A Radio-Nano-Platform for T1/T2 Dual-Mode PET-MR Imaging

Yaser Hadi Gholami, 1–3 Hushan Yuan, 4 Moses Q Wilks, 4 Richard Maschmeyer, 1 Marc D Normandin, 4 Lee Josephson, 4 Georges El Fakhri, 4 Zdenka Kuncic 1, 2, 5  1Faculty of Science, School of Physics, The University of Sydney, Sydney, NSW, Australia; 2Sydney Vital Translational Can...

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Autores principales:	Gholami YH, Yuan H, Wilks MQ, Maschmeyer R, Normandin MD, Josephson L, El Fakhri G, Kuncic Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	spions hir radiolabeling mri pet multimodal imaging. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/594f6852d2cd4928b1b0fcdfa5648fba
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spelling	oai:doaj.org-article:594f6852d2cd4928b1b0fcdfa5648fba2021-12-02T05:07:41ZA Radio-Nano-Platform for T1/T2 Dual-Mode PET-MR Imaging1178-2013https://doaj.org/article/594f6852d2cd4928b1b0fcdfa5648fba2020-02-01T00:00:00Zhttps://www.dovepress.com/a-radio-nano-platform-for-t1t2-dual-mode-pet-mr-imaging-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yaser Hadi Gholami, 1–3 Hushan Yuan, 4 Moses Q Wilks, 4 Richard Maschmeyer, 1 Marc D Normandin, 4 Lee Josephson, 4 Georges El Fakhri, 4 Zdenka Kuncic 1, 2, 5  1Faculty of Science, School of Physics, The University of Sydney, Sydney, NSW, Australia; 2Sydney Vital Translational Cancer Research Centre, St Leonards, NSW, Australia; 3Bill Walsh Translational Cancer Research Laboratory, The Kolling Institute, Northern Sydney Local Health District, Sydney, NSW, Australia; 4Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; 5The University of Sydney Nano Institute, Sydney, NSW, AustraliaCorrespondence: Zdenka Kuncic; Yaser Hadi GholamiSchool of Physics A28, The University of Sydney, Sydney, NSW 2006, AustraliaTel +61 2 9351 3162Fax +61 2 9351 7726Email zdenka.kuncic@sydney.edu.au; yaser.gholami@sydney.edu.auPurpose: This study aimed to develop a chelate-free radiolabeled nanoparticle platform for simultaneous positron emission tomography (PET) and magnetic resonance (MR) imaging that provides contrast-enhanced diagnostic imaging and significant image quality gain by integrating the high spatial resolution of MR with the high sensitivity of PET.Methods: A commercially available super-paramagnetic iron oxide nanoparticle (SPION) (Feraheme®, FH) was labeled with the [ 89Zr]Zr using a novel chelate-free radiolabeling technique, heat-induced radiolabeling (HIR). Radiochemical yield (RCY) and purity (RCP) were measured using size exclusion chromatography (SEC) and radio-thin layer chromatography (radio-TLC). Characterization of the non-radioactive isotope 90Zr-labeled FH was performed by transmission electron microscopy (TEM). Simultaneous PET-MR phantom imaging was performed with different 89Zr-FH concentrations. The MR quantitative image analysis determined the contrast-enhancing properties of FH. The signal-to-noise ratio (SNR) and full-width half-maximum (FWHM) of the line spread function (LSF) were calculated before and after co-registering the PET and MR image data.Results: High RCY (92%) and RCP (98%) of the [ 89Zr]Zr-FH product was achieved. TEM analysis confirmed the 90Zr atoms adsorption onto the SPION surface (≈ 10% average radial increase). Simultaneous PET-MR scans confirmed the capability of the [ 89Zr]Zr-FH nano-platform for this multi-modal imaging technique. Relative contrast image analysis showed that [ 89Zr]Zr-FH can act as a dual-mode T1/T2 contrast agent. For co-registered PET-MR images, higher spatial resolution (FWHM enhancement ≈ 3) and SNR (enhancement ≈ 8) was achieved at a clinical dose of radio-isotope and Fe.Conclusion: Our results demonstrate FH is a highly suitable SPION-based platform for chelate-free labeling of PET tracers for hybrid PET-MR. The high RCY and RCP confirmed the robustness of the chelate-free HIR technique. An overall image quality gain was achieved compared to PET- or MR-alone imaging with a relatively low dosage of [ 89Zr]Zr-FH. Additionally, FH is suitable as a dual-mode T1/T2 MR image contrast agent.Keywords: SPIONs, HIR, radiolabeling, MRI, PET, multimodal imagingGholami YHYuan HWilks MQMaschmeyer RNormandin MDJosephson LEl Fakhri GKuncic ZDove Medical Pressarticlespionshirradiolabelingmripetmultimodal imaging.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 1253-1266 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	spions hir radiolabeling mri pet multimodal imaging. Medicine (General) R5-920
