How Can Vaccines Contribute to Solving the Antimicrobial Resistance Problem?

ABSTRACT There is a growing appreciation for the role of vaccines in confronting the problem of antimicrobial resistance (AMR). Vaccines can reduce the prevalence of resistance by reducing the need for antimicrobial use and can reduce its impact by reducing the total number of cases. By reducing the...

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Autores principales:	Marc Lipsitch, George R. Siber
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/596aee8b5d8b464dbf618ec8bb5c1c6a
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spelling	oai:doaj.org-article:596aee8b5d8b464dbf618ec8bb5c1c6a2021-11-15T15:50:17ZHow Can Vaccines Contribute to Solving the Antimicrobial Resistance Problem?10.1128/mBio.00428-162150-7511https://doaj.org/article/596aee8b5d8b464dbf618ec8bb5c1c6a2016-07-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00428-16https://doaj.org/toc/2150-7511ABSTRACT There is a growing appreciation for the role of vaccines in confronting the problem of antimicrobial resistance (AMR). Vaccines can reduce the prevalence of resistance by reducing the need for antimicrobial use and can reduce its impact by reducing the total number of cases. By reducing the number of pathogens that may be responsible for a particular clinical syndrome, vaccines can permit the use of narrower-spectrum antibiotics for empirical therapy. These effects may be amplified by herd immunity, extending protection to unvaccinated persons in the population. Because much selection for resistance is due to selection on bystander members of the normal flora, vaccination can reduce pressure for resistance even in pathogens not included in the vaccine. Some vaccines have had disproportionate effects on drug-resistant lineages within the target species, a benefit that could be more deliberately exploited in vaccine design. We describe the effects of current vaccines in controlling AMR, survey some vaccines in development with the potential to do so further, and discuss strategies to amplify these benefits. We conclude with a discussion of research and policy priorities to more fully enlist vaccines in the battle against AMR.Marc LipsitchGeorge R. SiberAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 3 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Marc Lipsitch George R. Siber How Can Vaccines Contribute to Solving the Antimicrobial Resistance Problem?
description	ABSTRACT There is a growing appreciation for the role of vaccines in confronting the problem of antimicrobial resistance (AMR). Vaccines can reduce the prevalence of resistance by reducing the need for antimicrobial use and can reduce its impact by reducing the total number of cases. By reducing the number of pathogens that may be responsible for a particular clinical syndrome, vaccines can permit the use of narrower-spectrum antibiotics for empirical therapy. These effects may be amplified by herd immunity, extending protection to unvaccinated persons in the population. Because much selection for resistance is due to selection on bystander members of the normal flora, vaccination can reduce pressure for resistance even in pathogens not included in the vaccine. Some vaccines have had disproportionate effects on drug-resistant lineages within the target species, a benefit that could be more deliberately exploited in vaccine design. We describe the effects of current vaccines in controlling AMR, survey some vaccines in development with the potential to do so further, and discuss strategies to amplify these benefits. We conclude with a discussion of research and policy priorities to more fully enlist vaccines in the battle against AMR.
format	article
author	Marc Lipsitch George R. Siber
author_facet	Marc Lipsitch George R. Siber
author_sort	Marc Lipsitch
title	How Can Vaccines Contribute to Solving the Antimicrobial Resistance Problem?
title_short	How Can Vaccines Contribute to Solving the Antimicrobial Resistance Problem?
title_full	How Can Vaccines Contribute to Solving the Antimicrobial Resistance Problem?
title_fullStr	How Can Vaccines Contribute to Solving the Antimicrobial Resistance Problem?
title_full_unstemmed	How Can Vaccines Contribute to Solving the Antimicrobial Resistance Problem?
title_sort	how can vaccines contribute to solving the antimicrobial resistance problem?
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/596aee8b5d8b464dbf618ec8bb5c1c6a
work_keys_str_mv	AT marclipsitch howcanvaccinescontributetosolvingtheantimicrobialresistanceproblem AT georgersiber howcanvaccinescontributetosolvingtheantimicrobialresistanceproblem
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How Can Vaccines Contribute to Solving the Antimicrobial Resistance Problem?

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