Topical treatment options for conjunctival neoplasms

Jonathan W Kim, David H AbramsonOphthalmic Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USAAbstract: Topical therapies offer a nonsurgical method for treating conjunctival tumors by delivering high drug concentrations to the ocular surface. Over the past ten years, topical...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jonathan W Kim, David H Abramson
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/5949346dd17041ff9b545f6609308874
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5949346dd17041ff9b545f6609308874
record_format	dspace
spelling	oai:doaj.org-article:5949346dd17041ff9b545f66093088742021-12-02T06:49:40ZTopical treatment options for conjunctival neoplasms1177-54671177-5483https://doaj.org/article/5949346dd17041ff9b545f66093088742008-10-01T00:00:00Zhttp://www.dovepress.com/topical-treatment-options-for-conjunctival-neoplasms-a2355https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Jonathan W Kim, David H AbramsonOphthalmic Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USAAbstract: Topical therapies offer a nonsurgical method for treating conjunctival tumors by delivering high drug concentrations to the ocular surface. Over the past ten years, topical agents have been used by investigators to treat various premalignant and malignant lesions of the conjunctiva, such as primary acquired melanosis with atypia, conjunctival melanoma, squamous intraepithelial neoplasia and squamous cell carcinoma of the conjunctiva, and pagetoid spread of the conjunctiva arising from sebaceous cell carcinoma. Despite the enthusiasm generated by the success of these agents, there are unanswered questions regarding the clinical efficacy of this new nonsurgical approach, and whether a single topical agent can achieve cure rates comparable with traditional therapies. Furthermore, the long-term consequences of prolonged courses of topical chemotherapeutic drugs on the ocular surface are unknown, and the ideal regimen for each of these agents is still being refined. In this review, we present specific guidelines for treating both melanocytic and squamous neoplasms of the conjunctiva, utilizing the available data in the literature as well as our own clinical experience at the Memorial Sloan-Kettering Cancer Center.Keywords: topical therapies, conjunctival neoplasms melanosis, Mitomycin-C, 5-Fluorouracil Jonathan W KimDavid H AbramsonDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2008, Iss Issue 3, Pp 503-515 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Jonathan W Kim David H Abramson Topical treatment options for conjunctival neoplasms
description	Jonathan W Kim, David H AbramsonOphthalmic Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USAAbstract: Topical therapies offer a nonsurgical method for treating conjunctival tumors by delivering high drug concentrations to the ocular surface. Over the past ten years, topical agents have been used by investigators to treat various premalignant and malignant lesions of the conjunctiva, such as primary acquired melanosis with atypia, conjunctival melanoma, squamous intraepithelial neoplasia and squamous cell carcinoma of the conjunctiva, and pagetoid spread of the conjunctiva arising from sebaceous cell carcinoma. Despite the enthusiasm generated by the success of these agents, there are unanswered questions regarding the clinical efficacy of this new nonsurgical approach, and whether a single topical agent can achieve cure rates comparable with traditional therapies. Furthermore, the long-term consequences of prolonged courses of topical chemotherapeutic drugs on the ocular surface are unknown, and the ideal regimen for each of these agents is still being refined. In this review, we present specific guidelines for treating both melanocytic and squamous neoplasms of the conjunctiva, utilizing the available data in the literature as well as our own clinical experience at the Memorial Sloan-Kettering Cancer Center.Keywords: topical therapies, conjunctival neoplasms melanosis, Mitomycin-C, 5-Fluorouracil
format	article
author	Jonathan W Kim David H Abramson
author_facet	Jonathan W Kim David H Abramson
author_sort	Jonathan W Kim
title	Topical treatment options for conjunctival neoplasms
title_short	Topical treatment options for conjunctival neoplasms
title_full	Topical treatment options for conjunctival neoplasms
title_fullStr	Topical treatment options for conjunctival neoplasms
title_full_unstemmed	Topical treatment options for conjunctival neoplasms
title_sort	topical treatment options for conjunctival neoplasms
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/5949346dd17041ff9b545f6609308874
work_keys_str_mv	AT jonathanwkim topicaltreatmentoptionsforconjunctivalneoplasms AT davidhabramson topicaltreatmentoptionsforconjunctivalneoplasms
_version_	1718399691701354496

Topical treatment options for conjunctival neoplasms

Ejemplares similares