Prevalence and molecular characterization of glucose-6-phosphate dehydrogenase deficiency in the Lue ethnic group of northern Thailand

Abstract Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common enzyme disorders. Prevalence and variant distribution of G6PD deficiency can vary in different regions and among differing ethnic groups. To reveal the G6PD frequency and molecular characterization among the Lue e...

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Autores principales:	Suwapat Sathupak, Kamonlak Leecharoenkiat, Jatupol Kampuansai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/594621cf9c17430282a109a5f1597f5b
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spelling	oai:doaj.org-article:594621cf9c17430282a109a5f1597f5b2021-12-02T10:44:09ZPrevalence and molecular characterization of glucose-6-phosphate dehydrogenase deficiency in the Lue ethnic group of northern Thailand10.1038/s41598-021-82477-w2045-2322https://doaj.org/article/594621cf9c17430282a109a5f1597f5b2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82477-whttps://doaj.org/toc/2045-2322Abstract Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common enzyme disorders. Prevalence and variant distribution of G6PD deficiency can vary in different regions and among differing ethnic groups. To reveal the G6PD frequency and molecular characterization among the Lue ethnic group of northern Thailand, blood samples of 296 unrelated individuals collecting from 6 Lue villages were analyzed. The observed G6PD enzyme activity ranged from 0.11 to 20.60 U/g Hb. Overall, 13.51% (40/296) of the individuals were identified as having G6PD deficiency status. The prevalence in males was 14.28% (20/140), while that of females was 12.82% (20/156). The most common G6PD variants in the Lue were the Kaiping 1388G > A (5.40%) and Canton 1376G > T (6.42%) types. Observed prevalence and variant types of the G6PD gene in the Lue population are similar to that of the Tai-Kadai speaking ethnic groups in southern China, which is consistent with their historically close line of ancestry. However, the founder effect that occurred during the Lue’s transboundary migration from China to Thailand showed its impact upon different patterns of G6PD distribution among each Lue village.Suwapat SathupakKamonlak LeecharoenkiatJatupol KampuansaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Suwapat Sathupak Kamonlak Leecharoenkiat Jatupol Kampuansai Prevalence and molecular characterization of glucose-6-phosphate dehydrogenase deficiency in the Lue ethnic group of northern Thailand
description	Abstract Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common enzyme disorders. Prevalence and variant distribution of G6PD deficiency can vary in different regions and among differing ethnic groups. To reveal the G6PD frequency and molecular characterization among the Lue ethnic group of northern Thailand, blood samples of 296 unrelated individuals collecting from 6 Lue villages were analyzed. The observed G6PD enzyme activity ranged from 0.11 to 20.60 U/g Hb. Overall, 13.51% (40/296) of the individuals were identified as having G6PD deficiency status. The prevalence in males was 14.28% (20/140), while that of females was 12.82% (20/156). The most common G6PD variants in the Lue were the Kaiping 1388G > A (5.40%) and Canton 1376G > T (6.42%) types. Observed prevalence and variant types of the G6PD gene in the Lue population are similar to that of the Tai-Kadai speaking ethnic groups in southern China, which is consistent with their historically close line of ancestry. However, the founder effect that occurred during the Lue’s transboundary migration from China to Thailand showed its impact upon different patterns of G6PD distribution among each Lue village.
format	article
author	Suwapat Sathupak Kamonlak Leecharoenkiat Jatupol Kampuansai
author_facet	Suwapat Sathupak Kamonlak Leecharoenkiat Jatupol Kampuansai
author_sort	Suwapat Sathupak
title	Prevalence and molecular characterization of glucose-6-phosphate dehydrogenase deficiency in the Lue ethnic group of northern Thailand
title_short	Prevalence and molecular characterization of glucose-6-phosphate dehydrogenase deficiency in the Lue ethnic group of northern Thailand
title_full	Prevalence and molecular characterization of glucose-6-phosphate dehydrogenase deficiency in the Lue ethnic group of northern Thailand
title_fullStr	Prevalence and molecular characterization of glucose-6-phosphate dehydrogenase deficiency in the Lue ethnic group of northern Thailand
title_full_unstemmed	Prevalence and molecular characterization of glucose-6-phosphate dehydrogenase deficiency in the Lue ethnic group of northern Thailand
title_sort	prevalence and molecular characterization of glucose-6-phosphate dehydrogenase deficiency in the lue ethnic group of northern thailand
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/594621cf9c17430282a109a5f1597f5b
work_keys_str_mv	AT suwapatsathupak prevalenceandmolecularcharacterizationofglucose6phosphatedehydrogenasedeficiencyinthelueethnicgroupofnorthernthailand AT kamonlakleecharoenkiat prevalenceandmolecularcharacterizationofglucose6phosphatedehydrogenasedeficiencyinthelueethnicgroupofnorthernthailand AT jatupolkampuansai prevalenceandmolecularcharacterizationofglucose6phosphatedehydrogenasedeficiencyinthelueethnicgroupofnorthernthailand
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Prevalence and molecular characterization of glucose-6-phosphate dehydrogenase deficiency in the Lue ethnic group of northern Thailand

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