level in blood. FOXP3 expression virtually was not altered. Inhalation of corticosteroids in asthma causes increase of FOXP3 expression that may represent some mechanisms of their therapeutic effects. The amount of Treg’s gradually decrease with age in non-atopic children; they also decrease in atopic ones until 6 years, followed by their subsequent stabilization. Thus, a hypothesis is proposed, that the initial changes of Treg’s in case of allergy comprise a reduction in their functions, and, upon complete or partial compensation of this defect by increasing of cell amounts, a remission is initiated. However, in absence of compensation, acute attacks of allergic disorders are developed. (Med. Immunol., 2008, vol. 10, N 2-3, pp 159-166).A. DonetskovaN. SharovaM. LitvinaO. BurmenskayaD. TrofimovM. YartsevL. AlexeevA. YarilinSPb RAACIarticleregulatory t-cellscd4+cd25hifoxp3allergychildrenImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 2-3, Pp 159-166 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	regulatory t-cells cd4+cd25hi foxp3 allergy children Immunologic diseases. Allergy RC581-607
spellingShingle	regulatory t-cells cd4+cd25hi foxp3 allergy children Immunologic diseases. Allergy RC581-607 A. Donetskova N. Sharova M. Litvina O. Burmenskaya D. Trofimov M. Yartsev L. Alexeev A. Yarilin REGULATORY T CELLS IN CHILDREN WITH ALLERGY
description	Abstract. Percentage of CD4+CD25hi is increased in children with allergy, and it is independent on their nosology, severity, sensitization and IgE level in blood. FOXP3 expression virtually was not altered. Inhalation of corticosteroids in asthma causes increase of FOXP3 expression that may represent some mechanisms of their therapeutic effects. The amount of Treg’s gradually decrease with age in non-atopic children; they also decrease in atopic ones until 6 years, followed by their subsequent stabilization. Thus, a hypothesis is proposed, that the initial changes of Treg’s in case of allergy comprise a reduction in their functions, and, upon complete or partial compensation of this defect by increasing of cell amounts, a remission is initiated. However, in absence of compensation, acute attacks of allergic disorders are developed. (Med. Immunol., 2008, vol. 10, N 2-3, pp 159-166).
format	article
author	A. Donetskova N. Sharova M. Litvina O. Burmenskaya D. Trofimov M. Yartsev L. Alexeev A. Yarilin
author_facet	A. Donetskova N. Sharova M. Litvina O. Burmenskaya D. Trofimov M. Yartsev L. Alexeev A. Yarilin
author_sort	A. Donetskova
title	REGULATORY T CELLS IN CHILDREN WITH ALLERGY
title_short	REGULATORY T CELLS IN CHILDREN WITH ALLERGY
title_full	REGULATORY T CELLS IN CHILDREN WITH ALLERGY
title_fullStr	REGULATORY T CELLS IN CHILDREN WITH ALLERGY
title_full_unstemmed	REGULATORY T CELLS IN CHILDREN WITH ALLERGY
title_sort	regulatory t cells in children with allergy
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/593497381ab94796868d1ae2861b365b
work_keys_str_mv	AT adonetskova regulatorytcellsinchildrenwithallergy AT nsharova regulatorytcellsinchildrenwithallergy AT mlitvina regulatorytcellsinchildrenwithallergy AT oburmenskaya regulatorytcellsinchildrenwithallergy AT dtrofimov regulatorytcellsinchildrenwithallergy AT myartsev regulatorytcellsinchildrenwithallergy AT lalexeev regulatorytcellsinchildrenwithallergy AT ayarilin regulatorytcellsinchildrenwithallergy
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REGULATORY T CELLS IN CHILDREN WITH ALLERGY

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