SARI inhibits angiogenesis and tumour growth of human colon cancer through directly targeting ceruloplasmin

Ceruloplasmin has an important role in the stabilization and nuclear transport of HIF-1α, thus regulating VEGF expression. Here the authors show that the transcription factor SARI reduces colorectal cancer growth and angiogenesis in vivoby inducing the degradation of ceruloplasmin, thereby inhibitin...

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Autores principales:	Lei Dai, Xueliang Cui, Xin Zhang, Lin Cheng, Yi Liu, Yang Yang, Ping Fan, Qingnan Wang, Yi Lin, Junfeng Zhang, Chunlei Li, Ying Mao, Qin Wang, Xiaolan Su, Shuang Zhang, Yong Peng, Hanshuo Yang, Xun Hu, Jinliang Yang, Meijuan Huang, Rong Xiang, Dechao Yu, Zongguang Zhou, Yuquan Wei, Hongxin Deng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/595cedc1483c43abac9828544ee7603a
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spelling	oai:doaj.org-article:595cedc1483c43abac9828544ee7603a2021-12-02T17:31:18ZSARI inhibits angiogenesis and tumour growth of human colon cancer through directly targeting ceruloplasmin10.1038/ncomms119962041-1723https://doaj.org/article/595cedc1483c43abac9828544ee7603a2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11996https://doaj.org/toc/2041-1723Ceruloplasmin has an important role in the stabilization and nuclear transport of HIF-1α, thus regulating VEGF expression. Here the authors show that the transcription factor SARI reduces colorectal cancer growth and angiogenesis in vivoby inducing the degradation of ceruloplasmin, thereby inhibiting the HIFα/VEGF axis.Lei DaiXueliang CuiXin ZhangLin ChengYi LiuYang YangPing FanQingnan WangYi LinJunfeng ZhangChunlei LiYing MaoQin WangXiaolan SuShuang ZhangYong PengHanshuo YangXun HuJinliang YangMeijuan HuangRong XiangDechao YuZongguang ZhouYuquan WeiHongxin DengNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lei Dai Xueliang Cui Xin Zhang Lin Cheng Yi Liu Yang Yang Ping Fan Qingnan Wang Yi Lin Junfeng Zhang Chunlei Li Ying Mao Qin Wang Xiaolan Su Shuang Zhang Yong Peng Hanshuo Yang Xun Hu Jinliang Yang Meijuan Huang Rong Xiang Dechao Yu Zongguang Zhou Yuquan Wei Hongxin Deng SARI inhibits angiogenesis and tumour growth of human colon cancer through directly targeting ceruloplasmin
description	Ceruloplasmin has an important role in the stabilization and nuclear transport of HIF-1α, thus regulating VEGF expression. Here the authors show that the transcription factor SARI reduces colorectal cancer growth and angiogenesis in vivoby inducing the degradation of ceruloplasmin, thereby inhibiting the HIFα/VEGF axis.
format	article
author	Lei Dai Xueliang Cui Xin Zhang Lin Cheng Yi Liu Yang Yang Ping Fan Qingnan Wang Yi Lin Junfeng Zhang Chunlei Li Ying Mao Qin Wang Xiaolan Su Shuang Zhang Yong Peng Hanshuo Yang Xun Hu Jinliang Yang Meijuan Huang Rong Xiang Dechao Yu Zongguang Zhou Yuquan Wei Hongxin Deng
author_facet	Lei Dai Xueliang Cui Xin Zhang Lin Cheng Yi Liu Yang Yang Ping Fan Qingnan Wang Yi Lin Junfeng Zhang Chunlei Li Ying Mao Qin Wang Xiaolan Su Shuang Zhang Yong Peng Hanshuo Yang Xun Hu Jinliang Yang Meijuan Huang Rong Xiang Dechao Yu Zongguang Zhou Yuquan Wei Hongxin Deng
author_sort	Lei Dai
title	SARI inhibits angiogenesis and tumour growth of human colon cancer through directly targeting ceruloplasmin
title_short	SARI inhibits angiogenesis and tumour growth of human colon cancer through directly targeting ceruloplasmin
title_full	SARI inhibits angiogenesis and tumour growth of human colon cancer through directly targeting ceruloplasmin
title_fullStr	SARI inhibits angiogenesis and tumour growth of human colon cancer through directly targeting ceruloplasmin
title_full_unstemmed	SARI inhibits angiogenesis and tumour growth of human colon cancer through directly targeting ceruloplasmin
title_sort	sari inhibits angiogenesis and tumour growth of human colon cancer through directly targeting ceruloplasmin
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/595cedc1483c43abac9828544ee7603a
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SARI inhibits angiogenesis and tumour growth of human colon cancer through directly targeting ceruloplasmin

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