YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate

YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate

Notch signalling is a fundamental negative regulator of epidermal stemness. Here, the authors show that cell mechanics through YAP/TAZ activity prevent primary human keratinocytes from differentiating by inhibiting cell-autonomous Notch signals.

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Autores principales: Antonio Totaro, Martina Castellan, Giusy Battilana, Francesca Zanconato, Luca Azzolin, Stefano Giulitti, Michelangelo Cordenonsi, Stefano Piccolo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/594670e97aba451c8912bf09316bfecd
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spelling oai:doaj.org-article:594670e97aba451c8912bf09316bfecd2021-12-02T17:06:21ZYAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate10.1038/ncomms152062041-1723https://doaj.org/article/594670e97aba451c8912bf09316bfecd2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15206https://doaj.org/toc/2041-1723Notch signalling is a fundamental negative regulator of epidermal stemness. Here, the authors show that cell mechanics through YAP/TAZ activity prevent primary human keratinocytes from differentiating by inhibiting cell-autonomous Notch signals.Antonio TotaroMartina CastellanGiusy BattilanaFrancesca ZanconatoLuca AzzolinStefano GiulittiMichelangelo CordenonsiStefano PiccoloNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Antonio Totaro
Martina Castellan
Giusy Battilana
Francesca Zanconato
Luca Azzolin
Stefano Giulitti
Michelangelo Cordenonsi
Stefano Piccolo
YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate
description Notch signalling is a fundamental negative regulator of epidermal stemness. Here, the authors show that cell mechanics through YAP/TAZ activity prevent primary human keratinocytes from differentiating by inhibiting cell-autonomous Notch signals.
format article
author Antonio Totaro
Martina Castellan
Giusy Battilana
Francesca Zanconato
Luca Azzolin
Stefano Giulitti
Michelangelo Cordenonsi
Stefano Piccolo
author_facet Antonio Totaro
Martina Castellan
Giusy Battilana
Francesca Zanconato
Luca Azzolin
Stefano Giulitti
Michelangelo Cordenonsi
Stefano Piccolo
author_sort Antonio Totaro
title YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate
title_short YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate
title_full YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate
title_fullStr YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate
title_full_unstemmed YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate
title_sort yap/taz link cell mechanics to notch signalling to control epidermal stem cell fate
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/594670e97aba451c8912bf09316bfecd
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AT giusybattilana yaptazlinkcellmechanicstonotchsignallingtocontrolepidermalstemcellfate
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AT stefanopiccolo yaptazlinkcellmechanicstonotchsignallingtocontrolepidermalstemcellfate
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