Morphological parameters and anatomical locations associated with rupture status of small intracranial aneurysms

Abstract Characterization of the rupture risk factors for small intracranial aneurysms (SIAs, ≤5 mm) is clinically valuable. The present study aims to identify image-based morphological parameters and anatomical locations associated with the rupture status of SIAs. Two hundred and sixty-three patien...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhihui Duan, Yuanhui Li, Sheng Guan, Congmin Ma, Yuezhen Han, Xiangyang Ren, Liping Wei, Wenbo Li, Jiyu Lou, Zhiyuan Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/596013b043714ff89146a5ff0f717d47
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:596013b043714ff89146a5ff0f717d47
record_format	dspace
spelling	oai:doaj.org-article:596013b043714ff89146a5ff0f717d472021-12-02T15:08:30ZMorphological parameters and anatomical locations associated with rupture status of small intracranial aneurysms10.1038/s41598-018-24732-12045-2322https://doaj.org/article/596013b043714ff89146a5ff0f717d472018-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-24732-1https://doaj.org/toc/2045-2322Abstract Characterization of the rupture risk factors for small intracranial aneurysms (SIAs, ≤5 mm) is clinically valuable. The present study aims to identify image-based morphological parameters and anatomical locations associated with the rupture status of SIAs. Two hundred and sixty-three patients with single SIAs (128 ruptured, 135 unruptured) were included, and six morphological parameters, including size, aspect ratio (AR), size ratio (SR), height–width ratio (H/W), flow angle (FA) and aneurysm width–parent artery diameter ratio, and the aneurysm locations were evaluated using three-dimensional geometry, and were used to identify a correlation with aneurysm rupture. Statistically significant differences were observed between ruptured and unruptured groups for AR, SR, H/W, FA, and aneurysm locations, from univariate analyses. Logistic regression analysis further revealed that AR (p = 0.034), SR (p = 0.004), H/W (p = 0.003), and FA (p < 0.001) had the strongest independent correlation with ruptured SIAs after adjustment for age, gender and other clinical risk factors. A future study on a larger SIA cohort need to establish to what extent the AR, SR, H/W and FA increase the risk of rupture in patients with unruptured SIAs in terms of absolute risks.Zhihui DuanYuanhui LiSheng GuanCongmin MaYuezhen HanXiangyang RenLiping WeiWenbo LiJiyu LouZhiyuan YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhihui Duan Yuanhui Li Sheng Guan Congmin Ma Yuezhen Han Xiangyang Ren Liping Wei Wenbo Li Jiyu Lou Zhiyuan Yang Morphological parameters and anatomical locations associated with rupture status of small intracranial aneurysms
description	Abstract Characterization of the rupture risk factors for small intracranial aneurysms (SIAs, ≤5 mm) is clinically valuable. The present study aims to identify image-based morphological parameters and anatomical locations associated with the rupture status of SIAs. Two hundred and sixty-three patients with single SIAs (128 ruptured, 135 unruptured) were included, and six morphological parameters, including size, aspect ratio (AR), size ratio (SR), height–width ratio (H/W), flow angle (FA) and aneurysm width–parent artery diameter ratio, and the aneurysm locations were evaluated using three-dimensional geometry, and were used to identify a correlation with aneurysm rupture. Statistically significant differences were observed between ruptured and unruptured groups for AR, SR, H/W, FA, and aneurysm locations, from univariate analyses. Logistic regression analysis further revealed that AR (p = 0.034), SR (p = 0.004), H/W (p = 0.003), and FA (p < 0.001) had the strongest independent correlation with ruptured SIAs after adjustment for age, gender and other clinical risk factors. A future study on a larger SIA cohort need to establish to what extent the AR, SR, H/W and FA increase the risk of rupture in patients with unruptured SIAs in terms of absolute risks.
format	article
author	Zhihui Duan Yuanhui Li Sheng Guan Congmin Ma Yuezhen Han Xiangyang Ren Liping Wei Wenbo Li Jiyu Lou Zhiyuan Yang
author_facet	Zhihui Duan Yuanhui Li Sheng Guan Congmin Ma Yuezhen Han Xiangyang Ren Liping Wei Wenbo Li Jiyu Lou Zhiyuan Yang
author_sort	Zhihui Duan
title	Morphological parameters and anatomical locations associated with rupture status of small intracranial aneurysms
title_short	Morphological parameters and anatomical locations associated with rupture status of small intracranial aneurysms
title_full	Morphological parameters and anatomical locations associated with rupture status of small intracranial aneurysms
title_fullStr	Morphological parameters and anatomical locations associated with rupture status of small intracranial aneurysms
title_full_unstemmed	Morphological parameters and anatomical locations associated with rupture status of small intracranial aneurysms
title_sort	morphological parameters and anatomical locations associated with rupture status of small intracranial aneurysms
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/596013b043714ff89146a5ff0f717d47
work_keys_str_mv	AT zhihuiduan morphologicalparametersandanatomicallocationsassociatedwithrupturestatusofsmallintracranialaneurysms AT yuanhuili morphologicalparametersandanatomicallocationsassociatedwithrupturestatusofsmallintracranialaneurysms AT shengguan morphologicalparametersandanatomicallocationsassociatedwithrupturestatusofsmallintracranialaneurysms AT congminma morphologicalparametersandanatomicallocationsassociatedwithrupturestatusofsmallintracranialaneurysms AT yuezhenhan morphologicalparametersandanatomicallocationsassociatedwithrupturestatusofsmallintracranialaneurysms AT xiangyangren morphologicalparametersandanatomicallocationsassociatedwithrupturestatusofsmallintracranialaneurysms AT lipingwei morphologicalparametersandanatomicallocationsassociatedwithrupturestatusofsmallintracranialaneurysms AT wenboli morphologicalparametersandanatomicallocationsassociatedwithrupturestatusofsmallintracranialaneurysms AT jiyulou morphologicalparametersandanatomicallocationsassociatedwithrupturestatusofsmallintracranialaneurysms AT zhiyuanyang morphologicalparametersandanatomicallocationsassociatedwithrupturestatusofsmallintracranialaneurysms
_version_	1718388122513833984

Morphological parameters and anatomical locations associated with rupture status of small intracranial aneurysms

Ejemplares similares