Exploring chemoselective S-to-N acyl transfer reactions in synthesis and chemical biology

The conversion of thioesters to amides via acyl transfer has become one of the most important synthetic techniques for the chemical synthesis and modification of proteins. This review discusses this S-to-N acyl transfer process, and highlights some of the key applications across chemistry and biolog...

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Autores principales: Helen M. Burke, Lauren McSweeney, Eoin M. Scanlan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/59417d48b6dc4b2da4db6f05832ae640
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Sumario:The conversion of thioesters to amides via acyl transfer has become one of the most important synthetic techniques for the chemical synthesis and modification of proteins. This review discusses this S-to-N acyl transfer process, and highlights some of the key applications across chemistry and biology.