The feasibility of the PAM intervention to support treatment-adherence in people with hypertension in primary care: a randomised clinical controlled trial
Abstract The PAM intervention is a behavioural intervention to support adherence to anti-hypertensive medications and therefore to lower blood pressure. This feasibility trial recruited 101 nonadherent patients (54% male, mean age 65.8 years) with hypertension and high blood pressure from nine gener...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/59427baaaf3a4b5ea2a458160e3fff18 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:59427baaaf3a4b5ea2a458160e3fff18 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:59427baaaf3a4b5ea2a458160e3fff182021-12-02T17:39:31ZThe feasibility of the PAM intervention to support treatment-adherence in people with hypertension in primary care: a randomised clinical controlled trial10.1038/s41598-021-88170-22045-2322https://doaj.org/article/59427baaaf3a4b5ea2a458160e3fff182021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88170-2https://doaj.org/toc/2045-2322Abstract The PAM intervention is a behavioural intervention to support adherence to anti-hypertensive medications and therefore to lower blood pressure. This feasibility trial recruited 101 nonadherent patients (54% male, mean age 65.8 years) with hypertension and high blood pressure from nine general practices in the UK. The trial had 15.5% uptake and 7.9% attrition rate. Patients were randomly allocated to two groups: the intervention group (n = 61) received the PAM intervention as an adjunct to usual care; the control group (n = 40) received usual care only. At 3 months, biochemically validated medication adherence was improved by 20% (95% CI 3–36%) in the intervention than control, and systolic blood pressure was reduced by 9.16 mmHg (95% CI 5.69–12.64) in intervention than control. Improvements in medication adherence and reductions in blood pressure suggested potential intervention effectiveness. For a subsample of patients, improvements in medication adherence and reductions in full lipid profile (cholesterol 1.39 mmol/mol 95% CI 0.64–1.40) and in glycated haemoglobin (3.08 mmol/mol, 95% CI 0.42–5.73) favoured the intervention. A larger trial will obtain rigorous evidence about the potential clinical effectiveness and cost-effectiveness of the intervention. Trial registration Trial date of first registration 28/01/2019. ISRCTN74504989. https://doi.org/10.1186/ISRCTN74504989 .Aikaterini KassavouVenus MirzaeiSonia ShpendiJames BrimicombeJagmohan ChauhanDebi BhattacharyaFelix NaughtonWendy HardemanHelen EborallMiranda Van EmmenisAnna De SimoniAmrit TakharPankaj GuptaPrashanth PatelCecilia MascoloAndrew Toby PrevostStephen MorrisSimon GriffinRichard J. McManusJonathan MantStephen SuttonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Aikaterini Kassavou Venus Mirzaei Sonia Shpendi James Brimicombe Jagmohan Chauhan Debi Bhattacharya Felix Naughton Wendy Hardeman Helen Eborall Miranda Van Emmenis Anna De Simoni Amrit Takhar Pankaj Gupta Prashanth Patel Cecilia Mascolo Andrew Toby Prevost Stephen Morris Simon Griffin Richard J. McManus Jonathan Mant Stephen Sutton The feasibility of the PAM intervention to support treatment-adherence in people with hypertension in primary care: a randomised clinical controlled trial |
| description |
Abstract The PAM intervention is a behavioural intervention to support adherence to anti-hypertensive medications and therefore to lower blood pressure. This feasibility trial recruited 101 nonadherent patients (54% male, mean age 65.8 years) with hypertension and high blood pressure from nine general practices in the UK. The trial had 15.5% uptake and 7.9% attrition rate. Patients were randomly allocated to two groups: the intervention group (n = 61) received the PAM intervention as an adjunct to usual care; the control group (n = 40) received usual care only. At 3 months, biochemically validated medication adherence was improved by 20% (95% CI 3–36%) in the intervention than control, and systolic blood pressure was reduced by 9.16 mmHg (95% CI 5.69–12.64) in intervention than control. Improvements in medication adherence and reductions in blood pressure suggested potential intervention effectiveness. For a subsample of patients, improvements in medication adherence and reductions in full lipid profile (cholesterol 1.39 mmol/mol 95% CI 0.64–1.40) and in glycated haemoglobin (3.08 mmol/mol, 95% CI 0.42–5.73) favoured the intervention. A larger trial will obtain rigorous evidence about the potential clinical effectiveness and cost-effectiveness of the intervention. Trial registration Trial date of first registration 28/01/2019. ISRCTN74504989. https://doi.org/10.1186/ISRCTN74504989 . |
| format |
article |
| author |
Aikaterini Kassavou Venus Mirzaei Sonia Shpendi James Brimicombe Jagmohan Chauhan Debi Bhattacharya Felix Naughton Wendy Hardeman Helen Eborall Miranda Van Emmenis Anna De Simoni Amrit Takhar Pankaj Gupta Prashanth Patel Cecilia Mascolo Andrew Toby Prevost Stephen Morris Simon Griffin Richard J. McManus Jonathan Mant Stephen Sutton |
