Electrode montage-dependent intracranial variability in electric fields induced by cerebellar transcranial direct current stimulation

Abstract Transcranial direct current stimulation (tDCS) is an increasingly popular tool to investigate the involvement of the cerebellum in a variety of brain functions and pathologies. However, heterogeneity and small effect sizes remain a common issue. One potential cause may be interindividual va...

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Autores principales:	Jana Klaus, Dennis J. L. G. Schutter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/594a724da6f0427ba9a62d00380a24ba
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spelling	oai:doaj.org-article:594a724da6f0427ba9a62d00380a24ba2021-11-14T12:24:13ZElectrode montage-dependent intracranial variability in electric fields induced by cerebellar transcranial direct current stimulation10.1038/s41598-021-01755-92045-2322https://doaj.org/article/594a724da6f0427ba9a62d00380a24ba2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01755-9https://doaj.org/toc/2045-2322Abstract Transcranial direct current stimulation (tDCS) is an increasingly popular tool to investigate the involvement of the cerebellum in a variety of brain functions and pathologies. However, heterogeneity and small effect sizes remain a common issue. One potential cause may be interindividual variability of the electric fields induced by tDCS. Here, we compared electric field distributions and directions between two conventionally used electrode montages (i.e., one placing the return electrode over the ipsilateral buccinator muscle and one placing the return electrode [25 and 35 cm2 surface area, respectively] over the contralateral supraorbital area; Experiment 1) and six alternative montages (electrode size: 9 cm2; Experiment 2) targeting the right posterior cerebellar hemisphere at 2 mA. Interindividual and montage differences in the achieved maximum field strength, focality, and direction of current flow were evaluated in 20 head models and the effects of individual differences in scalp–cortex distance were examined. Results showed that while maximum field strength was comparable for all montages, focality was substantially improved for the alternative montages over inferior occipital positions. Our findings suggest that compared to several conventional montages extracerebellar electric fields are significantly reduced by placing smaller electrodes in closer vicinity of the targeted area.Jana KlausDennis J. L. G. SchutterNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jana Klaus Dennis J. L. G. Schutter Electrode montage-dependent intracranial variability in electric fields induced by cerebellar transcranial direct current stimulation
description	Abstract Transcranial direct current stimulation (tDCS) is an increasingly popular tool to investigate the involvement of the cerebellum in a variety of brain functions and pathologies. However, heterogeneity and small effect sizes remain a common issue. One potential cause may be interindividual variability of the electric fields induced by tDCS. Here, we compared electric field distributions and directions between two conventionally used electrode montages (i.e., one placing the return electrode over the ipsilateral buccinator muscle and one placing the return electrode [25 and 35 cm2 surface area, respectively] over the contralateral supraorbital area; Experiment 1) and six alternative montages (electrode size: 9 cm2; Experiment 2) targeting the right posterior cerebellar hemisphere at 2 mA. Interindividual and montage differences in the achieved maximum field strength, focality, and direction of current flow were evaluated in 20 head models and the effects of individual differences in scalp–cortex distance were examined. Results showed that while maximum field strength was comparable for all montages, focality was substantially improved for the alternative montages over inferior occipital positions. Our findings suggest that compared to several conventional montages extracerebellar electric fields are significantly reduced by placing smaller electrodes in closer vicinity of the targeted area.
format	article
author	Jana Klaus Dennis J. L. G. Schutter
author_facet	Jana Klaus Dennis J. L. G. Schutter
author_sort	Jana Klaus
title	Electrode montage-dependent intracranial variability in electric fields induced by cerebellar transcranial direct current stimulation
title_short	Electrode montage-dependent intracranial variability in electric fields induced by cerebellar transcranial direct current stimulation
title_full	Electrode montage-dependent intracranial variability in electric fields induced by cerebellar transcranial direct current stimulation
title_fullStr	Electrode montage-dependent intracranial variability in electric fields induced by cerebellar transcranial direct current stimulation
title_full_unstemmed	Electrode montage-dependent intracranial variability in electric fields induced by cerebellar transcranial direct current stimulation
title_sort	electrode montage-dependent intracranial variability in electric fields induced by cerebellar transcranial direct current stimulation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/594a724da6f0427ba9a62d00380a24ba
work_keys_str_mv	AT janaklaus electrodemontagedependentintracranialvariabilityinelectricfieldsinducedbycerebellartranscranialdirectcurrentstimulation AT dennisjlgschutter electrodemontagedependentintracranialvariabilityinelectricfieldsinducedbycerebellartranscranialdirectcurrentstimulation
_version_	1718429226966712320

Electrode montage-dependent intracranial variability in electric fields induced by cerebellar transcranial direct current stimulation

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