Allogeneic stem cell transplantation in fully MHC-matched Mauritian cynomolgus macaques recapitulates diverse human clinical outcomes

Allogeneic stem cell transplantation in fully MHC-matched Mauritian cynomolgus macaques recapitulates diverse human clinical outcomes

Rhesus macaques are not ideal for studying response to allogeneic hematopoietic stem cell transplant (allo-HSCT) owing to complex MHC genetics that prevent full MHC-matching. Here the authors show that inbred Mauritian-origin cynomolgus macaques are a superior preclinical model of allogeneic stem ce...

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Autores principales: Benjamin J. Burwitz, Helen L. Wu, Shaheed Abdulhaqq, Christine Shriver-Munsch, Tonya Swanson, Alfred W. Legasse, Katherine B. Hammond, Stephanie L. Junell, Jason S. Reed, Benjamin N. Bimber, Justin M. Greene, Gabriela M. Webb, Mina Northrup, Wolfram Laub, Paul Kievit, Rhonda MacAllister, Michael K. Axthelm, Rebecca Ducore, Anne Lewis, Lois M. A. Colgin, Theodore Hobbs, Lauren D. Martin, Betsy Ferguson, Charles R. Thomas Jr., Angela Panoskaltsis-Mortari, Gabrielle Meyers, Jeffrey J. Stanton, Richard T. Maziarz, Jonah B. Sacha
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/594cf734e0da46758b10c7677bcfd4af
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spelling oai:doaj.org-article:594cf734e0da46758b10c7677bcfd4af2021-12-02T15:38:39ZAllogeneic stem cell transplantation in fully MHC-matched Mauritian cynomolgus macaques recapitulates diverse human clinical outcomes10.1038/s41467-017-01631-z2041-1723https://doaj.org/article/594cf734e0da46758b10c7677bcfd4af2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01631-zhttps://doaj.org/toc/2041-1723Rhesus macaques are not ideal for studying response to allogeneic hematopoietic stem cell transplant (allo-HSCT) owing to complex MHC genetics that prevent full MHC-matching. Here the authors show that inbred Mauritian-origin cynomolgus macaques are a superior preclinical model of allogeneic stem cell transplantation that mimics diverse clinical outcomes of human allo-HSCT.Benjamin J. BurwitzHelen L. WuShaheed AbdulhaqqChristine Shriver-MunschTonya SwansonAlfred W. LegasseKatherine B. HammondStephanie L. JunellJason S. ReedBenjamin N. BimberJustin M. GreeneGabriela M. WebbMina NorthrupWolfram LaubPaul KievitRhonda MacAllisterMichael K. AxthelmRebecca DucoreAnne LewisLois M. A. ColginTheodore HobbsLauren D. MartinBetsy FergusonCharles R. Thomas Jr.Angela Panoskaltsis-MortariGabrielle MeyersJeffrey J. StantonRichard T. MaziarzJonah B. SachaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Benjamin J. Burwitz
Helen L. Wu
Shaheed Abdulhaqq
Christine Shriver-Munsch
Tonya Swanson
Alfred W. Legasse
Katherine B. Hammond
Stephanie L. Junell
Jason S. Reed
Benjamin N. Bimber
Justin M. Greene
Gabriela M. Webb
Mina Northrup
Wolfram Laub
Paul Kievit
Rhonda MacAllister
Michael K. Axthelm
Rebecca Ducore
Anne Lewis
Lois M. A. Colgin
Theodore Hobbs
Lauren D. Martin
Betsy Ferguson
Charles R. Thomas Jr.
Angela Panoskaltsis-Mortari
Gabrielle Meyers
Jeffrey J. Stanton
Richard T. Maziarz
Jonah B. Sacha
Allogeneic stem cell transplantation in fully MHC-matched Mauritian cynomolgus macaques recapitulates diverse human clinical outcomes
description Rhesus macaques are not ideal for studying response to allogeneic hematopoietic stem cell transplant (allo-HSCT) owing to complex MHC genetics that prevent full MHC-matching. Here the authors show that inbred Mauritian-origin cynomolgus macaques are a superior preclinical model of allogeneic stem cell transplantation that mimics diverse clinical outcomes of human allo-HSCT.
format article
author Benjamin J. Burwitz
Helen L. Wu
Shaheed Abdulhaqq
Christine Shriver-Munsch
Tonya Swanson
Alfred W. Legasse
Katherine B. Hammond
Stephanie L. Junell
Jason S. Reed
Benjamin N. Bimber
Justin M. Greene
Gabriela M. Webb
Mina Northrup
Wolfram Laub
Paul Kievit
Rhonda MacAllister
Michael K. Axthelm
Rebecca Ducore
Anne Lewis
Lois M. A. Colgin
Theodore Hobbs
Lauren D. Martin
Betsy Ferguson
Charles R. Thomas Jr.
Angela Panoskaltsis-Mortari
Gabrielle Meyers
Jeffrey J. Stanton
Richard T. Maziarz
Jonah B. Sacha
author_facet Benjamin J. Burwitz
Helen L. Wu
Shaheed Abdulhaqq
Christine Shriver-Munsch
Tonya Swanson
Alfred W. Legasse
Katherine B. Hammond
Stephanie L. Junell
Jason S. Reed
Benjamin N. Bimber
Justin M. Greene
Gabriela M. Webb
Mina Northrup
Wolfram Laub
Paul Kievit
Rhonda MacAllister
Michael K. Axthelm
Rebecca Ducore
Anne Lewis
Lois M. A. Colgin
Theodore Hobbs
Lauren D. Martin
Betsy Ferguson
Charles R. Thomas Jr.
Angela Panoskaltsis-Mortari
Gabrielle Meyers
Jeffrey J. Stanton
Richard T. Maziarz
Jonah B. Sacha
author_sort Benjamin J. Burwitz
title Allogeneic stem cell transplantation in fully MHC-matched Mauritian cynomolgus macaques recapitulates diverse human clinical outcomes
title_short Allogeneic stem cell transplantation in fully MHC-matched Mauritian cynomolgus macaques recapitulates diverse human clinical outcomes
title_full Allogeneic stem cell transplantation in fully MHC-matched Mauritian cynomolgus macaques recapitulates diverse human clinical outcomes
title_fullStr Allogeneic stem cell transplantation in fully MHC-matched Mauritian cynomolgus macaques recapitulates diverse human clinical outcomes
title_full_unstemmed Allogeneic stem cell transplantation in fully MHC-matched Mauritian cynomolgus macaques recapitulates diverse human clinical outcomes
title_sort allogeneic stem cell transplantation in fully mhc-matched mauritian cynomolgus macaques recapitulates diverse human clinical outcomes
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/594cf734e0da46758b10c7677bcfd4af
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