| author_facet |
Aikaterini Kassavou Venus Mirzaei Sonia Shpendi James Brimicombe Jagmohan Chauhan Debi Bhattacharya Felix Naughton Wendy Hardeman Helen Eborall Miranda Van Emmenis Anna De Simoni Amrit Takhar Pankaj Gupta Prashanth Patel Cecilia Mascolo Andrew Toby Prevost Stephen Morris Simon Griffin Richard J. McManus Jonathan Mant Stephen Sutton |
| author_sort |
Aikaterini Kassavou |
| title |
The feasibility of the PAM intervention to support treatment-adherence in people with hypertension in primary care: a randomised clinical controlled trial |
| title_short |
The feasibility of the PAM intervention to support treatment-adherence in people with hypertension in primary care: a randomised clinical controlled trial |
| title_full |
The feasibility of the PAM intervention to support treatment-adherence in people with hypertension in primary care: a randomised clinical controlled trial |
| title_fullStr |
The feasibility of the PAM intervention to support treatment-adherence in people with hypertension in primary care: a randomised clinical controlled trial |
| title_full_unstemmed |
The feasibility of the PAM intervention to support treatment-adherence in people with hypertension in primary care: a randomised clinical controlled trial |
| title_sort |
feasibility of the pam intervention to support treatment-adherence in people with hypertension in primary care: a randomised clinical controlled trial |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/59427baaaf3a4b5ea2a458160e3fff18 |
| work_keys_str_mv |
AT aikaterinikassavou thefeasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT venusmirzaei thefeasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT soniashpendi thefeasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT jamesbrimicombe thefeasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT jagmohanchauhan thefeasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT debibhattacharya thefeasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT felixnaughton thefeasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT wendyhardeman thefeasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT heleneborall thefeasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT mirandavanemmenis thefeasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT annadesimoni thefeasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT amrittakhar thefeasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT pankajgupta thefeasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT prashanthpatel thefeasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT ceciliamascolo thefeasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT andrewtobyprevost thefeasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT stephenmorris thefeasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT simongriffin thefeasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT richardjmcmanus thefeasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT jonathanmant thefeasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT stephensutton thefeasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT aikaterinikassavou feasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT venusmirzaei feasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT soniashpendi feasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT jamesbrimicombe feasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT jagmohanchauhan feasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT debibhattacharya feasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT felixnaughton feasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT wendyhardeman feasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT heleneborall feasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT mirandavanemmenis feasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT annadesimoni feasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT amrittakhar feasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT pankajgupta feasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT prashanthpatel feasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT ceciliamascolo feasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT andrewtobyprevost feasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT stephenmorris feasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT simongriffin feasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT richardjmcmanus feasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT jonathanmant feasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial AT stephensutton feasibilityofthepaminterventiontosupporttreatmentadherenceinpeoplewithhypertensioninprimarycarearandomisedclinicalcontrolledtrial |
| _version_ |
1718379822239973376 |