Synthesis of tetrazolo[1,5-a]pyrimidine-6-carbonitriles using HMTA-BAIL@MIL-101(Cr) as a superior heterogeneous catalyst

Abstract A one-pot three component reaction of benzaldehydes, 1H-tetrazole-5-amine, and 3-cyanoacetyl indole in the presence of a new hexamethylenetetramine-based ionic liquid/MIL-101(Cr) metal–organic framework as a recyclable catalyst was explored. This novel catalyst, which was fully characterize...

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Autores principales:	Mohammad Hossein Abdollahi-Basir, Boshra Mirhosseini-Eshkevari, Farzad Zamani, Mohammad Ali Ghasemzadeh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/594cf8572fa9484fbc0b9e3359d41274
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spelling	oai:doaj.org-article:594cf8572fa9484fbc0b9e3359d412742021-12-02T13:30:51ZSynthesis of tetrazolo[1,5-a]pyrimidine-6-carbonitriles using HMTA-BAIL@MIL-101(Cr) as a superior heterogeneous catalyst10.1038/s41598-021-84379-32045-2322https://doaj.org/article/594cf8572fa9484fbc0b9e3359d412742021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84379-3https://doaj.org/toc/2045-2322Abstract A one-pot three component reaction of benzaldehydes, 1H-tetrazole-5-amine, and 3-cyanoacetyl indole in the presence of a new hexamethylenetetramine-based ionic liquid/MIL-101(Cr) metal–organic framework as a recyclable catalyst was explored. This novel catalyst, which was fully characterized by XRD, FE-SEM, EDX, FT-IR, TGA, BET, and TEM exhibited outstanding catalytic activity for the preparation of a range of pharmaceutically important tetrazolo[1,5-a]pyrimidine-6-carbonitriles with good to excellent yields in short reaction time.Mohammad Hossein Abdollahi-BasirBoshra Mirhosseini-EshkevariFarzad ZamaniMohammad Ali GhasemzadehNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mohammad Hossein Abdollahi-Basir Boshra Mirhosseini-Eshkevari Farzad Zamani Mohammad Ali Ghasemzadeh Synthesis of tetrazolo[1,5-a]pyrimidine-6-carbonitriles using HMTA-BAIL@MIL-101(Cr) as a superior heterogeneous catalyst
description	Abstract A one-pot three component reaction of benzaldehydes, 1H-tetrazole-5-amine, and 3-cyanoacetyl indole in the presence of a new hexamethylenetetramine-based ionic liquid/MIL-101(Cr) metal–organic framework as a recyclable catalyst was explored. This novel catalyst, which was fully characterized by XRD, FE-SEM, EDX, FT-IR, TGA, BET, and TEM exhibited outstanding catalytic activity for the preparation of a range of pharmaceutically important tetrazolo[1,5-a]pyrimidine-6-carbonitriles with good to excellent yields in short reaction time.
format	article
author	Mohammad Hossein Abdollahi-Basir Boshra Mirhosseini-Eshkevari Farzad Zamani Mohammad Ali Ghasemzadeh
author_facet	Mohammad Hossein Abdollahi-Basir Boshra Mirhosseini-Eshkevari Farzad Zamani Mohammad Ali Ghasemzadeh
author_sort	Mohammad Hossein Abdollahi-Basir
title	Synthesis of tetrazolo[1,5-a]pyrimidine-6-carbonitriles using HMTA-BAIL@MIL-101(Cr) as a superior heterogeneous catalyst
title_short	Synthesis of tetrazolo[1,5-a]pyrimidine-6-carbonitriles using HMTA-BAIL@MIL-101(Cr) as a superior heterogeneous catalyst
title_full	Synthesis of tetrazolo[1,5-a]pyrimidine-6-carbonitriles using HMTA-BAIL@MIL-101(Cr) as a superior heterogeneous catalyst
title_fullStr	Synthesis of tetrazolo[1,5-a]pyrimidine-6-carbonitriles using HMTA-BAIL@MIL-101(Cr) as a superior heterogeneous catalyst
title_full_unstemmed	Synthesis of tetrazolo[1,5-a]pyrimidine-6-carbonitriles using HMTA-BAIL@MIL-101(Cr) as a superior heterogeneous catalyst
title_sort	synthesis of tetrazolo[1,5-a]pyrimidine-6-carbonitriles using hmta-bail@mil-101(cr) as a superior heterogeneous catalyst
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/594cf8572fa9484fbc0b9e3359d41274
work_keys_str_mv	AT mohammadhosseinabdollahibasir synthesisoftetrazolo15apyrimidine6carbonitrilesusinghmtabailmil101crasasuperiorheterogeneouscatalyst AT boshramirhosseinieshkevari synthesisoftetrazolo15apyrimidine6carbonitrilesusinghmtabailmil101crasasuperiorheterogeneouscatalyst AT farzadzamani synthesisoftetrazolo15apyrimidine6carbonitrilesusinghmtabailmil101crasasuperiorheterogeneouscatalyst AT mohammadalighasemzadeh synthesisoftetrazolo15apyrimidine6carbonitrilesusinghmtabailmil101crasasuperiorheterogeneouscatalyst
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Synthesis of tetrazolo[1,5-a]pyrimidine-6-carbonitriles using HMTA-BAIL@MIL-101(Cr) as a superior heterogeneous catalyst

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