Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics
Cysteine hydropersulfides (CysSSH) are believed to have a cellular redox protective role. Here the authors show that these species can be produced from L-cysteine by cysteinyl-tRNA synthetases and that these enzymes are also involved in mitochondrial biogenesis and bioenergetics regulation.
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Nature Portfolio
2017
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oai:doaj.org-article:59355d393d744dc18b1812f57d180eae2021-12-02T14:40:58ZCysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics10.1038/s41467-017-01311-y2041-1723https://doaj.org/article/59355d393d744dc18b1812f57d180eae2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01311-yhttps://doaj.org/toc/2041-1723Cysteine hydropersulfides (CysSSH) are believed to have a cellular redox protective role. Here the authors show that these species can be produced from L-cysteine by cysteinyl-tRNA synthetases and that these enzymes are also involved in mitochondrial biogenesis and bioenergetics regulation.Takaaki AkaikeTomoaki IdaFan-Yan WeiMotohiro NishidaYoshito KumagaiMd. Morshedul AlamHideshi IharaTomohiro SawaTetsuro MatsunagaShingo KasamatsuAkiyuki NishimuraMasanobu MoritaKazuhito TomizawaAkira NishimuraSatoshi WatanabeKenji InabaHiroshi ShimaNobuhiro TanumaMinkyung JungShigemoto FujiiYasuo WatanabeMasaki OhmurayaPéter NagyMartin FeelischJon M. FukutoHozumi MotohashiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017) |
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Science Q Takaaki Akaike Tomoaki Ida Fan-Yan Wei Motohiro Nishida Yoshito Kumagai Md. Morshedul Alam Hideshi Ihara Tomohiro Sawa Tetsuro Matsunaga Shingo Kasamatsu Akiyuki Nishimura Masanobu Morita Kazuhito Tomizawa Akira Nishimura Satoshi Watanabe Kenji Inaba Hiroshi Shima Nobuhiro Tanuma Minkyung Jung Shigemoto Fujii Yasuo Watanabe Masaki Ohmuraya Péter Nagy Martin Feelisch Jon M. Fukuto Hozumi Motohashi Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics |
| description |
Cysteine hydropersulfides (CysSSH) are believed to have a cellular redox protective role. Here the authors show that these species can be produced from L-cysteine by cysteinyl-tRNA synthetases and that these enzymes are also involved in mitochondrial biogenesis and bioenergetics regulation. |
| format |
article |
| author |
Takaaki Akaike Tomoaki Ida Fan-Yan Wei Motohiro Nishida Yoshito Kumagai Md. Morshedul Alam Hideshi Ihara Tomohiro Sawa Tetsuro Matsunaga Shingo Kasamatsu Akiyuki Nishimura Masanobu Morita Kazuhito Tomizawa Akira Nishimura Satoshi Watanabe Kenji Inaba Hiroshi Shima Nobuhiro Tanuma Minkyung Jung Shigemoto Fujii Yasuo Watanabe Masaki Ohmuraya Péter Nagy Martin Feelisch Jon M. Fukuto Hozumi Motohashi |
| author_facet |
Takaaki Akaike Tomoaki Ida Fan-Yan Wei Motohiro Nishida Yoshito Kumagai Md. Morshedul Alam Hideshi Ihara Tomohiro Sawa Tetsuro Matsunaga Shingo Kasamatsu Akiyuki Nishimura Masanobu Morita Kazuhito Tomizawa Akira Nishimura Satoshi Watanabe Kenji Inaba Hiroshi Shima Nobuhiro Tanuma Minkyung Jung Shigemoto Fujii Yasuo Watanabe Masaki Ohmuraya Péter Nagy Martin Feelisch Jon M. Fukuto Hozumi Motohashi |
| author_sort |
Takaaki Akaike |
| title |
Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics |
| title_short |
Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics |
| title_full |
Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics |
| title_fullStr |
Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics |
| title_full_unstemmed |
Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics |
| title_sort |
cysteinyl-trna synthetase governs cysteine polysulfidation and mitochondrial bioenergetics |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/59355d393d744dc18b1812f57d180eae |
| work_keys_str_mv |
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