Capping gold nanoparticles with albumin to improve their biomedical properties

Karen Bolaños,1–3 Marcelo J Kogan,2,3 Eyleen Araya1,21Departamento de Ciencias Quimicas, Facultad de Ciencias Exactas, Universidad Andres Bello, Santiago, Chile; 2Departamento de Quimica Farmacologica y Toxicologica, Facultad de Ciencias Químicas y Farmacéu...

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Autores principales:	Bolaños K, Kogan MJ, Araya E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Albumin drug delivery photothermal therapy theranostics. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/595233fd13ee4b45b34ad988f971721f
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spelling	oai:doaj.org-article:595233fd13ee4b45b34ad988f971721f2021-12-02T06:50:37ZCapping gold nanoparticles with albumin to improve their biomedical properties1178-2013https://doaj.org/article/595233fd13ee4b45b34ad988f971721f2019-08-01T00:00:00Zhttps://www.dovepress.com/capping-gold-nanoparticles-with-albumin-to-improve-their-biomedical-pr-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Karen Bolaños,1–3 Marcelo J Kogan,2,3 Eyleen Araya1,21Departamento de Ciencias Quimicas, Facultad de Ciencias Exactas, Universidad Andres Bello, Santiago, Chile; 2Departamento de Quimica Farmacologica y Toxicologica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile; 3Advanced Center of Chronic Diseases, Santiago, ChileAbstract: Nanotechnology is an emerging field which has created great opportunities either through the creation of new materials or by improving the properties of existing ones. Nanoscale materials with a wide range of applications in areas ranging from engineering to biomedicine have been produced. Gold nanoparticles (AuNPs) have emerged as a therapeutic agent, and are useful for imaging, drug delivery, and photodynamic and photothermal therapy. AuNPs have the advantage of ease of functionalization with therapeutic agents through covalent and ionic binding. Combining AuNPs and other materials can result in nanoplatforms, which can be useful for biomedical applications. Biomaterials such as biomolecules, polymers and proteins can improve the therapeutic properties of nanoparticles, such as their biocompatibility, biodistribution, stability and half-life. Serum albumin is a versatile, non-toxic, stable, and biodegradable protein, in which structural domains and functional groups allow the binding and capping of inorganic nanoparticles. AuNPs coated with albumin have improved properties such as greater compatibility, bioavailability, longer circulation times, lower toxicity, and selective bioaccumulation. In the current article, we review the features of albumin, as well as its interaction with AuNPs, focusing on its biomedical applications.Keywords: albumin, drug delivery, photothermal therapy, theranosticsBolaños KKogan MJAraya EDove Medical PressarticleAlbumindrug deliveryphotothermal therapytheranostics.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 6387-6406 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Albumin drug delivery photothermal therapy theranostics. Medicine (General) R5-920
spellingShingle	Albumin drug delivery photothermal therapy theranostics. Medicine (General) R5-920 Bolaños K Kogan MJ Araya E Capping gold nanoparticles with albumin to improve their biomedical properties
description	Karen Bolaños,1–3 Marcelo J Kogan,2,3 Eyleen Araya1,21Departamento de Ciencias Quimicas, Facultad de Ciencias Exactas, Universidad Andres Bello, Santiago, Chile; 2Departamento de Quimica Farmacologica y Toxicologica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile; 3Advanced Center of Chronic Diseases, Santiago, ChileAbstract: Nanotechnology is an emerging field which has created great opportunities either through the creation of new materials or by improving the properties of existing ones. Nanoscale materials with a wide range of applications in areas ranging from engineering to biomedicine have been produced. Gold nanoparticles (AuNPs) have emerged as a therapeutic agent, and are useful for imaging, drug delivery, and photodynamic and photothermal therapy. AuNPs have the advantage of ease of functionalization with therapeutic agents through covalent and ionic binding. Combining AuNPs and other materials can result in nanoplatforms, which can be useful for biomedical applications. Biomaterials such as biomolecules, polymers and proteins can improve the therapeutic properties of nanoparticles, such as their biocompatibility, biodistribution, stability and half-life. Serum albumin is a versatile, non-toxic, stable, and biodegradable protein, in which structural domains and functional groups allow the binding and capping of inorganic nanoparticles. AuNPs coated with albumin have improved properties such as greater compatibility, bioavailability, longer circulation times, lower toxicity, and selective bioaccumulation. In the current article, we review the features of albumin, as well as its interaction with AuNPs, focusing on its biomedical applications.Keywords: albumin, drug delivery, photothermal therapy, theranostics
format	article
author	Bolaños K Kogan MJ Araya E
author_facet	Bolaños K Kogan MJ Araya E
author_sort	Bolaños K
title	Capping gold nanoparticles with albumin to improve their biomedical properties
title_short	Capping gold nanoparticles with albumin to improve their biomedical properties
title_full	Capping gold nanoparticles with albumin to improve their biomedical properties
title_fullStr	Capping gold nanoparticles with albumin to improve their biomedical properties
title_full_unstemmed	Capping gold nanoparticles with albumin to improve their biomedical properties
title_sort	capping gold nanoparticles with albumin to improve their biomedical properties
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/595233fd13ee4b45b34ad988f971721f
work_keys_str_mv	AT bolanosk cappinggoldnanoparticleswithalbumintoimprovetheirbiomedicalproperties AT koganmj cappinggoldnanoparticleswithalbumintoimprovetheirbiomedicalproperties AT arayae cappinggoldnanoparticleswithalbumintoimprovetheirbiomedicalproperties
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Capping gold nanoparticles with albumin to improve their biomedical properties

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