SARI inhibits angiogenesis and tumour growth of human colon cancer through directly targeting ceruloplasmin

SARI inhibits angiogenesis and tumour growth of human colon cancer through directly targeting ceruloplasmin

Ceruloplasmin has an important role in the stabilization and nuclear transport of HIF-1α, thus regulating VEGF expression. Here the authors show that the transcription factor SARI reduces colorectal cancer growth and angiogenesis in vivoby inducing the degradation of ceruloplasmin, thereby inhibitin...

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Autores principales: Lei Dai, Xueliang Cui, Xin Zhang, Lin Cheng, Yi Liu, Yang Yang, Ping Fan, Qingnan Wang, Yi Lin, Junfeng Zhang, Chunlei Li, Ying Mao, Qin Wang, Xiaolan Su, Shuang Zhang, Yong Peng, Hanshuo Yang, Xun Hu, Jinliang Yang, Meijuan Huang, Rong Xiang, Dechao Yu, Zongguang Zhou, Yuquan Wei, Hongxin Deng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/595cedc1483c43abac9828544ee7603a
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