Prevalence and Risk Factors of SARS-CoV-2 Infection among Parturients and Newborns from Luanda, Angola

SARS-CoV-2 emerged in China in December 2019, creating a massive public health concern. Although previous studies have identified SARS-CoV-2 in pregnant women, the possibility of transmission to newborns remains uncertain. Herein, we investigated SARS-CoV-2 infection and risk factors among parturien...

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Autores principales:	Cruz S. Sebastião, Paolo Parimbelli, Manuela Mendes, Euclides Sacomboio, Joana Morais, Jocelyne Neto de Vasconcelos, Miguel Brito
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	SARS-CoV-2 COVID-19 pregnant women maternal breastfeeding newborn screening Luanda Medicine R
Acceso en línea:	https://doaj.org/article/595d0ad97f8242068d2f7cc8b66aa023
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spelling	oai:doaj.org-article:595d0ad97f8242068d2f7cc8b66aa0232021-11-25T18:38:42ZPrevalence and Risk Factors of SARS-CoV-2 Infection among Parturients and Newborns from Luanda, Angola10.3390/pathogens101114942076-0817https://doaj.org/article/595d0ad97f8242068d2f7cc8b66aa0232021-11-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1494https://doaj.org/toc/2076-0817SARS-CoV-2 emerged in China in December 2019, creating a massive public health concern. Although previous studies have identified SARS-CoV-2 in pregnant women, the possibility of transmission to newborns remains uncertain. Herein, we investigated SARS-CoV-2 infection and risk factors among parturients and newborns. This was a cross-sectional study carried out with 3633 parturients from Luanda, Angola, between January and April 2021, with an age ranging from 13 to 48 years. SARS-CoV-2 infection of the parturients was further confirmed with RT-PCR after COVID-19 Ag Rapid Testing. About 0.4% of parturients tested positive on the day of delivery. Surprisingly, parturients from urbanized areas (OR: 0.18, <i>p</i> = 0.025) had a low chance of infection. None of the newborns tested positive in the first 24 h after birth, while one (9.1%, 1/10) of the newborns tested positive with pharyngeal swabs seven days after birth. However, whether the case was due to vertical transmission from mother to child remains to be confirmed. The mother’s residence, education level, antenatal follow-up, and delivery category were related to SARS-CoV-2 transmission (<i>p</i> < 0.05). Our findings showed a relatively low SARS-CoV-2 infection from parturients to newborns, regardless of the severity of the maternal disease. Furthermore, these findings are an early assessment of COVID-19 cases in late pregnancy, which could indicate the need for intensive management of SARS-CoV-2 infection among parturients in Angola. Further studies are needed on the consequences of SARS-CoV-2 among pregnant women and neonates from Angola.Cruz S. SebastiãoPaolo ParimbelliManuela MendesEuclides SacomboioJoana MoraisJocelyne Neto de VasconcelosMiguel BritoMDPI AGarticleSARS-CoV-2COVID-19pregnant womenmaternal breastfeedingnewborn screeningLuandaMedicineRENPathogens, Vol 10, Iss 1494, p 1494 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 COVID-19 pregnant women maternal breastfeeding newborn screening Luanda Medicine R
spellingShingle	SARS-CoV-2 COVID-19 pregnant women maternal breastfeeding newborn screening Luanda Medicine R Cruz S. Sebastião Paolo Parimbelli Manuela Mendes Euclides Sacomboio Joana Morais Jocelyne Neto de Vasconcelos Miguel Brito Prevalence and Risk Factors of SARS-CoV-2 Infection among Parturients and Newborns from Luanda, Angola
description	SARS-CoV-2 emerged in China in December 2019, creating a massive public health concern. Although previous studies have identified SARS-CoV-2 in pregnant women, the possibility of transmission to newborns remains uncertain. Herein, we investigated SARS-CoV-2 infection and risk factors among parturients and newborns. This was a cross-sectional study carried out with 3633 parturients from Luanda, Angola, between January and April 2021, with an age ranging from 13 to 48 years. SARS-CoV-2 infection of the parturients was further confirmed with RT-PCR after COVID-19 Ag Rapid Testing. About 0.4% of parturients tested positive on the day of delivery. Surprisingly, parturients from urbanized areas (OR: 0.18, <i>p</i> = 0.025) had a low chance of infection. None of the newborns tested positive in the first 24 h after birth, while one (9.1%, 1/10) of the newborns tested positive with pharyngeal swabs seven days after birth. However, whether the case was due to vertical transmission from mother to child remains to be confirmed. The mother’s residence, education level, antenatal follow-up, and delivery category were related to SARS-CoV-2 transmission (<i>p</i> < 0.05). Our findings showed a relatively low SARS-CoV-2 infection from parturients to newborns, regardless of the severity of the maternal disease. Furthermore, these findings are an early assessment of COVID-19 cases in late pregnancy, which could indicate the need for intensive management of SARS-CoV-2 infection among parturients in Angola. Further studies are needed on the consequences of SARS-CoV-2 among pregnant women and neonates from Angola.
format	article
author	Cruz S. Sebastião Paolo Parimbelli Manuela Mendes Euclides Sacomboio Joana Morais Jocelyne Neto de Vasconcelos Miguel Brito
author_facet	Cruz S. Sebastião Paolo Parimbelli Manuela Mendes Euclides Sacomboio Joana Morais Jocelyne Neto de Vasconcelos Miguel Brito
author_sort	Cruz S. Sebastião
title	Prevalence and Risk Factors of SARS-CoV-2 Infection among Parturients and Newborns from Luanda, Angola
title_short	Prevalence and Risk Factors of SARS-CoV-2 Infection among Parturients and Newborns from Luanda, Angola
title_full	Prevalence and Risk Factors of SARS-CoV-2 Infection among Parturients and Newborns from Luanda, Angola
title_fullStr	Prevalence and Risk Factors of SARS-CoV-2 Infection among Parturients and Newborns from Luanda, Angola
title_full_unstemmed	Prevalence and Risk Factors of SARS-CoV-2 Infection among Parturients and Newborns from Luanda, Angola
title_sort	prevalence and risk factors of sars-cov-2 infection among parturients and newborns from luanda, angola
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/595d0ad97f8242068d2f7cc8b66aa023
work_keys_str_mv	AT cruzssebastiao prevalenceandriskfactorsofsarscov2infectionamongparturientsandnewbornsfromluandaangola AT paoloparimbelli prevalenceandriskfactorsofsarscov2infectionamongparturientsandnewbornsfromluandaangola AT manuelamendes prevalenceandriskfactorsofsarscov2infectionamongparturientsandnewbornsfromluandaangola AT euclidessacomboio prevalenceandriskfactorsofsarscov2infectionamongparturientsandnewbornsfromluandaangola AT joanamorais prevalenceandriskfactorsofsarscov2infectionamongparturientsandnewbornsfromluandaangola AT jocelynenetodevasconcelos prevalenceandriskfactorsofsarscov2infectionamongparturientsandnewbornsfromluandaangola AT miguelbrito prevalenceandriskfactorsofsarscov2infectionamongparturientsandnewbornsfromluandaangola
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Prevalence and Risk Factors of SARS-CoV-2 Infection among Parturients and Newborns from Luanda, Angola

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