Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice

There are currently no effective therapies available for acute kidney injury (AKI). Here the authors generate molybdenum-based polyoxometalate nanoclusters and show that these have preferential renal uptake and can ameliorate AKI pathology in mice by scavenging reactive oxygen species.

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Autores principales:	Dalong Ni, Dawei Jiang, Christopher J. Kutyreff, Jianhao Lai, Yongjun Yan, Todd E. Barnhart, Bo Yu, Hyung-Jun Im, Lei Kang, Steve Y. Cho, Zhaofei Liu, Peng Huang, Jonathan W. Engle, Weibo Cai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5959a910616a4c1bb0a94672ebd75639
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spelling	oai:doaj.org-article:5959a910616a4c1bb0a94672ebd756392021-12-02T16:50:08ZMolybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice10.1038/s41467-018-07890-82041-1723https://doaj.org/article/5959a910616a4c1bb0a94672ebd756392018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07890-8https://doaj.org/toc/2041-1723There are currently no effective therapies available for acute kidney injury (AKI). Here the authors generate molybdenum-based polyoxometalate nanoclusters and show that these have preferential renal uptake and can ameliorate AKI pathology in mice by scavenging reactive oxygen species.Dalong NiDawei JiangChristopher J. KutyreffJianhao LaiYongjun YanTodd E. BarnhartBo YuHyung-Jun ImLei KangSteve Y. ChoZhaofei LiuPeng HuangJonathan W. EngleWeibo CaiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dalong Ni Dawei Jiang Christopher J. Kutyreff Jianhao Lai Yongjun Yan Todd E. Barnhart Bo Yu Hyung-Jun Im Lei Kang Steve Y. Cho Zhaofei Liu Peng Huang Jonathan W. Engle Weibo Cai Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice
description	There are currently no effective therapies available for acute kidney injury (AKI). Here the authors generate molybdenum-based polyoxometalate nanoclusters and show that these have preferential renal uptake and can ameliorate AKI pathology in mice by scavenging reactive oxygen species.
format	article
author	Dalong Ni Dawei Jiang Christopher J. Kutyreff Jianhao Lai Yongjun Yan Todd E. Barnhart Bo Yu Hyung-Jun Im Lei Kang Steve Y. Cho Zhaofei Liu Peng Huang Jonathan W. Engle Weibo Cai
author_facet	Dalong Ni Dawei Jiang Christopher J. Kutyreff Jianhao Lai Yongjun Yan Todd E. Barnhart Bo Yu Hyung-Jun Im Lei Kang Steve Y. Cho Zhaofei Liu Peng Huang Jonathan W. Engle Weibo Cai
author_sort	Dalong Ni
title	Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice
title_short	Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice
title_full	Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice
title_fullStr	Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice
title_full_unstemmed	Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice
title_sort	molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5959a910616a4c1bb0a94672ebd75639
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Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice

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