Label-free functional and structural imaging of liver microvascular complex in mice by Jones matrix optical coherence tomography

Abstract We demonstrate label-free imaging of the functional and structural properties of microvascular complex in mice liver. The imaging was performed by a custom-built Jones-matrix based polarization sensitive optical coherence tomography (JM-OCT), which is capable of measuring tissue’s attenuati...

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Autores principales:	Pradipta Mukherjee, Arata Miyazawa, Shinichi Fukuda, Toshiharu Yamashita, Donny Lukmanto, Kosuke Okada, Ibrahim Abd El-Sadek, Lida Zhu, Shuichi Makita, Tetsuro Oshika, Yoshiaki Yasuno
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/59536500c5cd460cb18d77b925c31069
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spelling	oai:doaj.org-article:59536500c5cd460cb18d77b925c310692021-12-02T18:01:52ZLabel-free functional and structural imaging of liver microvascular complex in mice by Jones matrix optical coherence tomography10.1038/s41598-021-98909-62045-2322https://doaj.org/article/59536500c5cd460cb18d77b925c310692021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98909-6https://doaj.org/toc/2045-2322Abstract We demonstrate label-free imaging of the functional and structural properties of microvascular complex in mice liver. The imaging was performed by a custom-built Jones-matrix based polarization sensitive optical coherence tomography (JM-OCT), which is capable of measuring tissue’s attenuation coefficient, birefringence, and tiny tissue dynamics. Two longitudinal studies comprising a healthy liver and an early fibrotic liver model were performed. In the healthy liver, we observed distinctive high dynamics beneath the vessel at the initial time point (0 h) and reappearance of high dynamics at 32-h time point. In the early fibrotic liver model, we observed high dynamics signal that reveals a clear network vascular structure by volume rendering. Longitudinal time-course imaging showed that these high dynamics signals faded and decreased over time.Pradipta MukherjeeArata MiyazawaShinichi FukudaToshiharu YamashitaDonny LukmantoKosuke OkadaIbrahim Abd El-SadekLida ZhuShuichi MakitaTetsuro OshikaYoshiaki YasunoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pradipta Mukherjee Arata Miyazawa Shinichi Fukuda Toshiharu Yamashita Donny Lukmanto Kosuke Okada Ibrahim Abd El-Sadek Lida Zhu Shuichi Makita Tetsuro Oshika Yoshiaki Yasuno Label-free functional and structural imaging of liver microvascular complex in mice by Jones matrix optical coherence tomography
description	Abstract We demonstrate label-free imaging of the functional and structural properties of microvascular complex in mice liver. The imaging was performed by a custom-built Jones-matrix based polarization sensitive optical coherence tomography (JM-OCT), which is capable of measuring tissue’s attenuation coefficient, birefringence, and tiny tissue dynamics. Two longitudinal studies comprising a healthy liver and an early fibrotic liver model were performed. In the healthy liver, we observed distinctive high dynamics beneath the vessel at the initial time point (0 h) and reappearance of high dynamics at 32-h time point. In the early fibrotic liver model, we observed high dynamics signal that reveals a clear network vascular structure by volume rendering. Longitudinal time-course imaging showed that these high dynamics signals faded and decreased over time.
format	article
author	Pradipta Mukherjee Arata Miyazawa Shinichi Fukuda Toshiharu Yamashita Donny Lukmanto Kosuke Okada Ibrahim Abd El-Sadek Lida Zhu Shuichi Makita Tetsuro Oshika Yoshiaki Yasuno
author_facet	Pradipta Mukherjee Arata Miyazawa Shinichi Fukuda Toshiharu Yamashita Donny Lukmanto Kosuke Okada Ibrahim Abd El-Sadek Lida Zhu Shuichi Makita Tetsuro Oshika Yoshiaki Yasuno
author_sort	Pradipta Mukherjee
title	Label-free functional and structural imaging of liver microvascular complex in mice by Jones matrix optical coherence tomography
title_short	Label-free functional and structural imaging of liver microvascular complex in mice by Jones matrix optical coherence tomography
title_full	Label-free functional and structural imaging of liver microvascular complex in mice by Jones matrix optical coherence tomography
title_fullStr	Label-free functional and structural imaging of liver microvascular complex in mice by Jones matrix optical coherence tomography
title_full_unstemmed	Label-free functional and structural imaging of liver microvascular complex in mice by Jones matrix optical coherence tomography
title_sort	label-free functional and structural imaging of liver microvascular complex in mice by jones matrix optical coherence tomography
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/59536500c5cd460cb18d77b925c31069
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Label-free functional and structural imaging of liver microvascular complex in mice by Jones matrix optical coherence tomography

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