spellingShingle	spions hir radiolabeling mri pet multimodal imaging. Medicine (General) R5-920 Gholami YH Yuan H Wilks MQ Maschmeyer R Normandin MD Josephson L El Fakhri G Kuncic Z A Radio-Nano-Platform for T1/T2 Dual-Mode PET-MR Imaging
description	Yaser Hadi Gholami, 1–3 Hushan Yuan, 4 Moses Q Wilks, 4 Richard Maschmeyer, 1 Marc D Normandin, 4 Lee Josephson, 4 Georges El Fakhri, 4 Zdenka Kuncic 1, 2, 5  1Faculty of Science, School of Physics, The University of Sydney, Sydney, NSW, Australia; 2Sydney Vital Translational Cancer Research Centre, St Leonards, NSW, Australia; 3Bill Walsh Translational Cancer Research Laboratory, The Kolling Institute, Northern Sydney Local Health District, Sydney, NSW, Australia; 4Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; 5The University of Sydney Nano Institute, Sydney, NSW, AustraliaCorrespondence: Zdenka Kuncic; Yaser Hadi GholamiSchool of Physics A28, The University of Sydney, Sydney, NSW 2006, AustraliaTel +61 2 9351 3162Fax +61 2 9351 7726Email zdenka.kuncic@sydney.edu.au; yaser.gholami@sydney.edu.auPurpose: This study aimed to develop a chelate-free radiolabeled nanoparticle platform for simultaneous positron emission tomography (PET) and magnetic resonance (MR) imaging that provides contrast-enhanced diagnostic imaging and significant image quality gain by integrating the high spatial resolution of MR with the high sensitivity of PET.Methods: A commercially available super-paramagnetic iron oxide nanoparticle (SPION) (Feraheme®, FH) was labeled with the [ 89Zr]Zr using a novel chelate-free radiolabeling technique, heat-induced radiolabeling (HIR). Radiochemical yield (RCY) and purity (RCP) were measured using size exclusion chromatography (SEC) and radio-thin layer chromatography (radio-TLC). Characterization of the non-radioactive isotope 90Zr-labeled FH was performed by transmission electron microscopy (TEM). Simultaneous PET-MR phantom imaging was performed with different 89Zr-FH concentrations. The MR quantitative image analysis determined the contrast-enhancing properties of FH. The signal-to-noise ratio (SNR) and full-width half-maximum (FWHM) of the line spread function (LSF) were calculated before and after co-registering the PET and MR image data.Results: High RCY (92%) and RCP (98%) of the [ 89Zr]Zr-FH product was achieved. TEM analysis confirmed the 90Zr atoms adsorption onto the SPION surface (≈ 10% average radial increase). Simultaneous PET-MR scans confirmed the capability of the [ 89Zr]Zr-FH nano-platform for this multi-modal imaging technique. Relative contrast image analysis showed that [ 89Zr]Zr-FH can act as a dual-mode T1/T2 contrast agent. For co-registered PET-MR images, higher spatial resolution (FWHM enhancement ≈ 3) and SNR (enhancement ≈ 8) was achieved at a clinical dose of radio-isotope and Fe.Conclusion: Our results demonstrate FH is a highly suitable SPION-based platform for chelate-free labeling of PET tracers for hybrid PET-MR. The high RCY and RCP confirmed the robustness of the chelate-free HIR technique. An overall image quality gain was achieved compared to PET- or MR-alone imaging with a relatively low dosage of [ 89Zr]Zr-FH. Additionally, FH is suitable as a dual-mode T1/T2 MR image contrast agent.Keywords: SPIONs, HIR, radiolabeling, MRI, PET, multimodal imaging
format	article
author	Gholami YH Yuan H Wilks MQ Maschmeyer R Normandin MD Josephson L El Fakhri G Kuncic Z
author_facet	Gholami YH Yuan H Wilks MQ Maschmeyer R Normandin MD Josephson L El Fakhri G Kuncic Z
author_sort	Gholami YH
title	A Radio-Nano-Platform for T1/T2 Dual-Mode PET-MR Imaging
title_short	A Radio-Nano-Platform for T1/T2 Dual-Mode PET-MR Imaging
title_full	A Radio-Nano-Platform for T1/T2 Dual-Mode PET-MR Imaging
title_fullStr	A Radio-Nano-Platform for T1/T2 Dual-Mode PET-MR Imaging
title_full_unstemmed	A Radio-Nano-Platform for T1/T2 Dual-Mode PET-MR Imaging
title_sort	radio-nano-platform for t1/t2 dual-mode pet-mr imaging
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/594f6852d2cd4928b1b0fcdfa5648fba
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A Radio-Nano-Platform for T1/T2 Dual-Mode PET-MR Imaging

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