Separating the apples from the oranges: from NAFLD heterogeneity to personalized medicine

Recently, Arrese and Colleagues have published a review article entitled, “Insights into Nonalcoholic Fatty-Liver Disease (NAFLD) Heterogeneity” (Semin Liver Dis. 2021;41:421–34. doi: 10.1055/s-0041-1730927). This milestone publication clearly and exhaustively explains the multitude of pathogenic pa...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Amedeo Lonardo
Formato:	article
Lenguaje:	EN
Publicado:	Open Exploration Publishing Inc. 2021
Materias:	clinical phenotypes diagnosis disease outcomes heterogeneity management natural course personalized medicine precision medicine variability Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/5948210b055e4d3d93a28d8e26ac6949
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5948210b055e4d3d93a28d8e26ac6949
record_format	dspace
spelling	oai:doaj.org-article:5948210b055e4d3d93a28d8e26ac69492021-11-08T09:45:06ZSeparating the apples from the oranges: from NAFLD heterogeneity to personalized medicine10.37349/emed.2021.000612692-3106https://doaj.org/article/5948210b055e4d3d93a28d8e26ac69492021-10-01T00:00:00Zhttps://www.explorationpub.com/Journals/em/Article/100161https://doaj.org/toc/2692-3106Recently, Arrese and Colleagues have published a review article entitled, “Insights into Nonalcoholic Fatty-Liver Disease (NAFLD) Heterogeneity” (Semin Liver Dis. 2021;41:421–34. doi: 10.1055/s-0041-1730927). This milestone publication clearly and exhaustively explains the multitude of pathogenic pathways involved in the development and progression of disease eventually conducive to heterogeneous clinical phenotypes and different disease outcomes. The present commentary first briefly discusses the biological grounds of NAFLD heterogeneity and then illustrates the work by Arrese et al. In conclusion, the presently adopted nomenclatures appear inadequate in rendering the complexity of disease in the individual patient. In order to adopt the principles of personalized care, what remains to be done is to propose and validate a simple and accurate classification system. This should give full consideration to the principal disease modifiers and should shape a scheme to be adopted in both clinical practice and in the research arena. Care should be taken to not neglect the systemic nature of disease.Amedeo LonardoOpen Exploration Publishing Inc.articleclinical phenotypesdiagnosisdisease outcomesheterogeneitymanagementnatural coursepersonalized medicineprecision medicinevariabilityOther systems of medicineRZ201-999ENExploration of Medicine, Vol 2, Iss 5, Pp 435-442 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	clinical phenotypes diagnosis disease outcomes heterogeneity management natural course personalized medicine precision medicine variability Other systems of medicine RZ201-999
spellingShingle	clinical phenotypes diagnosis disease outcomes heterogeneity management natural course personalized medicine precision medicine variability Other systems of medicine RZ201-999 Amedeo Lonardo Separating the apples from the oranges: from NAFLD heterogeneity to personalized medicine
description	Recently, Arrese and Colleagues have published a review article entitled, “Insights into Nonalcoholic Fatty-Liver Disease (NAFLD) Heterogeneity” (Semin Liver Dis. 2021;41:421–34. doi: 10.1055/s-0041-1730927). This milestone publication clearly and exhaustively explains the multitude of pathogenic pathways involved in the development and progression of disease eventually conducive to heterogeneous clinical phenotypes and different disease outcomes. The present commentary first briefly discusses the biological grounds of NAFLD heterogeneity and then illustrates the work by Arrese et al. In conclusion, the presently adopted nomenclatures appear inadequate in rendering the complexity of disease in the individual patient. In order to adopt the principles of personalized care, what remains to be done is to propose and validate a simple and accurate classification system. This should give full consideration to the principal disease modifiers and should shape a scheme to be adopted in both clinical practice and in the research arena. Care should be taken to not neglect the systemic nature of disease.
format	article
author	Amedeo Lonardo
author_facet	Amedeo Lonardo
author_sort	Amedeo Lonardo
title	Separating the apples from the oranges: from NAFLD heterogeneity to personalized medicine
title_short	Separating the apples from the oranges: from NAFLD heterogeneity to personalized medicine
title_full	Separating the apples from the oranges: from NAFLD heterogeneity to personalized medicine
title_fullStr	Separating the apples from the oranges: from NAFLD heterogeneity to personalized medicine
title_full_unstemmed	Separating the apples from the oranges: from NAFLD heterogeneity to personalized medicine
title_sort	separating the apples from the oranges: from nafld heterogeneity to personalized medicine
publisher	Open Exploration Publishing Inc.
publishDate	2021
url	https://doaj.org/article/5948210b055e4d3d93a28d8e26ac6949
work_keys_str_mv	AT amedeolonardo separatingtheapplesfromtheorangesfromnafldheterogeneitytopersonalizedmedicine
_version_	1718442717064724480

Separating the apples from the oranges: from NAFLD heterogeneity to personalized medicine

Ejemplares similares