Mobile Antimicrobial Resistance Genes in Probiotics

Even though people worldwide tend to consume probiotic products for their beneficial health effects on a daily basis, recently, concerns were outlined regarding the uptake and potential intestinal colonisation of the bacteria that they carry. These bacteria are capable of executing horizontal gene t...

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Autores principales:	Adrienn Gréta Tóth, István Csabai, Maura Fiona Judge, Gergely Maróti, Ágnes Becsei, Sándor Spisák, Norbert Solymosi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	antimicrobial resistance bacteriome resistome mobilome probiotics Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/5942afe9b4f94793b54ded8dc0fc965e
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spelling	oai:doaj.org-article:5942afe9b4f94793b54ded8dc0fc965e2021-11-25T16:21:59ZMobile Antimicrobial Resistance Genes in Probiotics10.3390/antibiotics101112872079-6382https://doaj.org/article/5942afe9b4f94793b54ded8dc0fc965e2021-10-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1287https://doaj.org/toc/2079-6382Even though people worldwide tend to consume probiotic products for their beneficial health effects on a daily basis, recently, concerns were outlined regarding the uptake and potential intestinal colonisation of the bacteria that they carry. These bacteria are capable of executing horizontal gene transfer (HGT) which facilitates the movement of various genes, including antimicrobial resistance genes (ARGs), among the donor and recipient bacterial populations. Within our study, 47 shotgun sequencing datasets deriving from various probiotic samples (isolated strains and metagenomes) were bioinformatically analysed. We detected more than 70 ARGs, out of which <i>rpoB</i> mutants conferring resistance to rifampicin, <i>tet(W/N/W)</i> and potentially extended-spectrum beta-lactamase (ESBL) coding <i>TEM-116</i> were the most common. Numerous ARGs were associated with integrated mobile genetic elements, plasmids or phages promoting the HGT. Our findings raise clinical and public health concerns as the consumption of probiotic products may lead to the transfer of ARGs to human gut bacteria.Adrienn Gréta TóthIstván CsabaiMaura Fiona JudgeGergely MarótiÁgnes BecseiSándor SpisákNorbert SolymosiMDPI AGarticleantimicrobial resistancebacteriomeresistomemobilomeprobioticsTherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1287, p 1287 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antimicrobial resistance bacteriome resistome mobilome probiotics Therapeutics. Pharmacology RM1-950
spellingShingle	antimicrobial resistance bacteriome resistome mobilome probiotics Therapeutics. Pharmacology RM1-950 Adrienn Gréta Tóth István Csabai Maura Fiona Judge Gergely Maróti Ágnes Becsei Sándor Spisák Norbert Solymosi Mobile Antimicrobial Resistance Genes in Probiotics
description	Even though people worldwide tend to consume probiotic products for their beneficial health effects on a daily basis, recently, concerns were outlined regarding the uptake and potential intestinal colonisation of the bacteria that they carry. These bacteria are capable of executing horizontal gene transfer (HGT) which facilitates the movement of various genes, including antimicrobial resistance genes (ARGs), among the donor and recipient bacterial populations. Within our study, 47 shotgun sequencing datasets deriving from various probiotic samples (isolated strains and metagenomes) were bioinformatically analysed. We detected more than 70 ARGs, out of which <i>rpoB</i> mutants conferring resistance to rifampicin, <i>tet(W/N/W)</i> and potentially extended-spectrum beta-lactamase (ESBL) coding <i>TEM-116</i> were the most common. Numerous ARGs were associated with integrated mobile genetic elements, plasmids or phages promoting the HGT. Our findings raise clinical and public health concerns as the consumption of probiotic products may lead to the transfer of ARGs to human gut bacteria.
format	article
author	Adrienn Gréta Tóth István Csabai Maura Fiona Judge Gergely Maróti Ágnes Becsei Sándor Spisák Norbert Solymosi
author_facet	Adrienn Gréta Tóth István Csabai Maura Fiona Judge Gergely Maróti Ágnes Becsei Sándor Spisák Norbert Solymosi
author_sort	Adrienn Gréta Tóth
title	Mobile Antimicrobial Resistance Genes in Probiotics
title_short	Mobile Antimicrobial Resistance Genes in Probiotics
title_full	Mobile Antimicrobial Resistance Genes in Probiotics
title_fullStr	Mobile Antimicrobial Resistance Genes in Probiotics
title_full_unstemmed	Mobile Antimicrobial Resistance Genes in Probiotics
title_sort	mobile antimicrobial resistance genes in probiotics
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5942afe9b4f94793b54ded8dc0fc965e
work_keys_str_mv	AT adrienngretatoth mobileantimicrobialresistancegenesinprobiotics AT istvancsabai mobileantimicrobialresistancegenesinprobiotics AT maurafionajudge mobileantimicrobialresistancegenesinprobiotics AT gergelymaroti mobileantimicrobialresistancegenesinprobiotics AT agnesbecsei mobileantimicrobialresistancegenesinprobiotics AT sandorspisak mobileantimicrobialresistancegenesinprobiotics AT norbertsolymosi mobileantimicrobialresistancegenesinprobiotics
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Mobile Antimicrobial Resistance Genes in Probiotics

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