Cross-sectional and longitudinal assessments of risk factors associated with hypertension and moderately increased albuminuria comorbidity in patients with type 2 diabetes: a 9-year open cohort study

Moluk Hadi Alijanvand,1–3 Ashraf Aminorroaya,2 Iraj Kazemi,4 Sima Aminorroaya Yamini,5 Mohsen Janghorbani,1,2 Masoud Amini,2 Marjan Mansourian1,21Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran; 2Isfahan Endocrine and Me...

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Autores principales:	Hadi Alijanvand M, Aminorroaya A, Kazemi I, Aminorroaya Yamini S, Janghorbani M, Amini M, Mansourian M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	hypertension moderately increased albuminuria microalbuminuria type 2 diabetes comorbidity risk factor.‎ Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/595c72a969a646ba9425c68995f4964b
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spelling	oai:doaj.org-article:595c72a969a646ba9425c68995f4964b2021-12-02T07:02:39ZCross-sectional and longitudinal assessments of risk factors associated with hypertension and moderately increased albuminuria comorbidity in patients with type 2 diabetes: a 9-year open cohort study1178-7007https://doaj.org/article/595c72a969a646ba9425c68995f4964b2019-07-01T00:00:00Zhttps://www.dovepress.com/cross-sectional-and-longitudinal-assessments-of-risk-factors-associate-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Moluk Hadi Alijanvand,1–3 Ashraf Aminorroaya,2 Iraj Kazemi,4 Sima Aminorroaya Yamini,5 Mohsen Janghorbani,1,2 Masoud Amini,2 Marjan Mansourian1,21Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran; 2Isfahan Endocrine and Metabolism Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran; 3Student Research Center, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran; 4Department of Statistics, College of Science, University of Isfahan, Isfahan, Iran; 5Department of Engineering and Mathematics, Sheffiled Hallam University, Sheffield, UKBackground: Moderately increased albuminuria (MIA) is strongly associated with hypertension (HTN) in patients with type 2 diabetic mellitus (T2DM). However, the association between risk factors and coexisting HTN and MIA remains unassessed.Objectives: This study aimed to determine both cross-sectional and longitudinal associations of risk factors with HTN and MIA comorbidity in patients with T2DM.Methods: A total of 1,600 patients with T2DM were examined at baseline and longitudinal data were obtained from 1,337 T2DM patients with at least 2 follow-up visits to assess the presence of HTN alone (yes/no), MIA alone (yes/no) and the coexistence of both (yes/no) in a 9-year open cohort study between 2004 and 2013. Bivariate mixed-effects logistic regression with a Bayesian approach was employed to evaluate associations of risk factors with HTN and MIA&lrm; comorbidity in the longitudinal assessment.Results: After adjustment for age and BMI, patients with uncontrolled plasma glucose, as a combined index of the glucose profile, were more likely to have HTN [odds ratio (OR): 1.73 with 95% Bayesian credible intervals (BCI) 1.29–2.20] and MIA [OR: 1.34 (&lrm;95% BCI 1.13–1.62)]. The risks of having HTN and MIA were increased by a one-year raise in diabetes duration [with 0.89 (95% BCI 0.84–0.96) and 0.81 (95% BCI 0.73–0.92) ORs, respectively] and a one-unit increase in non-high-density lipoprotein-cholesterol (Non-HDL-C) [with 1.30 (95% BCI 1.23–1.34) and 1.24 (95% BCI 1.14–1.33) ORs, respectively].Conclusions: T2DM patients with HTN,&lrm; MIA, and the coexistence of both had uncontrolled plasma glucose, significantly higher Non-HDL-C, and shorter diabetes duration than the other T2DM patients. Duration of diabetes and uncontrolled plasma glucose index showed the stronger effects on HTN and MIA comorbidity than on each condition separately.Keywords: hypertension, moderately increased albuminuria, microalbuminuria, type 2 diabetes, comorbidity, risk factorHadi Alijanvand MAminorroaya AKazemi IAminorroaya Yamini SJanghorbani MAmini MMansourian MDove Medical Pressarticlehypertensionmoderately increased albuminuriamicroalbuminuriatype 2 diabetescomorbidityrisk factor.‎Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 1123-1139 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	hypertension moderately increased albuminuria microalbuminuria type 2 diabetes comorbidity risk factor.‎ Specialties of internal medicine RC581-951
spellingShingle	hypertension moderately increased albuminuria microalbuminuria type 2 diabetes comorbidity risk factor.‎ Specialties of internal medicine RC581-951 Hadi Alijanvand M Aminorroaya A Kazemi I Aminorroaya Yamini S Janghorbani M Amini M Mansourian M Cross-sectional and longitudinal assessments of risk factors associated with hypertension and moderately increased albuminuria comorbidity in patients with type 2 diabetes: a 9-year open cohort study
