A Comprehensive Review about the Molecular Structure of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Insights into Natural Products against COVID-19

In 2019, the world suffered from the emergence of COVID-19 infection, one of the most difficult pandemics in recent history. Millions of confirmed deaths from this pandemic have been reported worldwide. This disaster was caused by SARS-CoV-2, which is the last discovered member of the family of <...

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Autores principales:	Essa M. Saied, Yousra A. El-Maradny, Alaa A. Osman, Amira M. G. Darwish, Hebatallah H. Abo Nahas, Gniewko Niedbała, Magdalena Piekutowska, Mohamed A. Abdel-Rahman, Bassem A. Balbool, Ahmed M. Abdel-Azeem
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	coronavirus SARS-CoV-2 virus lifecycle COVID-19 virus detection molecular structure Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/5951a7b0cbfb4fb89be2d248ade61312
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spelling	oai:doaj.org-article:5951a7b0cbfb4fb89be2d248ade613122021-11-25T18:40:26ZA Comprehensive Review about the Molecular Structure of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Insights into Natural Products against COVID-1910.3390/pharmaceutics131117591999-4923https://doaj.org/article/5951a7b0cbfb4fb89be2d248ade613122021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1759https://doaj.org/toc/1999-4923In 2019, the world suffered from the emergence of COVID-19 infection, one of the most difficult pandemics in recent history. Millions of confirmed deaths from this pandemic have been reported worldwide. This disaster was caused by SARS-CoV-2, which is the last discovered member of the family of <i>Coronaviridae</i>. Various studies have shown that natural compounds have effective antiviral properties against coronaviruses by inhibiting multiple viral targets, including spike proteins and viral enzymes. This review presents the classification and a detailed explanation of the SARS-CoV-2 molecular characteristics and structure–function relationships. We present all currently available crystal structures of different SARS-CoV-2 proteins and emphasized on the crystal structure of different virus proteins and the binding modes of their ligands. This review also discusses the various therapeutic approaches for COVID-19 treatment and available vaccinations. In addition, we highlight and compare the existing data about natural compounds extracted from algae, fungi, plants, and scorpion venom that were used as antiviral agents against SARS-CoV-2 infection. Moreover, we discuss the repurposing of select approved therapeutic agents that have been used in the treatment of other viruses.Essa M. SaiedYousra A. El-MaradnyAlaa A. OsmanAmira M. G. DarwishHebatallah H. Abo NahasGniewko NiedbałaMagdalena PiekutowskaMohamed A. Abdel-RahmanBassem A. BalboolAhmed M. Abdel-AzeemMDPI AGarticlecoronavirusSARS-CoV-2virus lifecycleCOVID-19virus detectionmolecular structurePharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1759, p 1759 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	coronavirus SARS-CoV-2 virus lifecycle COVID-19 virus detection molecular structure Pharmacy and materia medica RS1-441
spellingShingle	coronavirus SARS-CoV-2 virus lifecycle COVID-19 virus detection molecular structure Pharmacy and materia medica RS1-441 Essa M. Saied Yousra A. El-Maradny Alaa A. Osman Amira M. G. Darwish Hebatallah H. Abo Nahas Gniewko Niedbała Magdalena Piekutowska Mohamed A. Abdel-Rahman Bassem A. Balbool Ahmed M. Abdel-Azeem A Comprehensive Review about the Molecular Structure of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Insights into Natural Products against COVID-19
description	In 2019, the world suffered from the emergence of COVID-19 infection, one of the most difficult pandemics in recent history. Millions of confirmed deaths from this pandemic have been reported worldwide. This disaster was caused by SARS-CoV-2, which is the last discovered member of the family of <i>Coronaviridae</i>. Various studies have shown that natural compounds have effective antiviral properties against coronaviruses by inhibiting multiple viral targets, including spike proteins and viral enzymes. This review presents the classification and a detailed explanation of the SARS-CoV-2 molecular characteristics and structure–function relationships. We present all currently available crystal structures of different SARS-CoV-2 proteins and emphasized on the crystal structure of different virus proteins and the binding modes of their ligands. This review also discusses the various therapeutic approaches for COVID-19 treatment and available vaccinations. In addition, we highlight and compare the existing data about natural compounds extracted from algae, fungi, plants, and scorpion venom that were used as antiviral agents against SARS-CoV-2 infection. Moreover, we discuss the repurposing of select approved therapeutic agents that have been used in the treatment of other viruses.
format	article
author	Essa M. Saied Yousra A. El-Maradny Alaa A. Osman Amira M. G. Darwish Hebatallah H. Abo Nahas Gniewko Niedbała Magdalena Piekutowska Mohamed A. Abdel-Rahman Bassem A. Balbool Ahmed M. Abdel-Azeem
author_facet	Essa M. Saied Yousra A. El-Maradny Alaa A. Osman Amira M. G. Darwish Hebatallah H. Abo Nahas Gniewko Niedbała Magdalena Piekutowska Mohamed A. Abdel-Rahman Bassem A. Balbool Ahmed M. Abdel-Azeem
author_sort	Essa M. Saied
title	A Comprehensive Review about the Molecular Structure of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Insights into Natural Products against COVID-19
title_short	A Comprehensive Review about the Molecular Structure of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Insights into Natural Products against COVID-19
title_full	A Comprehensive Review about the Molecular Structure of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Insights into Natural Products against COVID-19
title_fullStr	A Comprehensive Review about the Molecular Structure of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Insights into Natural Products against COVID-19
title_full_unstemmed	A Comprehensive Review about the Molecular Structure of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Insights into Natural Products against COVID-19
title_sort	comprehensive review about the molecular structure of severe acute respiratory syndrome coronavirus 2 (sars-cov-2): insights into natural products against covid-19
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5951a7b0cbfb4fb89be2d248ade61312
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A Comprehensive Review about the Molecular Structure of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Insights into Natural Products against COVID-19

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