HIV protease inhibitors: a review of molecular selectivity and toxicity

Zhengtong Lv,* Yuan Chu,* Yong Wang Department of Immunology, School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China *Both authors contributed equally to this work Abstract: Highly active antiretroviral therapy (...

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Autores principales:	Lv Z, Chu Y, Wang Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/5948916cbb8a4cfcb98afcb99d70ab6b
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spelling	oai:doaj.org-article:5948916cbb8a4cfcb98afcb99d70ab6b2021-12-02T03:20:11ZHIV protease inhibitors: a review of molecular selectivity and toxicity1179-1373https://doaj.org/article/5948916cbb8a4cfcb98afcb99d70ab6b2015-04-01T00:00:00Zhttp://www.dovepress.com/hiv-protease-inhibitors-a-review-of-molecular-selectivity-and-toxicity-peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373 Zhengtong Lv,* Yuan Chu,* Yong Wang Department of Immunology, School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China *Both authors contributed equally to this work Abstract: Highly active antiretroviral therapy (HAART) is recognized as the most effective treatment method for AIDS, and protease inhibitors play a very important role in HAART. However, poor bioavailability and unbearable toxicity are their common disadvantages. Thus, the development of safer and potentially promising protease inhibitors is eagerly needed. In this review, we introduced the chemical characteristics and associated side effects of HIV protease inhibitors, as well as the possible off-target mechanisms causing the side effects. From the chemical structures of HIV protease inhibitors and their possible off-target molecules, we could obtain hints for optimizing the molecular selectivity of the inhibitors, to provide help in the design of new compounds with enhanced bioavailability and reduced side effects. Keywords: off-target, side effect, glucose transporter-4, proteasomeLv ZChu YWang YDove Medical PressarticleImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol 2015, Iss default, Pp 95-104 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607
spellingShingle	Immunologic diseases. Allergy RC581-607 Lv Z Chu Y Wang Y HIV protease inhibitors: a review of molecular selectivity and toxicity
description	Zhengtong Lv,* Yuan Chu,* Yong Wang Department of Immunology, School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China *Both authors contributed equally to this work Abstract: Highly active antiretroviral therapy (HAART) is recognized as the most effective treatment method for AIDS, and protease inhibitors play a very important role in HAART. However, poor bioavailability and unbearable toxicity are their common disadvantages. Thus, the development of safer and potentially promising protease inhibitors is eagerly needed. In this review, we introduced the chemical characteristics and associated side effects of HIV protease inhibitors, as well as the possible off-target mechanisms causing the side effects. From the chemical structures of HIV protease inhibitors and their possible off-target molecules, we could obtain hints for optimizing the molecular selectivity of the inhibitors, to provide help in the design of new compounds with enhanced bioavailability and reduced side effects. Keywords: off-target, side effect, glucose transporter-4, proteasome
format	article
author	Lv Z Chu Y Wang Y
author_facet	Lv Z Chu Y Wang Y
author_sort	Lv Z
title	HIV protease inhibitors: a review of molecular selectivity and toxicity
title_short	HIV protease inhibitors: a review of molecular selectivity and toxicity
title_full	HIV protease inhibitors: a review of molecular selectivity and toxicity
title_fullStr	HIV protease inhibitors: a review of molecular selectivity and toxicity
title_full_unstemmed	HIV protease inhibitors: a review of molecular selectivity and toxicity
title_sort	hiv protease inhibitors: a review of molecular selectivity and toxicity
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/5948916cbb8a4cfcb98afcb99d70ab6b
work_keys_str_mv	AT lvz hivproteaseinhibitorsareviewofmolecularselectivityandtoxicity AT chuy hivproteaseinhibitorsareviewofmolecularselectivityandtoxicity AT wangy hivproteaseinhibitorsareviewofmolecularselectivityandtoxicity
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HIV protease inhibitors: a review of molecular selectivity and toxicity

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