description	Moluk Hadi Alijanvand,1–3 Ashraf Aminorroaya,2 Iraj Kazemi,4 Sima Aminorroaya Yamini,5 Mohsen Janghorbani,1,2 Masoud Amini,2 Marjan Mansourian1,21Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran; 2Isfahan Endocrine and Metabolism Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran; 3Student Research Center, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran; 4Department of Statistics, College of Science, University of Isfahan, Isfahan, Iran; 5Department of Engineering and Mathematics, Sheffiled Hallam University, Sheffield, UKBackground: Moderately increased albuminuria (MIA) is strongly associated with hypertension (HTN) in patients with type 2 diabetic mellitus (T2DM). However, the association between risk factors and coexisting HTN and MIA remains unassessed.Objectives: This study aimed to determine both cross-sectional and longitudinal associations of risk factors with HTN and MIA comorbidity in patients with T2DM.Methods: A total of 1,600 patients with T2DM were examined at baseline and longitudinal data were obtained from 1,337 T2DM patients with at least 2 follow-up visits to assess the presence of HTN alone (yes/no), MIA alone (yes/no) and the coexistence of both (yes/no) in a 9-year open cohort study between 2004 and 2013. Bivariate mixed-effects logistic regression with a Bayesian approach was employed to evaluate associations of risk factors with HTN and MIA&lrm; comorbidity in the longitudinal assessment.Results: After adjustment for age and BMI, patients with uncontrolled plasma glucose, as a combined index of the glucose profile, were more likely to have HTN [odds ratio (OR): 1.73 with 95% Bayesian credible intervals (BCI) 1.29–2.20] and MIA [OR: 1.34 (&lrm;95% BCI 1.13–1.62)]. The risks of having HTN and MIA were increased by a one-year raise in diabetes duration [with 0.89 (95% BCI 0.84–0.96) and 0.81 (95% BCI 0.73–0.92) ORs, respectively] and a one-unit increase in non-high-density lipoprotein-cholesterol (Non-HDL-C) [with 1.30 (95% BCI 1.23–1.34) and 1.24 (95% BCI 1.14–1.33) ORs, respectively].Conclusions: T2DM patients with HTN,&lrm; MIA, and the coexistence of both had uncontrolled plasma glucose, significantly higher Non-HDL-C, and shorter diabetes duration than the other T2DM patients. Duration of diabetes and uncontrolled plasma glucose index showed the stronger effects on HTN and MIA comorbidity than on each condition separately.Keywords: hypertension, moderately increased albuminuria, microalbuminuria, type 2 diabetes, comorbidity, risk factor
format	article
author	Hadi Alijanvand M Aminorroaya A Kazemi I Aminorroaya Yamini S Janghorbani M Amini M Mansourian M
author_facet	Hadi Alijanvand M Aminorroaya A Kazemi I Aminorroaya Yamini S Janghorbani M Amini M Mansourian M
author_sort	Hadi Alijanvand M
title	Cross-sectional and longitudinal assessments of risk factors associated with hypertension and moderately increased albuminuria comorbidity in patients with type 2 diabetes: a 9-year open cohort study
title_short	Cross-sectional and longitudinal assessments of risk factors associated with hypertension and moderately increased albuminuria comorbidity in patients with type 2 diabetes: a 9-year open cohort study
title_full	Cross-sectional and longitudinal assessments of risk factors associated with hypertension and moderately increased albuminuria comorbidity in patients with type 2 diabetes: a 9-year open cohort study
title_fullStr	Cross-sectional and longitudinal assessments of risk factors associated with hypertension and moderately increased albuminuria comorbidity in patients with type 2 diabetes: a 9-year open cohort study
title_full_unstemmed	Cross-sectional and longitudinal assessments of risk factors associated with hypertension and moderately increased albuminuria comorbidity in patients with type 2 diabetes: a 9-year open cohort study
title_sort	cross-sectional and longitudinal assessments of risk factors associated with hypertension and moderately increased albuminuria comorbidity in patients with type 2 diabetes: a 9-year open cohort study
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/595c72a969a646ba9425c68995f4964b
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Cross-sectional and longitudinal assessments of risk factors associated with hypertension and moderately increased albuminuria comorbidity in patients with type 2 diabetes: a 9-year open cohort study

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