COVID-19, Pre-Eclampsia, and Complement System
COVID-19 is characterized by virus-induced injury leading to multi-organ failure, together with inflammatory reaction, endothelial cell (EC) injury, and prothrombotic coagulopathy with thrombotic events. Complement system (C) via its cross-talk with the contact and coagulation systems contributes si...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:59369b24b5f240af879ca109bfa64a582021-11-17T07:03:32ZCOVID-19, Pre-Eclampsia, and Complement System1664-322410.3389/fimmu.2021.775168https://doaj.org/article/59369b24b5f240af879ca109bfa64a582021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.775168/fullhttps://doaj.org/toc/1664-3224COVID-19 is characterized by virus-induced injury leading to multi-organ failure, together with inflammatory reaction, endothelial cell (EC) injury, and prothrombotic coagulopathy with thrombotic events. Complement system (C) via its cross-talk with the contact and coagulation systems contributes significantly to the severity and pathological consequences due to SARS-CoV-2 infection. These immunopathological mechanisms overlap in COVID-19 and pre-eclampsia (PE). Thus, mothers contracting SARS-CoV-2 infection during pregnancy are more vulnerable to developing PE. SARS-CoV-2 infection of ECs, via its receptor ACE2 and co-receptor TMPRSS2, can provoke endothelial dysfunction and disruption of vascular integrity, causing hyperinflammation and hypercoagulability. This is aggravated by bradykinin increase due to inhibition of ACE2 activity by the virus. C is important for the progression of normal pregnancy, and its dysregulation can impact in the form of PE-like syndrome as a consequence of SARS-CoV-2 infection. Thus, there is also an overlap between treatment regimens of COVID-19 and PE. C inhibitors, especially those targeting C3 or MASP-2, are exciting options for treating COVID-19 and consequent PE. In this review, we examine the role of C, contact and coagulation systems as well as endothelial hyperactivation with respect to SARS-CoV-2 infection during pregnancy and likely development of PE.Chiara AgostinisAlessandro MangognaAndrea BalduitAzin AghamajidiGiuseppe RicciGiuseppe RicciUday KishoreRoberta BullaFrontiers Media S.A.articleCOVID-19complement systemSARS-CoV-2pregnancypre-eclampsiaImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
COVID-19 complement system SARS-CoV-2 pregnancy pre-eclampsia Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
COVID-19 complement system SARS-CoV-2 pregnancy pre-eclampsia Immunologic diseases. Allergy RC581-607 Chiara Agostinis Alessandro Mangogna Andrea Balduit Azin Aghamajidi Giuseppe Ricci Giuseppe Ricci Uday Kishore Roberta Bulla COVID-19, Pre-Eclampsia, and Complement System |
| description |
COVID-19 is characterized by virus-induced injury leading to multi-organ failure, together with inflammatory reaction, endothelial cell (EC) injury, and prothrombotic coagulopathy with thrombotic events. Complement system (C) via its cross-talk with the contact and coagulation systems contributes significantly to the severity and pathological consequences due to SARS-CoV-2 infection. These immunopathological mechanisms overlap in COVID-19 and pre-eclampsia (PE). Thus, mothers contracting SARS-CoV-2 infection during pregnancy are more vulnerable to developing PE. SARS-CoV-2 infection of ECs, via its receptor ACE2 and co-receptor TMPRSS2, can provoke endothelial dysfunction and disruption of vascular integrity, causing hyperinflammation and hypercoagulability. This is aggravated by bradykinin increase due to inhibition of ACE2 activity by the virus. C is important for the progression of normal pregnancy, and its dysregulation can impact in the form of PE-like syndrome as a consequence of SARS-CoV-2 infection. Thus, there is also an overlap between treatment regimens of COVID-19 and PE. C inhibitors, especially those targeting C3 or MASP-2, are exciting options for treating COVID-19 and consequent PE. In this review, we examine the role of C, contact and coagulation systems as well as endothelial hyperactivation with respect to SARS-CoV-2 infection during pregnancy and likely development of PE. |
| format |
article |
| author |
Chiara Agostinis Alessandro Mangogna Andrea Balduit Azin Aghamajidi Giuseppe Ricci Giuseppe Ricci Uday Kishore Roberta Bulla |
| author_facet |
Chiara Agostinis Alessandro Mangogna Andrea Balduit Azin Aghamajidi Giuseppe Ricci Giuseppe Ricci Uday Kishore Roberta Bulla |
| author_sort |
Chiara Agostinis |
| title |
COVID-19, Pre-Eclampsia, and Complement System |
| title_short |
COVID-19, Pre-Eclampsia, and Complement System |
| title_full |
COVID-19, Pre-Eclampsia, and Complement System |
| title_fullStr |
COVID-19, Pre-Eclampsia, and Complement System |
| title_full_unstemmed |
COVID-19, Pre-Eclampsia, and Complement System |
| title_sort |
covid-19, pre-eclampsia, and complement system |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/59369b24b5f240af879ca109bfa64a58 |
| work_keys_str_mv |
AT chiaraagostinis covid19preeclampsiaandcomplementsystem AT alessandromangogna covid19preeclampsiaandcomplementsystem AT andreabalduit covid19preeclampsiaandcomplementsystem AT azinaghamajidi covid19preeclampsiaandcomplementsystem AT giuseppericci covid19preeclampsiaandcomplementsystem AT giuseppericci covid19preeclampsiaandcomplementsystem AT udaykishore covid19preeclampsiaandcomplementsystem AT robertabulla covid19preeclampsiaandcomplementsystem |
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1718425859332767744 |