Biomarkers and Fever in Children with Cancer: Kinetics and Levels According to Final Diagnosis

We investigated the kinetics of CRP, PCT, IL-6 and MR-proADM in a cohort of consecutive febrile patients with cancer in order to test the hypothesis that higher plasma concentrations and the absence of a rapid decrease in peak values would be associated with disease severity. (1) Method: A prospecti...

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Autores principales:	Ana de Lucio Delgado, Jose Antonio Villegas Rubio, Corsino Rey Galan, Belen Prieto García, Maria de los Reyes González Expósito, Gonzalo Solís Sánchez
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cancer children fever Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/5935da066f0440cea8a868e405d7a0b3
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spelling	oai:doaj.org-article:5935da066f0440cea8a868e405d7a0b32021-11-25T17:14:39ZBiomarkers and Fever in Children with Cancer: Kinetics and Levels According to Final Diagnosis10.3390/children81110272227-9067https://doaj.org/article/5935da066f0440cea8a868e405d7a0b32021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9067/8/11/1027https://doaj.org/toc/2227-9067We investigated the kinetics of CRP, PCT, IL-6 and MR-proADM in a cohort of consecutive febrile patients with cancer in order to test the hypothesis that higher plasma concentrations and the absence of a rapid decrease in peak values would be associated with disease severity. (1) Method: A prospective descriptive and analytical study of patients with cancer and fever (≤18 years of age) at a University Hospital was carried out between January 2018 and December 2019. Information collected: sex, age, diagnosis, date and symptoms at diagnosis and medical history. The episodes were classified into three groups: bacterial infection, non-bacterial infection and systemic inflammatory response syndrome (SIRS). (2) Results: One hundred and thirty-four episodes were included. Bacterial infection criteria were met in 38 episodes. Biomarkers were measured at four different points: baseline, at 12–24 h, at 25–48 h and at 49–72 h. All the biomarkers evaluated decreased after the peak level was reached. IL-6 and MR-proADM showed a trend towards higher levels in the SIRS group although this rise was statistically significant only for IL-6 (<i>p</i> < 0.005). Bacterial infections more frequently presented values of PCT above the cut-off point (>0.5 ng/mL) at 12–24 h. (3) Conclusion: In our experience, IL-6 kinetics is faster than PCT kinetics and both are faster than CRP in patients with fever and cancer who present a good outcome. Patients with a good evolution show a rapid increase and decrease of PCT and particularly of IL-6 levels.Ana de Lucio DelgadoJose Antonio Villegas RubioCorsino Rey GalanBelen Prieto GarcíaMaria de los Reyes González ExpósitoGonzalo Solís SánchezMDPI AGarticlecancerchildrenfeverPediatricsRJ1-570ENChildren, Vol 8, Iss 1027, p 1027 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer children fever Pediatrics RJ1-570
spellingShingle	cancer children fever Pediatrics RJ1-570 Ana de Lucio Delgado Jose Antonio Villegas Rubio Corsino Rey Galan Belen Prieto García Maria de los Reyes González Expósito Gonzalo Solís Sánchez Biomarkers and Fever in Children with Cancer: Kinetics and Levels According to Final Diagnosis
description	We investigated the kinetics of CRP, PCT, IL-6 and MR-proADM in a cohort of consecutive febrile patients with cancer in order to test the hypothesis that higher plasma concentrations and the absence of a rapid decrease in peak values would be associated with disease severity. (1) Method: A prospective descriptive and analytical study of patients with cancer and fever (≤18 years of age) at a University Hospital was carried out between January 2018 and December 2019. Information collected: sex, age, diagnosis, date and symptoms at diagnosis and medical history. The episodes were classified into three groups: bacterial infection, non-bacterial infection and systemic inflammatory response syndrome (SIRS). (2) Results: One hundred and thirty-four episodes were included. Bacterial infection criteria were met in 38 episodes. Biomarkers were measured at four different points: baseline, at 12–24 h, at 25–48 h and at 49–72 h. All the biomarkers evaluated decreased after the peak level was reached. IL-6 and MR-proADM showed a trend towards higher levels in the SIRS group although this rise was statistically significant only for IL-6 (<i>p</i> < 0.005). Bacterial infections more frequently presented values of PCT above the cut-off point (>0.5 ng/mL) at 12–24 h. (3) Conclusion: In our experience, IL-6 kinetics is faster than PCT kinetics and both are faster than CRP in patients with fever and cancer who present a good outcome. Patients with a good evolution show a rapid increase and decrease of PCT and particularly of IL-6 levels.
format	article
author	Ana de Lucio Delgado Jose Antonio Villegas Rubio Corsino Rey Galan Belen Prieto García Maria de los Reyes González Expósito Gonzalo Solís Sánchez
author_facet	Ana de Lucio Delgado Jose Antonio Villegas Rubio Corsino Rey Galan Belen Prieto García Maria de los Reyes González Expósito Gonzalo Solís Sánchez
author_sort	Ana de Lucio Delgado
title	Biomarkers and Fever in Children with Cancer: Kinetics and Levels According to Final Diagnosis
title_short	Biomarkers and Fever in Children with Cancer: Kinetics and Levels According to Final Diagnosis
title_full	Biomarkers and Fever in Children with Cancer: Kinetics and Levels According to Final Diagnosis
title_fullStr	Biomarkers and Fever in Children with Cancer: Kinetics and Levels According to Final Diagnosis
title_full_unstemmed	Biomarkers and Fever in Children with Cancer: Kinetics and Levels According to Final Diagnosis
title_sort	biomarkers and fever in children with cancer: kinetics and levels according to final diagnosis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5935da066f0440cea8a868e405d7a0b3
work_keys_str_mv	AT anadeluciodelgado biomarkersandfeverinchildrenwithcancerkineticsandlevelsaccordingtofinaldiagnosis AT joseantoniovillegasrubio biomarkersandfeverinchildrenwithcancerkineticsandlevelsaccordingtofinaldiagnosis AT corsinoreygalan biomarkersandfeverinchildrenwithcancerkineticsandlevelsaccordingtofinaldiagnosis AT belenprietogarcia biomarkersandfeverinchildrenwithcancerkineticsandlevelsaccordingtofinaldiagnosis AT mariadelosreyesgonzalezexposito biomarkersandfeverinchildrenwithcancerkineticsandlevelsaccordingtofinaldiagnosis AT gonzalosolissanchez biomarkersandfeverinchildrenwithcancerkineticsandlevelsaccordingtofinaldiagnosis
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Biomarkers and Fever in Children with Cancer: Kinetics and Levels According to Final Diagnosis

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